Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Background Ulcerative colitis (UC) is a complex disease associated with immune dysregulation. Classic prescriptions (CP) of traditional Chinese medicine have a strong theoretical foundation and a long history of clinical use in treating UC. This study aims to uncover the intrinsic patterns and characteristics of these CPs. Methods Data mining of CP literature for UC from VIP, CNKI, WanFang, and PubMed (2013–2023), which focused on herb usage frequency, properties, flavors, meridian tropisms,...
Background Inflammatory bowel disease (IBD) encompasses chronic gastrointestinal disorders that significantly impact patients’ quality of life (QoL). While clinical trials support the efficacy and safety of vedolizumab, real‐world data linking its effectiveness to QoL‐related patient‐reported outcomes remain limited. This prospective observational study assessed the effects of 14‐week vedolizumab induction therapy on QoL (i.e., fatigue, mood, and sleep disturbances), clinical response, safety,...
Ulcerative Colitis
Michalak A, Zawada I, Deskur A, Kopertowska-Majchrzak M, Talar-Wojnarowska R, Domżał-Magrowska D, Eder P, Stawczyk-Eder K, Waszak K, Rydzewska-Wyszkowska G, Maciejewska K, Karłowicz K, Gąsiorowska A, Kaczka A, Konecki Ł, Krogulecki M, Filipiuk A, Kłopocka M, Liebert A, Hartleb M, Gawron-Kiszka M, Poniewierka E, Gromny I, Zagórowicz E, Filip R, Majewska E, Cichoż-Lach H•
Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease strongly associated with ulcerative colitis (UC). Although uncommon, PSC‐associated ulcerative colitis (PSCUC) represents a distinct subtype of inflammatory bowel diseases characterized by a higher risk of colorectal and hepatobiliary cancers. Early diagnosis remains a challenging issue because of the lack of specific biomarkers. Bioinformatic analysis of Gene Expression Omnibus (GEO) datasets identified potential, s...
Ulcerative Colitis
Asadi Sarabi P, Beheshti-Maal A, Judaki AA, Teymoorian SK, Hashemian Z, Rismani E, Gul A, Malekzadeh R, Hassan M, Vosough M•
Background Ulcerative colitis is an inflammatory intestinal tract disease that is complex and difficult to heal, and prone to recurrence. The Fuzi-Baijiangcao (FB) herb pair is a commonly used drug combination for the clinical treatment of UC in China. However, its underlying mechanisms have not been elucidated. In this study, we explored the active ingredients of the FB herb pair and its potential mechanisms in the treatment of UC. Methods Firstly, the active ingredients and potential target...
Background: Granuloma Annulare (GA) is a chronic inflammatory dermatosis with diverse presentations, yet comprehensive data integrating histopathology, long-term prognosis, and systemic inflammatory markers remain limited. This study aimed to analyze these clinicopathological characteristics and identify biomarkers for chronicity and recurrence. Methods: In this retrospective cohort study, we evaluated 34 patients with histopathologically confirmed GA diagnosed between 2013 and 2023. Demographic...
Background Knee osteoarthritis (KOA) is a common chronic degenerative joint disease. Its rising incidence, driven by population aging and increasing obesity rates, imposes a growing socioeconomic burden. As a therapy integrating the dual merits of acupuncture regulation and thermal stimulation, warm acupuncture has been widely adopted for KOA, accompanied by a growing body of relevant research. However, standardized recommendations regarding optimal treatment frequency and course duration of wa...
Osteoarthritis
Deng H, Su Q, Wang Y, Wang J, Liu K, Fu L, Li S, Xu S, Mi Y•
Introduction Osteoarthritis (OA) is a leading cause of disability, and emerging evidence highlights the gut–joint axis as critical in its pathogenesis and therapy. To date, no bibliometric synthesis has comprehensively mapped this field. Methods We searched the Web of Science Core Collection (2008–2025) for original studies on gut microbiota and OA. Bibliometric and network analyses were performed using bibliometrix (R) and VOSviewer to assess publication trends, citations, collaborations, an...
Allergic rhinitis (AR) is a chronic inflammatory disorder of the upper airways that is mediated by immunoglobulin E (IgE) and triggered by environmental allergens. Current pharmacological therapies, including antihistamines, corticosteroids, and immunotherapy, offer symptomatic relief but are limited by their incomplete disease‐modulating effects and potential adverse side effects. Purinergic P2 receptors (P2Rs; P2X and P2Y subtypes) have emerged as key modulators of allergic inflammation and re...
Background Allergic rhinitis (AR) is a prevalent chronic inflammatory nasal disorder with suboptimal current therapies. Glycyrrhizic acid (GA), a bioactive triterpenoid from Glycyrrhiza uralensis, exerts well‐documented antiinflammatory effects, and preliminary evidence indicates its efficacy in alleviating airway inflammation in AR models. However, two critical knowledge gaps remain unaddressed: whether GA directly binds to core proteins of the toll‐like receptor 4 (TLR4)/nuclear factor‐kappa...
Serum‐specific IgE (sIgE) and skin prick testing (SPT) have limitations in diagnosing allergic rhinitis (AR). CD63, a mast cell activation biomarker reflecting degranulation extent, has unclear application in AR diagnosis. This study developed a functional mast cell activation test (MAT) for the in vitro diagnosis of AR by quantifying CD63 expression on LAD2 cells stimulated with patient serum and specific allergens. The assay was evaluated in 128 AR patients and 115 controls. The assay showed g...
Allergic Rhinitis
Pan J, Gong L, Xu J, Luo S, Wang C, Liu R, Zhang T, Zhang M•
Type 2 diabetes mellitus is a chronic metabolic disorder associated with microvascular and macrovascular complications. Hyperglycemia and insulin resistance are core pathophysiological components of diabetes, linked to subclinical inflammation and persistent oxidative stress, which result in endothelial dysfunction and subsequent atherogenesis. Nowadays, several arrows in the diabetologist's quiver are available for the management of diabetes, providing flexibility and the ability to adopt a per...
Type 2 Diabetes Mellitus
Kalogeris A, Ikonomidis I, Kyriakoulis KG, Pavlidis G, Thymis J, Katogiannis K, Kountouri A, Pliouta L, Pililis S, Korakas E, Lambadiari V•
Aim This review aims to explore the pathophysiological mechanisms by which SARS-CoV-2 affects lipid metabolism and the metabolome in patients with Type 2 Diabetes Mellitus (T2DM). It compares these alterations with those observed in non-diabetic individuals and proposes strategies to mitigate potential long-term metabolic complications. Methods A narrative review was conducted using PubMed, Scopus, and Google Scholar to identify studies published between 2004 and 2025 concerning adult T2DM pa...
Cookies on POR. Essential cookies keep the site working. With your permission, optional analytics cookies help us understand how the site is used. We do not send your POR account identity to Google. Read the privacy policy.
