Clinical intelligence & editorial.

PubMed

Chain Mediating Role of Illness Perception and Fear of Hypoglycemia in Impaired Hypoglycemic Awareness and Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.

Introduction Impaired hypoglycemic awareness (IAH) in type 2 diabetes mellitus (T2DM) is linked to mild cognitive impairment (MCI), but the underlying mechanisms are unclear. This study aimed to explore the chain mediating role of two psychological factors, illness perception (IP) and fear of hypoglycemia (FOH), in the relationship between IAH and MCI. Methods A cross-sectional survey of 251 T2DM patients was conducted using convenience sampling at two tertiary hospitals. Data on IAH, IP, FOH...

Type 2 Diabetes Mellitus

Han M, Li X, He Y, Kan Y, Wan X, Liu L, Su Y, Chen J, Fang L, Wang J, Zhang Y• January 1, 2026

PubMed

Major depressive disorder is associated with reduced intrinsic connectivity between the bed nucleus of the stria terminalis and ventral striatum.

Background: The bed nucleus of the stria terminalis (BNST) plays a critical role in the neural processing of negative emotions. To date, no studies have investigated whether intrinsic connectivity of the BNST is associated with major depressive disorder (MDD) or with the severity of clinical symptoms in individuals with depression. Methods: Resting-state functional magnetic resonance imaging (7 Tesla (7T)) with seed-to-voxel-analysis was used to compare the intrinsic connectivity of the BNST...

Major Depressive Disorder

Gorka A, Evans J, Kvarta M, Ballard E, Zarate C• January 1, 2026

PubMed

Quality of Service and Cost of Managing an Episode of Major Depressive Disorder: A Cohort Study in Iran.

Background: Major depressive disorder (MDD), a major cause of the burden of diseases, is associated with a considerable rate of inadequate treatment and high costs. We assessed the pattern of service use, quality, and costs of healthcare for MDD in Iran. Methods: We assessed a national sample of 265 patients in the acute phase of MDD recruited from outpatient/inpatient settings at baseline and in three follow-up points of one, three, and six months. The pattern of service use and selected qua...

Major Depressive Disorder

Amin-Esmaeili M, Baheshmat S, Rahimi-Movaghar A, Samimi Ardestani SM, Samadi R, Hajebi A, Farzy Y, Moghimi-Sarani E, Khatibzadeh S, Shahraz S• January 1, 2026

PubMed

Mendelian Randomization Studies of Major Depressive Disorder, Schizophrenia, Bipolar Disorder, and Cancers: A PRISMA Review and Meta-Analysis.

Introduction Previous literature has reported ambiguous results regarding the association of severe psychiatric disorders and an increasing risk of cancer disease. The aim of our analysis was to explore any associations between severe psychiatric disorder (SPD), like schizophrenia (SCZ), Bipolar Disorder (BD) and recurrent major depression (MDD), and cancer diseases by meta-analyzing Mendelian Randomization (MR) studies available in the current literature. Methods The present systematic revie...

Major Depressive Disorder

Vitale E, Maistrello L, Rizzo A, Santoni M, Motamed-Jahromi M, Sallustio A, Tramacere F• January 1, 2026

PubMed

Tempol Ameliorates Psoriatic Skin Inflammation: Evidence of TLR4/NF-κB/Nrf2 Axis Modulation.

Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, immune dysregulation, oxidative stress, and impaired epidermal barrier function. In the present study, we investigated the protective effects of Tempol, a membrane‐permeable nitroxide with antioxidant and anti‐inflammatory properties, using several psoriasiform models. In HaCaT keratinocytes, stimulation with a cytokine mixture significantly induced inflammatory responses. Tempol (0.5 and 1 mM) sh...

Skin Inflammation

Scuderi SA, Lanza M, Capra AP, Catalfamo A, Esposito E, Ardizzone A• January 1, 2026

PubMed

STAT3 ablation in keratinocytes ameliorates allergic contact dermatitis in DNCB-induced mice model.

Objective(s): Allergic contact dermatitis (ACD) is a T cell-mediated type IV hypersensitivity reaction to haptens. Its pathogenesis involves keratinocyte dysfunction and dysregulation of the Signal Transducer and Activator of Transcription 3 (STAT3)-signaling pathway. However, the specific role of keratinocyte produced STAT3 in ACD remains unclear. To investigate the effect of keratinocyte (KC)-specific STAT3 conditional knockout on 1-Chloro-2,4-dinitrobenzene (DNCB)-induced ACD in mice. Mater...

