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Following the publication of this article [1], concerns were raised regarding Figs 2 and 3. Specifically, Figs 2 and 3 do not appear to match their corresponding captions. The second author stated that Figs 2 and 3 appear in the incorrect order in [1], that the gel image in Fig 2 in [1] should be Fig 3, and that the primer sequences in Fig 3 in [1] should be Fig 2. Please see the corrected figures below. The first author also stated that the gel image in Fig 2 in [1] is incorrect. The correct...
Pcr
Khokhar F, Pickard D, Dyson Z, Iqbal J, Pragasam A, John JJ, Veeraraghavan B, Qamar F, Dougan G, MacQueen H, Rigas S, Holmes M, Mutreja A•
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease is common in severe obesity; however, liver health assessment is inconsistently implemented in specialist weight management services and real‐world data are scarce. This study evaluated the prevalence and severity of vibration‐controlled transient elastography (VCTE)‐defined hepatic steatosis and fibrosis risk in adults attending a UK‐based Tier 3 specialist weight management service, and explored associations with cl...
Weight Management
Willis SA, Ahsan M, Rathi K, Lawrence I, Davies MJ, Webb DR, King JA, Ahmad E•
Luminescence is a powerful method for detecting trace analytes and monitoring biological processes. However, most bioluminescence reagents, including luciferase and its substrates, are sensitive to temperature, limiting their usable shelf lives, and resulting in inconsistent performance. Enhancing the stability of these reagents could reduce signal variability between experiments, simplify workflows, and address cold chain storage issues. In this study, we demonstrate the application of the plat...
Reagents
Radford S, Peris-Taverner Y, Dibble M, Corn K, Zhu T, Martello S, Mayeaux M, Ladd A, Renu S, Chunduri T, Jadhav A, Dart M, Rafat M, Shank-Retzlaff M, Bronsart LL•
Background Hypertension affects more than 1.28 billion adults globally and remains the leading modifiable risk factor for cardiovascular disease, stroke, renal failure, and premature death. This burden is inconsistently distributed across Low- and Middle-Income Countries (LMICs), where nearly three-quarters of adults live with hypertension. This gap is largely driven by poor adherence and low retention. This systematic review aims to assess the effectiveness of nurse-led interventions on retent...
Blood Pressure
Yakob T, Suwanbamrung C, Le CN, Badacho AS, Saengow U•
Purpose The Respire−21 study found that early obstructive sleep apnea (OSA) diagnosis and treatment is associated with improved neurocognitive and behavioral outcomes in infants with Down syndrome (DS) followed from 6 to 36 months of age (screened group) versus a control group receiving standard care at 36 months of age (standard care group). This follow-up study assessed whether these benefits persisted at 60 months of age and whether early OSA treatment influenced language and communication o...
Sleep Apnea
Mircher C, Falquero S, Sacco S, Couloigner V, Amaddeo A, Ravel A, Montagutelli D, Prioux E, Toulas J, Marey I, Luscan R, Clert M, Martet D, Caillaud MA, De Sanctis L, Khirani S, Walti H, Fauroux B•
Summary Our findings suggest that although pregnancy and lactation are periods of physiological calcium loss, higher parity is not associated with an increased risk of postmenopausal osteoporosis; rather, it appears to confer a long-term protective effect. Purpose Osteoporosis is a significant public health burden. While parity induces transient bone loss, their long-term skeletal impact remains poorly understood. This study aimed to clarify the associations between parity, defined as the num...
Osteoporosis
Yuan W, Liao J, Tao L, Song H, Wang H, Huang J, He J, Liu H, Wu T, Zhou H, Zhang Y, Song C•
Aim Rimegepant and lasmiditan are effective acute migraine treatments, but real-world head-to-head comparative data are lacking. We aimed to compare their effectiveness and tolerability in clinical practice. Methods This post-hoc study indirectly compared two prospective, multicenter, real-world studies (GAINER and DART). Participants treated up to four migraine attacks with rimegepant 75 mg orally disintegrating tablets or lasmiditan 50 or 100 mg. Data were collected using an electronic diar...
Migraine
Vaghi G, Iannone LF, Sebastianelli G, Piella EM, Corrado M, Romozzi M, De Santis F, Ornello R, Pistoia F, De Cesaris F, Burgalassi A, Coppola G, Silvestro M, Rainero I, Volta GD, Montisano DA, Guerzoni S, Prudenzano MP, Mascarella D, Avino G, Mampreso E, Valente M, Battistini S, Granato A, Albanese M, Trimboli M, Doretti A, De Icco R, Italian Headache Registry (RICe) Study Group•
ABSTRACT Incomplete image‐guided ablation can promote local tumor progression by reshaping the residual tumor microenvironment toward immunosuppression, yet noninvasive biomarkers of this process remain limited. Here, a translational multiparametric PET/MRI strategy was developed to monitor macrophage‐associated microenvironmental remodeling after incomplete microwave ablation (iMWA) in orthotopic VX2 liver tumors. Twenty‐four tumor‐bearing rabbits were assigned to untreated control, early post...
Liver Cancer
He Y, Xu H, M M Rogasch J, Berndt N, Guo J, Schellenberger E, Häckel A, Heidemann L, Hesse F, Liu Y, Ramtke J, Beindorff N, Hofheinz F, Kader A, Mülleder M, Textoris-Taube K, Hamm B, Müller DN, Schmidt R, Hauptmann R, Traub H, Schannor M, Savic LJ•
Abstract Inbreeding depression decreases the fitness of progeny resulting from mating between related individuals. The sex-specific response to inbreeding remains unknown in haplodiploid organisms, which have haploid males and diploid females. This research examines the consequences of inbreeding using 2 different inbreeding protocols: full-sib (brother–sister, BS) and maternal backcross (mother–son, MS) on life history, demographic variables, growth in population size, and morphological stabil...
Background Autism spectrum disorder (ASD) is the most complex neurodevelopmental disorder with impairments in communication, social interaction and stereotyped behaviours. ASD has been found to increase immeasurably in India, with estimates ranging from 1 in 68 to 1 in 100 children. Genetically, more than 1,000 genes have been linked with ASD. Among them, the neuronal cell adhesion molecule (NrCAM) gene is one of the candidate genes and is important for its critical role in the development and...
Abstract Objectives To describe and evaluate a needs-assessment informed model for embedding a non-allergist penicillin allergy de-labelling (PADL) service within an Acute Medical Unit (AMU), including stakeholder experience. Methods A four-phase quality improvement project in one UK AMU, reported per SQUIRE 2.0. Phase 1: needs-assessment survey of 124 staff (pharmacists, doctors, nurses, immunology staff). Phase 2: a multidisciplinary team translated Phase 1 barriers into a PEN-FAST-guided...
Allergy
Toner P, Glass A, Donnelly C, Garnett K, Mchaffie M, Quinn S, Hillen C, Mullan J, Mustafa YH, Maguire C, Faulkner S, Ng B, Brady A•
Pediatric inflammatory bowel disease (IBD) patients are at increased risk for Clostridioides difficile infection. This review highlights bile acid dysmetabolism, driven by gut microbiota dysbiosis and reduced microbial production of secondary bile acids, as a key factor linking pediatric IBD to increased CDI susceptibility. We examine interactions among IBD, dysbiosis, bile acid metabolism, and C. difficile, and discuss emerging microbiome-based interventions aimed at restoring bile acid homeost...
Inflammatory Bowel Disease
Rowe JC, Winston JA•
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