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ABSTRACT Introduction Insomnia and other sleep disorders are becoming increasingly prevalent worldwide, while current sedative medications such as benzodiazepines, though effective, are often limited by side effects and dependency risks. Therefore, identifying safe natural compounds with sedative potential is of growing scientific and clinical interest. L‐quebrachitol (LQL), a naturally occurring cyclitol compound with antioxidant, antimicrobial, and antidiabetic properties, has not been previ...
Diazepam
Asrafi A, Aslam M, Al Hasan MS, Uddin MB, Mia E, Alshahrani MY, Bithi SA, Akter MS, Hossain MA, Islam MT•
In obstetrics, diazepam is commonly used to treat anxiety, insomnia and as a second‐line treatment for seizures in preeclampsia and eclampsia. However, the effects of diazepam on the oxidative balance and vascular function of the umbilical circulation are still insufficiently studied. In this study, we investigated the effects of suprapharmacological concentrations of diazepam in an in vitro model of human umbilical artery (HUA) injury, induced by incubation with 1 mM homocysteine, representing...
Diazepam
Gajić Bojić M, Ritan Mičić Z, Stojmenovski A, Bojanić A, Jovičić S, Matičić M, Mandić-Kovačević N, Uletilović S, Amidžić L, Savić M, Škrbić R•
Background Selenium (Se) and zinc (Zn) are essential micronutrients that play roles in antioxidant defense and the regulation of cell proliferation. Increasing evidence suggests that disturbances in trace element balance may contribute to breast carcinogenesis; however, findings across studies remain inconsistent. Objective To evaluate the association between circulating and tissue Se and Zn levels and breast cancer. Methods A systematic review and meta‐analysis were conducted according to...
Selenium
Lucarelli AP, Martins MM, Teruya MM, Yauti TT, Hayashi DR•
We have previously described the generation of Metal Organic Biohybrids (MOBs) as self-assembling structures that are formed by a combination of a biological component (amino acid), and a metal, such as copper. This MOBs synthesis process has now been distilled to be purely biochemical (a green chemistry process), or abiotic, not requiring the presence of cells. Building on these discoveries, in this commentary we describe the use of selenium for the first time using MOBs synthesis techniques, a...
Selenium
Wells M, Rugg K, Urmee H, Etheridge J, Boudreaux C, Fairley N, DeCoster MA•
Objective(s): The current study aimed to investigate the potential neuroprotective effect of selenium against cognitive dysfunction in rats subjected to chronic intermittent stress. Materials and Methods: Ninety adult male Wistar rats were randomly assigned into five groups (n=18): (1) N: non-stressed group; (2) CS: cold-stressed non-treated group; (3) IS: immobilized-stressed non-treated group; (4) CS/Se: cold-stressed/ selenium-treated group; and (5) IS/Se: immobilized-stressed/selenium-tre...
Selenium
Abdallah MA, Abdel-Razek HAD, Saleh SA, Elseadawy RSA, Kora MA, Younis AG, Salem HR•
Introduction Hashimoto thyroiditis (HT) is an autoimmune disorder that leads to hypothyroidism. Selenium (Se) is essential for thyroid hormone metabolism and immune function, but its role in HT remains debated. This study investigates Se levels in HT patients and evaluates the impact of supplementation on thyroid autoimmunity and thyroid function. Methods This retrospective study analyzed HT patients and healthy controls. Biochemical parameters, including Se, thyroid-stimulating hormone (TSH)...
Introduction This study aims to fabricate dual drug-loaded nanofibrous films made from polyvinyl alcohol (PVA) and chitosan, incorporating cefadroxil and mupirocin to meet the critical needs of burn wound care. Methods Electrospinning was utilized to fabricate cefadroxil- and mupirocin-loaded polyvinyl alcohol PVA/Chitosan nanofibers. Characterization of structural and morphological properties of these nanofibers was done through Fourier Transform IR Spectroscopy, Scanning Electron Microscopy...
Cefadroxil
Rashid S, Ijaz M, Rafique S, Yasin H, Mushtaq M, Khan AK, Khan M, Nasir B, Murtaza G•
Aim To map RN workload, staffing indicators, resident outcomes, workforce sustainability and nursing‐management context in nursing homes. Background Staffing ratios and hours per resident day (HPRD) quantify staffing but not role complexity, interruptions, supervisory demands, resident acuity, continuity or work environment. Evaluation Following JBI guidance and PRISMA‐ScR, five databases were searched using an RN‐specific strategy and updated on 4 September 2026. Following source‐level eli...
Registered Nurse
Almazan J, Zhakupova A, Baimagambet Z, Nurmukhambetova N, Montegrico J, Bolla S, Adolfo CS•
Background Optometrists play a pivotal role in preventing and managing vision impairment through the provision of comprehensive eye care services. In India, vision impairment remains a major public health challenge, largely driven by uncorrected refractive errors, cataract, and other avoidable causes. Despite recent regulatory advances, limited evidence exists on the scope and distribution of specialty optometry practices across Indian states. This study assessed the extent and composition of s...
Background Advanced Nursing Practice is well established in Irish healthcare; these nurses are educated to practice at higher levels of competency as Advanced Nurse Practitioners (ANPs). Nurses working as ANP Older Persons are relatively new and offer a unique skillset that facilitates the delivery of holistic person‐centred care. To date, this represents novel research, as the ANP role in Older Persons’ care has not previously been explored from the perspective of the interdisciplinary team....
Nurse Practitioner
Mullally A, Doolan M, Brennan C, Burke L, Farrelly A, Flynn G, Heduvan K, Keena G, Lynch O, Mannion J, Moore F, Nolan M, McDonnell-Naughton M•
Background Telehealth can increase access to medical and allied health services in residential aged care facilities (RACFs). Objectives This study investigated the feasibility of a telehealth collaborative care model involving on‐site nurse practitioner and off‐site clinical pharmacist to simplify complex medication regimens in RACFs. Methods This was a pragmatic, nonrandomized pilot and feasibility study in three Western Australian RACFs. A nurse practitioner and an off‐site clinical pharm...
Nurse Practitioner
Ooi CE, Martini A, Walton R, McInerney B, Troeung L, Bell JS•
Resumen Antecedentes: La cardiología nuclear integra medicina nuclear y cardiología para mejorar el diagnóstico, la estratificación y el manejo de enfermedades cardiovasculares. El desarrollo continuo de estas técnicas y su creciente aplicación clínica requieren protocolos estandarizados basados en evidencia para optimizar su uso. Por ello, es fundamental elaborar consensos que garanticen una utilización adecuada de la imagen en beneficio de los pacientes. Objetivo: Desarrollar recomendacion...
Cardiology
Vidal M, Gallego C, Roncancio G, Angarita E, Cárdenas R, Dueñas K, García JC, González G, Granados U, Londoño JL, León JDL, López N, Marín V, Martínez É, Murgueitio R, Mejía A, Rodríguez MJ, Silva E, Uribe LG•
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