Contact Dermatitis

Chen L, Zhang C, Li L, Wang H, Yao W, Xing L, Gao J, Li Z, Tian F• January 1, 2026

PubMed

Topical Trichosanthis Radix Water Extract Attenuates Atopic Dermatitis-Like Skin Inflammation: Marker Standardization, Network Pharmacology, and Preclinical Validation.

Trichosanthis Radix (TR) is a pharmacopeial crude drug traditionally used to clear heat, reduce swelling, expel pus, and generate fluids, suggesting potential relevance to inflammatory skin disorders such as atopic dermatitis (AD). In this study, we evaluated the AD‐related activity of a TR water extract using an integrated workflow combining network‐based target analysis, marker compound analysis, and experimental validation in vivo and in vitro. The overlap between predicted TR targets and AD‐...

Atopic Dermatitis

Kim HM, Kim GL, Gil TY, Sim HY, Lee H, Lee DS, Lee KY, An HJ• January 1, 2026

PubMed

Population-Level Burden of Dermatitis and the Effects of Moxibustion and Capsaicin on Pruritus and JAK/STAT Signaling in Atopic Dermatitis: A Multilevel Study.

Purpose This study comprised two complementary levels of investigation. First, we characterized the global burden, temporal trends, and socioeconomic inequalities of dermatitis as an aggregated disease category. Second, within this broader public‐health context, we investigated whether moxibustion and topical capsaicin alleviate pruritus and inflammatory skin damage in a rat model of atopic dermatitis (AD) and explored their potential convergent regulation of the Janus kinase (JAK)/STAT signali...

Atopic Dermatitis

Yang Y, Guo L, Yang Y, Tang H, Kuang H, Lin L, Gou Y, Li S, Zhao H• January 1, 2026

PubMed

Mechanistic Study of Yibi Decoction in Treating Rheumatoid Arthritis via Modulating the JAK2/STAT3 Signaling Pathway.

Introduction/Objective To investigate the therapeutic effects of Yibi Decoction (YBD) in rheumatoid arthritis (RA) and to elucidate the underlying mechanisms, with a particular focus on the JAK/STAT signaling pathway. Methods Network pharmacology analysis was employed to predict the bioactive compounds and potential therapeutic targets of Yibi Decoction. A collagen-induced arthritis (CIA) rat model was established to validate the predicted effects in vivo. Western blotting, enzyme-linked immu...

Rheumatoid Arthritis

Huang C, Chen S, Chen Y, Xia T• January 1, 2026

PubMed

Therapeutic Potential of Phellodendrine/ Atractylenolide-I Combination in Rheumatoid Arthritis: Targeting Neutrophil Apoptosis through LTB4/BLT1 Pathway Suppression.

Introduction To investigate the therapeutic effects of rheumatoid arthritis (RA) Phellodendrine and Atractylenolide-I (PHE/ATL-1) on RA and their mechanisms. Methods In this study, first clinical experiments were conducted to investigate whether the delayed neutrophil apoptosis in the course of RA was related to the Leukotriene B4 (LTB4)/ Leukotriene B4 receptor 1 (BLT1) pathway, and then the effects of PHE/ATL-1 inhibition of the LTB4/BLT1 pathway to promote neutrophil apoptosis to inhibit i...

Rheumatoid Arthritis

Qin Z, Tang R, Jiang G, Yin J, Xu S, Wang Q, Cai K, Liang J, Zhang M, Jia X• January 1, 2026

PubMed

Revealing Metabolic Reprogramming Genes as Biomarkers of Rheumatoid Arthritis: A Bioinformatics Study Based on Ensemble Learning Approach and Single Cell RNA Sequencing.

Introduction Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Emerging evidence suggests that metabolic reprogramming plays a pivotal role in rheumatoid Arthritis (RA) pathogenesis. However, existing studies have focused predominantly on isolated pathways. This study aimed to systematically investigate the molecular interplay between metabolic reprogramming and immune dysregulation in RA. Methods Twe...

Rheumatoid Arthritis

Cheng L, Zong H, Li D, Qian L• January 1, 2026

PubMed

Randomized comparison of continuous versus intermittent bolus furosemide in neonatal heart failure.

Background and Aims: In term neonates with heart failure, optimizing diuresis is critical, yet evidence for best practice is sparse. This study aims to compare the effectiveness of continuous infusion versus intermittent bolus furosemide in improving pulmonary status, hemodynamics, renal function, and intensive care unit (ICU) length of stay in neonates with heart failure. Materials and Methods: A randomized trial was conducted involving 52 infants (26 per group) to compare continuous infusio...

Furosemide

Ahmadipour M, Razi L, Jamali Z, Allahdini I, Ahmadi HF• January 1, 2026