Clinical intelligence & editorial.

PubMed

Comparison of anticoagulation efficacy and safety of different heparin dosages in cardiogenic shock patients supported by intra-aortic balloon pump: A retrospective cohort study.

The study aimed to evaluate whether a half-dose heparin flush strategy during intra-aortic balloon pump (IABP) support improves safety compared with the standard-dose strategy in patients with cardiogenic shock (CS). In this single-center retrospective cohort study, 128 CS patients who received IABP support between January 2023 and December 2024 were included. Sixty-eight patients received a standard-dose heparin flush, and 60 received a half-dose flush. The primary endpoints were clinically rel...

Anticoagulation

Li Y, Yang W, Yu Y, Fan B, Dong H, Wang Y, Nie H, Hao Z, Wang Z, Niu X, Zhang D• November 6, 2026

PubMed

National and regional allergy and asthma programs: A comparative analysis and lessons for a German National Action Plan For Allergology.

Background: Allergic diseases impose a substantial public health burden, yet Germany lacks a sustained national framework coordinating allergy-related care, prevention, education, research, and evaluation. We analyzed international allergy and asthma programs to identify principles relevant to a German National Action Plan (NAP) for Allergology. Materials and methods: A structured literature and policy review identified national and regional allergy and asthma initiatives through scientific data...

Allergy

Köhler C, Kalb B, Becker S, Klimek L, Lange L, Vogelberg C, Worm M, Hamelmann E• November 5, 2026

PubMed

Artificial intelligence in allergology: A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI), German Academy of Allergy, Clinical Immunology and Environmental Medicine (AeDA) and German Society of Pediatric Allergology and Environmental Medicine (GPA): Part 2.

Background: Although artificial intelligence (AI) is advancing in medicine, its use in allergology remains limited. Because allergic diseases are heterogeneous and clinical, environmental, and molecular data are difficult to integrate, assessment is needed. This second part of a position paper by German allergology societies and associations, led by the German Society of Allergy and Clinical Immunology (DGAKI), establishes a framework for AI in allergology. Materials and methods: The position pa...

Allergy

Pfaar O, Traidl S, Bärhold F, Becker S, Bergmann C, Buters J, Dramburg S, Francuzik W, Gerstlauer M, Hamelmann E, Hernandez Toro CJ, Klimek L, Lange L, Matricardi PM, Pfeffer L, Suarez-Suarez M, Utz P, Wagenmann M, Worm M, Yoosefi M, Mathes S, Seurig S• November 5, 2026

PubMed

Case Report: Uncommon MRI and PET/CT Imaging Findings in a Rare Case of Vertebral Sarcoidosis.

Sarcoidosis is a systemic inflammatory granulomatous disease that can affect almost any body organ. Among the musculoskeletal manifestations, which are uncommon, vertebral sarcoidosis is extremely rare, while depicting a significant variability in radiological features. We present a unique case of a 52‐year‐old male, who was referred for MRI of the lumbar spine due to inflammatory back pain. Disc bulging at the intervertebral spaces L1/L2, L4/L5, and L5/S1 was found, without any signs of spinal...

Sarcoidosis

Hammadi WHH, Varvounis M, Foufa K• November 5, 2026

PubMed

Mitral valve disease in rheumatic heart disease, systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid Arthritis.

Mitral valve disease occurs in rheumatic heart disease (RHD) and selected systemic autoimmune rheumatic diseases, but similar lesions may have different underlying mechanisms. This structured narrative review examines epidemiological, mechanistic, imaging, and management evidence, distinguishing established pathways from incompletely validated mechanisms and hypotheses. In RHD, post-streptococcal valvulitis leads to fibrotic remodeling, commissural fusion, and chordal shortening, producing mitra...

Systemic Lupus Erythematosus

Lucki M, Grygiel-Górniak B, Lucka E, Lesiak M• November 5, 2026

PubMed

Atraumatic Interspinous Bursitis in an Adolescent-A Case Report.

ABSTRACT Cervical interspinous bursitis is an important cause of cervical spine pain, with the diagnosis relying on both clinical findings and higher order imaging in the form of MRI. We present a rare case of exercise‐associated cervical interspinous bursitis in a pediatric patient.

Bursitis

McKenna DP, Davey MS, O'Toole P, Alberghina F• November 5, 2026

PubMed

Crohn's Disease Requiring Different Surgical Interventions in Presumed Monozygotic Twin Brothers: A Case Report.

