Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Nature’s mother holds many untapped treasures of phytoconstituents that can cure and exhibit unexpected therapeutic activity against several diseases. Seeds of velvet beans, popularly known as Mucuna pruriens (MP), are the richest source of Levodopa (L-DOPA). L-DOPA is the precursor for dopamine, a key neurotransmitter deficient in the brain of patients suffering from Parkinson’s disease (PD). The peripheral degradation of L-DOPA before crossing the blood-brain barrier (BBB) is the greatest chal...
Selenium
Sahoo SS, Modak S, Sahu PK, Behera A, Ranch KM, Swain RP•
Dear Editor, Clinicians routinely advise patients with fibromyalgia and obesity to lose weight, expecting symptomatic benefit. Yet this recommendation remains nonspecific, as we lack a clear understanding of how much weight loss is required for a clinically relevant benefit. Rheumatology has embraced a treat-to-target philosophy, defining quantitative goals that guide management in rheumatoid and psoriatic arthritis and increasingly framing obesity itself as a modifiable target with defined thre...
Background Motivation towards behavior change is an important determinant of long-term weight management. Previous research demonstrates that children’s and adolescents’ motivation can be increased through participation in weight management programs. However, little is known about motivational changes in caretakers of children and adolescents with overweight and obesity despite their recognized role as “agents of change” in pediatric weight management. The study aims to compare motivational cha...
Weight Management
Herschbach A, Junne F, Erschens R, Ehehalt S, Jacoby J, Martus P, Mack I, Weiland A, Krauß I, Greule C, Sudeck G, Zurstiege G, Wels A, Adam SH, Hoell A, Bethge W, Ums M, Sammet T, Reyer M, Schliesing O, Zipfel S, Gawrilow C, Giel KE, Ziser K•
Abstract Ischemic stroke (IS) remains a leading cause of death and long-term neurological disability worldwide, and current treatment options are constrained by narrow therapeutic windows and limited neuroprotective efficacy. Accumulating evidence implicates the microbiota-gut-brain axis (MGBA) in the development and progression of IS. Following cerebral ischemia, bidirectional communication between the brain and gut is disrupted, resulting in gut microbial dysbiosis, impaired intestinal barrie...
Stroke
Jia X, Zheng X, Tu R, Lyu P, Chen X, Zhang M, Bu N, Wang Y, Bai Y, Wang S•
Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections (ARI), yet evidence from outpatient settings, particularly among older adults, remains limited. Methods BUCOSS was a prospective observational study conducted across three consecutive respiratory seasons (2022–2025) in patients aged ≥ 60 years with ARI, recruited from 29 primary care and office-based pulmonology practices. RSV and other respiratory pathogens were identified via multiplex polymerase...
Respiratory
Hinze CA, Barten-Neiner G, Eberhardt F, Reeves R, Marijic P, Stierl M, Martens B, Wyen C, Landgraf I, Freye M, Knaupp T, Ammenwerth W, Schmidt P, Panning M, Diel R, Rohde G•
Background Migraine is a disabling neurological disorder that significantly impairs quality of life and imposes a substantial socioeconomic burden. While acupuncture has shown clinical benefits for migraine management, the scope and methodological quality of the existing evidence remain unclear. This scoping review aimed to map the current landscape of clinical research on acupuncture for migraine, characterize the evidence base, identify research gaps, and inform future research priorities. M...
Migraine
Wu Y, Ji Y, Wu Y, Li W, Zhang J, Yao C, Li Z, Xiao B•
Purpose Academicians in higher education are positioned as authoritative knowledge bearers, yet their own mental health remains comparatively unexamined by research, which has instead focused predominantly on students. This creates a conceptual and literature blind spot around a population that experiences personal distress despite its revered status. The purpose of this study is therefore to examine how academicians at Malaysian public universities experience and make sense of their mental hea...
Mental Health
S Senathirajah ARB, Sivagurunathan R, Haque R, Qazi S, Qayyum S, Sun J, Ng PK•
Purpose Psychological distress is common among women undergoing assisted reproductive technology (ART). Perceived social support, insomnia, and health information literacy may be interrelated with psychological distress during fertility treatment, but their conditional relationships remain insufficiently understood. This study examined the indirect association between perceived social support and infertility psychological distress through insomnia and whether health information literacy moderat...
Insomnia
Jiang L, Wu M, Yao J, Yang L, Yang J, Yuan M, Zhang K, Zhang Q, Zhao M, Zeng T•
Dear editor I read with interest the cross-sectional study by Hu et al, which examined intergenerational support, social networks, attitudes toward aging, and depressive symptoms among 1157 older adults in China. The integration of familial and social resources is thus valuable. However, several inconsistencies in the published descriptive and mediation results warrant clarification.1 First, the published total means do not equal the sums of their corresponding component means. The intergenera...
Background The association between remnant cholesterol inflammatory index (RCII) and cardiometabolic multimorbidity (CMM) remains unclear. RCII is defined as: {Total Cholesterol − (High-Density Lipoprotein Cholesterol + Low-Density Lipoprotein Cholesterol)] × High-Sensitivity C-Reactive Protein/10}. This study examined the association between baseline RCII and CMM among middle-aged and older adults in China. Material/Methods This study analyzed data from the China Health and Retirement Longit...
Cholesterol
Wang Y, Dong Q, Wang W, Tang S, Yu N, Wang Y, Zou C•
Introduction Musculoskeletal complaints are a frequent cause of pediatric emergency visits. While adolescent back pain is typically benign, it can occasionally signal underlying malignancy. Distinguishing organic pathology from functional disorders is particularly challenging in patients with pre‐existing psychiatric comorbidities, leading to potential diagnostic delays. Case Presentation We report a 17‐year‐old female with a history of anxiety and depression presenting with two weeks of seve...
Back Pain
Huang T, Meng L, Zheng L, Han X, Ansa-Addo E, Hong F•
Abstract Objectives Methotrexate (MTX) is the first-line treatment for rheumatoid arthritis (RA), yet inadequate response is reported in 30–40% of patients. Predicting MTX response early could enable more personalized and effective treatment. This study aimed to identify biomarkers predictive of MTX response at 6 months through whole-blood transcriptomic signatures using machine learning. Methods RNA sequencing data were generated in whole-blood samples taken from 100 MTX-naive RA patients a...
Arthritis
Yap CF, Nair N, Verstappen SMM, Hyrich K, Barturen G, Rivas-Torrubia M, Gut M, Gut I, Alarcón Riquelme ME, Barton A, Plant D, RAMS Co-Investigators•
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