Clinical intelligence & editorial.

PubMed

Factors Associated With Health Literacy Among Women in Menopause in Western Iran: A Cross-Sectional Study.

Background: There is a lack of information regarding health literacy in homemaker menopausal women in the western Iran. The aim of this study was to investigate factors associated with health literacy among women in menopause who are homemakers in western Iran. Methods: This cross-sectional study was conducted from February 5, 2025 to August 20, 2025, among 350 women in menopause attending comprehensive health service centers in Hamadan, western Iran. The participants were recruited via syste...

Menopause

Jenabi E, Khazaei S, Abdoli S, Javadiyeganeh S• November 6, 2026

PubMed

Urbanicity and Lyme Disease: 20 Year Trends in Incidence and Case Burden in the United States.

ABSTRACT Incidence of Lyme disease (LD) has increased over the last few decades in the United States (US). We examined trends in LD incidence and case burden in high‐incidence jurisdictions in the US from 2000 to 2021 by urbanicity. County‐level counts of confirmed LD cases from 2000 to 2021 were obtained from national surveillance data. Incidence rates were calculated using census population projections. Urbanicity was categorized using Rural–Urban Continuum Codes (RUCC). Mixed effects models...

Lyme Disease

Shafquat M, Gould LH, Kelly PH, Duench SA, Stark JH• November 6, 2026

PubMed

Commonly expressed key driver genes in the pathogenesis of viral and non-viral liver cancer.

Background Hepatocellular carcinoma (HCC) is a common and lethal liver cancer primarily associated with viral infections like hepatitis B virus (HBV) and hepatitis C virus (HCV), as well as non-viral causes. Understanding the molecular mechanisms of these subtypes is essential for identifying potential biomarkers and therapeutic targets. Methods In this study, an integrated bioinformatics approach was used to analyze publicly available datasets related to HBV-associated, HCV-associated, and n...

Liver Cancer

Zamanian M, Bajool N, Haghir-Sharif-Zamini Y, Araban SS, Nassiri F, Mirbahari SN, Ahangar-Parvin R, Shams R, Vosough M, Taleahmad S• November 6, 2026

PubMed

Exploring the Association of Fear, Mental Health, and Lifestyle with Insomnia: A Machine Learning Approach among University Students.

Objective The aim of this study was to identify key predictors of insomnia among university students, focusing on psychological, behavioral, and lifestyle factors. The study also aimed to explore the role of machine learning in identifying insomnia-related patterns and informing personalized intervention strategies. Methods A cross-sectional study was conducted with 576 students from universities in Birjand during the 2023–2024 academic year. Machine learning methods, including Random Forest,...

Insomnia

Khademi S, Saebipour MR, Saadatfar H, Riahi SM• November 6, 2026

PubMed

Global research landscape and emerging frontiers in primary insomnia treatment (2005-2025): A bibliometric analysis.

Background: This study aims to investigate the current state of research on primary insomnia, focusing on key trends and global hotspots. Methods: The Web of Science Core Collection database was used as the primary source for identifying peer-reviewed studies on therapeutic approaches to primary insomnia between 2005 and 2025. CiteSpace analytical tools were employed to examine bibliometric indicators, including temporal publication trends, international collaboration networks, institutional...

Insomnia

Liu J, Li X, Aikebaier G, Lu X, Gu X, Zhang X• November 6, 2026

PubMed

Serum metabolic alterations associated with Chaihu-Longgu-Muli decoction in adolescents with insomnia: An exploratory untargeted metabolomics study.

Adolescent insomnia is common and is frequently accompanied by anxiety and depressive symptoms. Chaihu-Longgu-Muli decoction (CLMD) is used in traditional Chinese medicine prescriptions for insomnia; however, the biological changes associated with CLMD treatment in adolescents remain poorly characterized. This exploratory study investigated clinical symptom changes and corresponding serum metabolomic alterations associated with CLMD treatment in adolescents with chronic insomnia. Adolescents wit...

