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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,813–1,824 of 1,994 articles

PubMed

Neurotized Free Anterolateral Thigh Flap for Large Tissue Defect and Joint Exposure in the Setting of Olecranon Bursitis: A Case Report.

Elbow wounds secondary to septic olecranon bursitis are a challenging problem to treat. Neurotized fasciocutaneous free anterolateral thigh (ALT) flaps provide a reliable soft tissue coverage option with the opportunity to provide protective sensation to a common pressure point. Free flaps can provide coverage when alternative options lower on the reconstructive ladder are unavailable. A 69-year-old man with rheumatoid arthritis presented with septic olecranon bursitis requiring serial debrideme...

Bursitis
Zeyl VG, Mahajan AY, Loewenstein SN•
PubMed

Prognostic utility of interim (18)F-FDG PET/CT after two cycles of ABVD in response assessment in Hodgkin's lymphoma patients: single-center preliminary experience.

Objective(s): This study evaluates the utility of interim 18F-FDG PET/CT (iPET)-guided therapy in a Southeast Asian population, addressing gaps in region-specific data. Key outcomes included treatment response rates and progression-free survival (PFS) stratified by iPET results (Deauville score (DS) 1-3 vs. 4-5) across all clinical risk groups (including early-stage favorable/unfavorable and advanced-stage based on the International Prognostic Score (IPS)). Findings will inform optimal risk-ada...

Hodgkin's Lymphoma
Toan NQ, Thai PV, Dung LT, Son MH, Son PL, Nga DH, Quang LV, Ha LN•
PubMed

Risk of Type II Diabetes Mellitus Among B-Cell Non-Hodgkin's Lymphoma Survivors.

ABSTRACT Purpose Advancing therapies have increased B‐cell Non‐Hodgkin's Lymphoma (B‐NHL) patient survival. However, data are limited on the risk of type II diabetes mellitus (type II DM) in adult survivors following treatment. This study examines the risk of type II DM among a Utah population of B‐NHL survivors, compared to the general population. Methods A cohort of 3529 adult survivors diagnosed with B‐NHL in Utah between 1997 and 2013 in the Utah Cancer Registry and 13,339 individuals fr...

Non-Hodgkin's Lymphoma
Chi E, Chang DK, Chang CE, Kim S, Park J, Snyder J, Deshmukh V, Newman MG, Lee CJ, Hashibe M•
PubMed

Crohn's Disease Phenotype in a Patient With Severe Congenital Neutropenia Caused by CSF3R Variants: Exploring the Pathogenesis and Effects of Thalidomide Treatment.

This study describes a case of severe congenital neutropenia (SCN) harboring biallelic CSF3R variants and presenting with a novel inflammatory bowel disease (IBD) phenotype that responded remarkably to thalidomide. We performed functional studies to reveal the pathogenicity of the CSF3R and to elucidate the potential mechanisms underlying the therapeutic effects of thalidomide. A comprehensive review of the literature identified 18 reported cases of SCN associated with CSF3R variants. We subsequ...

Crohn's Disease
Wang Y, Wang L, Pan C, Huang Z, Li P, Qiu X, Zheng C, Huang Y•
PubMed

CD27 and GZMK as Co-Biomarkers in Rheumatoid Arthritis and Crohn's Disease and Mediate Immune Imbalance.

Background Studies have found similar immune responses, genetic susceptibility, and inflammatory mediators between Rheumatoid arthritis (RA) and Crohn’s disease (CD), but these findings are controversial. Methods The Gene Expression Omnibus (GEO) was utilized to get microarray data. Differentially expressed genes (DEGs) in individuals with CD and RA were identified. Weighted gene co-expression network analysis (WGCNA) was used to identify key modular genes in CD and RA. The least absolute shr...

Crohn's Disease
Zheng L, Zeng Y, Fang M, Heng H, Luo Y, Zhong J•
PubMed

Integrative eQTL and Mendelian Randomization Analyses with Experimental Validation Prioritize Genetic Candidate Biomarkers for Crohn's Disease.

Introduction Crohn's disease (CD) is a chronic, idiopathic inflammatory bowel disease. Understanding the genetic and immunological basis of CD can lead to better therapeutic strategies. Methods We employed publicly available datasets from the Gene Expression Omnibus (GEO) database to identify instrumental variables through expression quantitative trait loci (eQTL) analysis and conducted two-sample Mendelian randomization (MR) analyses. Additionally, we investigated the functions and pathways...

