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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 121–132 of 373 articles

PLOS

Climate-sensitive patterns of premature cardiovascular mortality in a subtropical city

This study aimed to investigate climate-sensitive temporal patterns associated with premature mortality due to cardiovascular diseases (CVD), ischemic heart disease (IHD), and acute myocardial infarction (AMI) in a large subtropical city in southern Brazil. Daily premature mortality records (ages 30–69) from 2010 to 2019 were analyzed together with meteorological data, including temperature, humidity, atmospheric pressure, precipitation, wind, and solar radiation, as well as temporally aggregate...

Cardiovascular
Noélia de Moraes Aguirre Carnasciali, Fábio Teodoro de Souza, Demian da Silveira Barcellos•
PLOS

Association of airway CCL28 with type 2 inflammation and secretory IgA in patients with asthma

Objective: This study aimed to investigate sputum CCL28 expression in patients with acute asthma exacerbations and its association with type 2 airway inflammation and secretory IgA. We further evaluated whether sputum CCL28, alone or in combination with routine clinical indicators, could assist in identifying eosinophilic asthma. Methods: This study included 75 patients with non-severe acute asthma and 27 healthy controls. Induced sputum samples were collected, and the levels of CCL28, IL-4, IL-...

Asthma
Xiaohan Jiang, Jinmei Zhang, Ke Xu, Xiaobing Yang, Yuanfei Yan, Hao Chai, Jiyong Ma, Ying Shi•
PLOS

Alzheimer’s disease research must connect vascular molecular phenotypes with physiology

Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. Longitudinal studies are needed to link molecular and structural changes to vascular mechanics, hemodynamics, and tissue perfusion. Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. This Perspective argues for longitudinal studies to link molecular and structural changes to vasc...

Alzheimer’S Disease
Thomas S. Lewis, Jessica Wagner, Jonas J. Neher•
PLOS

Factors associated with the optimal uptake of intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine: The experiences of postpartum women attending child welfare clinics in three rural districts in the Western Region of Ghana

Background: Intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) is a key preventive strategy. However, optimal uptake remains inconsistent despite high antenatal care (ANC) attendance. This study assessed factors associated with optimal IPTp-SP uptake and explored the experiences of postpartum women in rural Ghana. Methods: A convergent parallel mixed-method study was conducted among 1,155 postpartum women attending child welfare clinics in Jomoro, Prestea-Hun...

Pregnancy
Gifty Amugi, Daniel Tetteh Agudey, Nana Mireku Gyimah, Pius Mensah, Isaac Kwarkye, Gabriel Yelkoang Gozie Yengliereh, Kofi Jean Claude, Bryony Brookman-Eshun, Sylvester Chinbuah•
PLOS

Oxidative stress-driven cellular heterogeneity in Knee Osteoarthritis: scRNA-seq pinpoints SPP1 and CYBA for diagnostic development

Knee osteoarthritis (KOA) is a progressive degenerative joint disease characterized by cartilage degeneration, synovial inflammation, and subchondral bone remodeling. Oxidative stress plays a critical role in KOA pathogenesis. This study aimed to identify oxidative stress–related hub genes by integrating single-cell RNA sequencing (scRNA-seq) with machine learning to uncover potential diagnostic and prognostic biomarkers for KOA. ScRNA-seq data from KOA cartilage tissues were obtained from the G...

Osteoarthritis
Yijiang Liu, Yiman Chi, Jiefeng Yin, Jun Yao•
PLOS

Beyond mid-thigh: Ultrasound assessment of hamstring muscle architecture at multiple muscle lengths in relation to strength

Objectives: To investigate the relationship between ultrasound-based muscle architecture parameters and isometric knee flexor muscle strength in healthy individuals, and to evaluate whether distal (25%) and proximal (75%) measurement sites differ in their ability to reflect muscle strength compare to the commonly used mid-thigh (50%) region. Methods: Isometric muscle strength was measured in 20 healthy (22.15 ± 2.41 y; 8 females, 12 males) participants using a hand-held dynamometer. Ultrasound p...