ABSTRACT INTRODUCTION Crohn’s disease (CD) in both members of a presumed monozygotic twin pair is uncommon. We report twin brothers who developed ileocolonic and perianal CD 2 years apart but required different surgical interventions. This report highlights the value of prompt evaluation of a symptomatic cotwin and individualized surgical decision-making. CASE PRESENTATION Twin 1 developed a perianal abscess at the age of 16 years, followed by severe rectosigmoid inflammation and fixed steno...

Crohn's Disease

Matsunaga K, Matsuda K, Kotani T, Abe K, Kondo R, Omichi K, Nishikawa T, Masuda W• November 5, 2026

PubMed

Beyond the gut: Non-specific interstitial pneumonia in pediatric ulcerative colitis-A rare extra-intestinal manifestation.

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder often presenting with extra‐intestinal manifestations (EIMs) involving the skin, joints and eyes. However, pulmonary manifestation, such as interstitial lung disease (ILD), is a rare complication, particularly in the pediatric population. We report a case of a 10‐year‐old boy, with very early onset IBD‐ulcerative colitis, presented with non‐productive cough, fever and dyspnea, with examination findings revealing respir...

Ulcerative Colitis

Vachher H, Poojari V, Tetarbe S, Chandane P, Shobhavat L, Shah I• November 5, 2026

PubMed

Licoflavone B mitigates allergic rhinitis by restraining epithelial PI3K-AKT/NF-κB NLRP3 inflammasome signaling.

Allergic rhinitis remains highly prevalent and is often incompletely controlled by current therapies, while accumulating evidence implicates epithelial PI3K–AKT/NF-κB-mediated activation of the NLRP3 inflammasome in upper-airway inflammation. This study investigated whether the licorice-derived flavonoid Licoflavone B (LFB) alleviates allergic rhinitis by modulating this signaling axis. In an ovalbumin-induced murine model, allergic rhinitis-like symptoms and nasal histopathological changes were...

Allergic Rhinitis

Shen Q, Ma X, Liu H, Li X, Shao W• November 5, 2026

PubMed

Dupilumab in Atopic Dermatitis - Rate of Poor Responders and Potential Risk Factors from the TREATgermany Registry.

A distinct proportion of patients with atopic dermatitis and dupilumab treatment does not reach the primary endpoint of an eczema area severity index (EASI)-75 or investigator global assessment 0/1 after 16 weeks. Little is known about poor responders to dupilumab in real life scenarios. The study objective was to identify the percentage and characteristics of patients with insufficient treatment response to dupilumab based on “TREATgermany” registry data from dermatological routine care. Betwee...

Atopic Dermatitis

Heratizadeh A, Naim J, Kind B, Loennecke K, Fischer S, Honstein T, Traidl S, Moennig E, Birkner T, Harder I, Mann C, Schaefer T, Abraham S, Augustin M, Ramaker-Brunke J, Pinter A, Meinhardt K, Quist S, Anders S, Schwarz B, Schulz-Kiesow M, Steinke S, Adler N, Handrick C, Schäkel K, Sticherling M, Bong A, Jacobs F, Großmann B, Stahl M, Buerkle CP, Gorriahn-Maiterth H, Biedermann T, Weidinger S, Schmitt J, Werfel T• November 5, 2026

PubMed

Delayed Inflammatory Reaction to Periorbital Hyaluronic Acid Filler: Relapse After Lisinopril Withdrawal and Response to Retreatment.

Dear Editor, Hyaluronic acid (HA) fillers are widely used for facial and extrafacial rejuvenation and generally well tolerated [1]. Delayed inflammatory reactions (DIRs) may present with edema, erythema, induration, or nodules after an uneventful interval [1]. Their pathogenesis remains uncertain and may involve immune responses, filler degradation, and infectious or biofilm‐related factors; reported triggers include viral infections, sinusitis, dental procedures, different or low‐quality fille...

Lisinopril

Bakay ÖSK, Gül B, Kaçar NG• November 5, 2026

PubMed

Biomarker Testing, Imaging, and Outcomes in Cardiology-Referred Acute Breathlessness: A Retrospective Clinical Audit.

Background Breathlessness is a leading cause of emergency hospital attendances, and its multifactorial nature often reflects overlapping cardiopulmonary pathologies such as pulmonary embolism (PE), heart failure (HF), and acute coronary syndrome (ACS). Computed tomography pulmonary angiography (CTPA) is frequently used, often without documented pretest probability assessments. This audit primarily assessed the diagnostic yield of CTPA for suspected PE against the Royal College of Radiologists (...

Cardiology

Mathews J, Riaz RK, Kazi A, Rahman S• November 5, 2026