Crohn's Disease
Zhang X, Liu L, Xu W, Li G, Qin Q, Zhang J•
PubMed

Association between Suicidal Ideation and Immune Parameters in First-episode Patients with Schizophrenia.

Introduction Disturbed immunity and inflammation have been associated with the pathogenesis of schizophrenia (SZ) and suicidal behaviors. We hypothesized that the neutrophil-to-lymphocyte ratio (NLR) was associated with the increased risk of suicide ideation (SI) in patients with SZ. Methods A total of 97 drug-naïve first-episode patients with SZ (15 with SI and 82 without SI) were recruited in the present study. The symptom severity was assessed using the Positive and Negative Syndrome Scale...

Schizophrenia
Xia Y, Guan X, Xiu M, Wu F•
PubMed

Lurasidone vs. Other Antipsychotics as Augmentation Strategies for Clozapine in Treatment-resistant Schizophrenia: An Observational Multicenter Prospective Study.

Introduction Clozapine, after its introduction, reshaped the landscape of Treatment-Resistant Schizophrenia (TRS) treatment, becoming the first-line treatment for that condition. However, many patients fail to respond to this drug alone. Clozapine-resistant schizophrenia (CRS) is associated with a more severe clinical presentation than TRS, manifesting in exacerbated symptoms and significantly diminished quality of life. The complex nature of CRS has prompted the development of augmentation str...

Schizophrenia
Prodi T, Benatti B, Grecchi A, Oresti M, Mazzoni F, Carnevale Miacca G, Brondino N, Dell'Osso B, Olivola M•
PubMed

Adverse Drug Reactions of Low and Standard Doses of Risperidone in Schizophrenia Outpatients.

Introduction Risperidone is an atypical antipsychotic commonly used in the treatment of schizophrenia. Despite its effectiveness, several adverse drug reactions can be bothersome to patients. This study aimed to examine the prevalence and characteristics of adverse effects in outpatients with schizophrenia treated with low (<4 mg/day) and standard (≥4 mg/day) doses of risperidone. Methods A cross-sectional study was conducted with 64 patients at a tertiary psychiatric hospital. Data on advers...

Schizophrenia
Boonlue T, Karnkla P, Jansela S, Werawattanachai C•
PubMed

Dissociable anterior and posterior beta-burst dynamics track thought disorder in schizophrenia.

Background Thought disorder in schizophrenia likely reflects disrupted maintenance of internal models during predictive processing. Beta oscillations have been proposed to index top-down predictive signalling, but prior resting-state studies have focused on spectral power, overlooking transient burst dynamics that potentially stabilize and reinstate internal representations, especially in the default mode network (DMN). Methods Resting-state magnetoencephalography was acquired from 25 patient...

Schizophrenia
Wei H, Power L, Dou R, Baillet S, Palaniyappan L•
PubMed

Shen-Ling-Bai-Zhu-San Mitigates Ulcerative Colitis by Enhancing Intestinal Barrier Integrity via the AhR-CYP1A1-NF-κB Signal Pathway.

Introduction Ulcerative Colitis (UC) represents a persistent inflammatory disorder of the colon, typically characterized by abdominal discomfort, diarrhea, and blood stools. Shen-Ling-Bai-Zhu-San (SLBZS), a traditional Chinese herbal formula, has shown clinical efficacy in alleviating symptoms such as abdominal bloating, frequent loose stools, and diarrhea. Nonetheless, the precise molecular mechanisms underlying its therapeutic effects remain largely unclear. Methods UPLC-QE-MS combined with...

Ulcerative Colitis
Ming L, Chen J, Ma J, Guo S, Xu K, Ji J, Zhao Z, Xu S, Huang Q•
PubMed

Genome-wide Association Studies of the Pathogenic Sphingosine-1-Phosphate Gene in Ulcerative Colitis.

Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that can lead to malignancies over time. Sphingosine-1-phosphate (S1P) receptor signaling affects lymphocyte trafficking and vascular integrity, influencing intestinal inflammation. This study aimed to identify S1P-related key genes in UC. Methods Differentially expressed genes (DEGs) between the UC and control groups were analyzed in the GSE87473 (training) dataset. Genes overlapping between the DEGs and S1P-related g...

Ulcerative Colitis
Chen H, Shang J, Zhao S, Xu L, Shen H•

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