Insomnia

Xu HY, Meng TW, Zhao R, Huo HM, Fu YJ, Wu XY, Huang JH, Qie R• November 6, 2026

PubMed

Association of the triglyceride glucose-waist circumference index with hypertension among US adults: A cross-sectional study from NHANES.

The triglyceride glucose–weight-adjusted waist index (TyG-WWI), integrating glycolipid metabolism and central obesity, may offer a novel approach to identifying metabolic dysregulation linked to hypertension, yet its association with hypertension among general adults remains inadequately characterized. In this cross-sectional analysis of 2716 adults (aged ≥ 20 years) from the National Health and Nutrition Examination Survey 2015 to 2018, hypertension was defined by self-reported physician diagno...

Hypertension

Peng J, Liu H, Long S, Wei D, Feng L• November 6, 2026

PubMed

Time- and posture-specific management of severe supine hypertension and neurogenic orthostatic hypotension in diabetic autonomic neuropathy: A case report.

Rationale: Coexistence of neurogenic orthostatic hypotension with supine or nocturnal hypertension creates a therapeutic challenge because treatment of either component may aggravate the other. This case illustrates a clinical management framework based on characterization of the full hemodynamic phenotype, repeated reassessment, and treatment adaptation according to posture and time of day, integrating postural blood pressure (BP) responses, 24-hour BP monitoring, symptoms, functional status,...

Hypertension

Šinigoj Porčnik P, Kabaklić A• November 6, 2026

PubMed

Early thyroid-stimulating hormone dynamics as an independent predictor of immune-related hypothyroidism during nivolumab therapy.

Background Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of advanced solid tumors, yet immune-related adverse events remain a major challenge. Thyroid dysfunction is among the most frequent endocrine toxicities associated with programmed cell death-1 (PD-1) inhibitors, often evolving dynamically and remaining early immune-mediated thyroid injury. Identifying an early and reliable biomarker for immune-related hypothyroidism could improve patient monitoring and trea...

Hormone

Çınaroğlu D, Döngelli H, Ataca E, Güç ZG• November 6, 2026

PubMed

Pediatric gigantism due to ectopic growth hormone releasing hormone secretion from a metastatic bronchial neuroendocrine tumor.

Abstract Pediatric gigantism due to ectopic secretion of growth hormone–releasing hormone (GHRH) is exceptionally rare. Most pediatric reports have involved pancreatic neuroendocrine tumors in the context of multiple endocrine neoplasia 1 (MEN1). We describe a female patient diagnosed at 9 years of age with a typical bronchial neuroendocrine tumor and subsequently found to have diffuse hepatic and skeletal metastases, accelerated linear growth, and acromegalic features. Evaluation demonstrated...

Hormone

Vidal-Ostos De Lara F, Sanchis-Pascual D, Hernández-Rienda L, Del Olmo-García MI• November 6, 2026

PubMed

Neonatal compressive goiter as the initial presentation of thyroid hormone resistance with dual THRB and TSHR mutations.

Abstract Resistance to thyroid hormones (RTH) is a rare disorder mostly caused by mutations in the thyroid hormone receptor β gene (THRB). It typically presents in late childhood or adulthood with elevated free thyroid hormone levels, inappropriately normal or high thyroid-stimulating hormone (TSH), and goiter. We report a case of RTH associated with a compressive neonatal goiter. A preterm newborn presented with respiratory distress due to a large goiter (9.7 mL; normal, <1.53 mL) requiring me...

Hormone

Dubois S, Savagner F, Heneau A, Azar-Kolakez A, Al-Amir I, Carel JC• November 6, 2026

PubMed

Screening in Human Genetics - new opportunities, new responsibilities.

Only a generation ago, genetic testing was almost exclusively performed for specific clinical indications: an affected individual, a suggestive family history, or prenatal findings requiring further clarification. In this setting, human genetics primarily served as a diagnostic discipline, helping to establish disease causes, define the chance of recurrence, and support clinical management. Today, genetic analyses are increasingly offered to individuals with the aim of identifying disease predis...

Genetics

Schaaf CP, Rudnik-Schöneborn S• November 6, 2026