Ultrasound
Gulsah Karaca Yilmaz, Ali Cihan Dagli, Omer Batin Gozubuyuk, Nazif Ekin Akalan, Sergen Devran, Meryem Merve Oren Celik, Bulent Bayraktar•
PLOS

Heart rate and blood pressure variability, and baroreflex sensitivity, during heat exposure in persons with type 2 diabetes and hypertension

The autonomic nervous system regulates cardiovascular homeostasis during stressors such as heat, but the effects of type 2 diabetes (T2D) with hypertension on such responses are unclear. Twenty male participants (10 with type 2 diabetes and hypertension and 10 age-matched healthy controls; mean ages 64 ± 4.14 and 63 ± 5.42 years) underwent a 90-minute whole-body heat exposure at 40 °C and 50% relative humidity. Heart rate variability (HRV), baroreflex sensitivity (BRS), and blood pressure variab...

Blood Pressure
Mojdeh Rafieian, Erlend Hoftun Farbu, Anje Christina Höper, Rasmus Valtonen, Mika Kallio, Henna Hyrkäs-Palmu, Craig Crandall, Tiina Maria Ikäheimo•
PLOS

Stroke knowledge and intended care-seeking behavior among adults with hypertension and type 2 diabetes: A cross-sectional study

Background: Stroke health literacy refers to the ability of non-medical individuals to recognize stroke symptoms and make timely decisions, which is critical for improving outcomes. However, data on stroke knowledge and intended care-seeking behavior in Bogotá, Colombia, remain limited. Objective: To assess stroke symptom knowledge and intended care-seeking behavior among adults with hypertension and type 2 diabetes and to identify sociodemographic predictors of limited knowledge and suboptimal...

Stroke
Luisa Fernanda Alviz, Juan Diego Oyola, Juan Diego Martinez-Lemus, Javier Alexander Perez-Lopez, Mariana Medina-Soler, Jaime Eduardo Rodriguez, John Benavides, Carlos Martinez, Claudio Jimenez•
PLOS

The effect of dual task-oriented circuit training on neuroplasticity and walking adaptability in subacute stroke patients: A pilot and feasibility study

Background: Stroke remains a leading cause of long-term disability worldwide, with a substantial proportion of survivors experiencing persistent limitations in functional mobility. Although many individuals regain the ability to walk in structured clinical environments, only a minority achieve independent community ambulation due to cognitive–motor interference (CMI). The subacute phase is characterized by heightened neuroplastic potential and responsiveness to rehabilitation. Dual Task-Oriented...

Stroke
Farida Arisanti, Bejo Ropii, Saniy Ghaida, Tsuchiya Tristiana Dewi, Bernadeta Cahyo Setianingrum Poernomo, Yunia Sribudiani, Lisda Amalia, Julia Patrick Engkasan, Vitriana Biben•
PLOS

OsteoNet-X: A deep residual learning framework for automated osteoporosis detection from knee X-ray images

Osteoporosis is a progressive skeletal disorder characterized by reduced bone mineral density and increased susceptibility to fractures, making early diagnosis essential for effective clinical intervention and long-term patient management. Recent advances in artificial intelligence have demonstrated significant potential for automated bone disease assessment using medical imaging modalities. In this study, a unified deep learning framework, termed OsteoNet-X, is proposed for automated osteoporos...

Osteoporosis
Sudhir Kumar Sangula, S. P. Siddique Ibrahim•
PLOS

Longitudinal changes in BMI and obesity across COVID-19 pandemic periods among underrepresented populations: An analysis of the All of Us dataset

Introduction: The COVID-19 pandemic significantly affected physical activity and lifestyle, potentially increasing Body Mass Index (BMI) and obesity risk. We examined changes in BMI and obesity across Pre-Pandemic, Pandemic Peak, and Peri-Pandemic periods and identified sociodemographic correlates. Methods: We analyzed longitudinal electronic health record data from the All of Us Research Program for adults ≥18 years with at least one BMI record in each period (N = 38,632). Periods were defined...

Obesity
Abdul-Hanan Saani Inusah, Huiyi Xia, Atena Pasha, Zhenlong Li, Andrew T. Kaczynski, Xiaoming Li, Shan Qiao•

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