Clinical intelligence & editorial.

PubMed

Clopidogrel-Induced Insulin Autoimmune Syndrome: Efficacy of Glucocorticoid Therapy and Continuous Glucose Monitoring.

Introduction Insulin autoimmune syndrome (IAS) is a rare cause of spontaneous hyperinsulinemic hypoglycemia characterized by elevated insulin autoantibody (IAA). Over half of IAS cases involve exposure to sulfhydryl group-containing medications or their active metabolites, with clopidogrel being an uncommon trigger. We report a case of clopidogrel-induced IAS (CIAS) treated with glucocorticoid and managed by continuous glucose monitoring (CGM) during follow-up. Case Report A 77-year-old man d...

Glucose Monitoring

Luo L, Xiong X, Ran J• January 1, 2026

PubMed

Continuous Interstitial Glucose Monitoring through a Long-Term Subcutaneous Implantable Sensor during Pregnancy in Type 1 Diabetes: A Two- Patient Case Report.

Introduction Optimal glycaemic control is crucial during pregnancy in women with type 1 diabetes mellitus (T1D). Current guidelines, based on positive data from the CONCEPTT (Continuous Glucose Monitoring in Pregnant Women With Type 1 Diabetes Trial), on maternal glycaemic control and fetal outcomes, recommend offering real-time Continuous Glucose Monitoring (rt-CGM) as a standard method in all pregnancies of women with type 1 diabetes (T1D). Case Presentation In these two clinical cases, we...

Glucose Monitoring

Nazarena B, Veronica R, Alessia G, Antea C, Federica M, Walter V, Emanuela O, Carlo BA• January 1, 2026

PubMed

Hybrid Deep Learning Framework for Continuous Blood Glucose Monitoring and Gestational Diabetes Risk Prediction.

Gestational diabetes mellitus (GDM) affects almost 10%-12% of pregnancies worldwide, threatening maternal and fetal life. Continuous glucose monitoring (CGM) forms the backbone of managing GDM, and the current methodologies largely disregard physiological and behavioral factors, thereby greatly reducing accuracy and clinical interpretability. Methods A hybrid deep learning framework was developed by fusing CGM with multi-sensing modality data, including heart rate, activity levels, sleep patte...

Glucose Monitoring

Chanumolu KK, Nagamani GM, Hemalatha GM• January 1, 2026

PubMed

Machine Learning and ECG-Derived Biomarkers for Objective Pain Assessment: An Explainable AI Approach Toward Precision Pain Management.

Background Pain assessment disparities across demographic groups pose a significant healthcare challenge, with women, elderly patients, and racial minorities frequently experiencing inadequate treatment. Current pain evaluation relies predominantly on subjective self‐reporting scales, which lack objective physiological biomarkers and can be influenced by communication barriers and provider bias, limiting their effectiveness for equitable and precise pain measurement. Objectives This study inv...

Ecg

Sabbadini R, Italiano GF• January 1, 2026

PubMed

Remote ECG monitoring as a diagnostic tool for therapeutic strategies after transcatheter aortic valve replacement: rationale and design of the DRAGON-TAVI randomized trial.

Background Severe aortic valve stenosis (AS) is the most common valvular heart disease, and the aging population causes the prevalence of AS to increase each decade [1, 2]. Transcatheter aortic valve implantation (TAVI) is an emerging therapeutic approach for patients with this condition, primarily for those at high surgical risk, but it is increasingly used in a broader group of patients with AS [3, 4]. The TAVI procedure carries a risk of serious complications, such as stroke, life-threateni...

Ecg

Lis P, Koźlik M, Chamera M, Kułach A, Smolka G, Smolarek M, Orszulak M, Mizia-Stec K, Szydło K, Gołba K, Gładysz-Wańha S, Kuźma Ł, Morkisz Ł, Gocoł R, Hudziak D, D'Ascenzo F, de Ferrari GM, Lip GYH, Wojakowski W, Wita K, Wańha W• January 1, 2026

PubMed

Assessing ECG Findings in Pediatric COVID-19 Patients: A Comprehensive Analysis.

Introduction COVID-19 can be associated with varying degrees of cardiac involvement in children, such that myocardial damage can be caused directly by the COVID-19 virus itself or systemic inflammation caused by the infection. The present study was conducted with the aim of evaluating ECG findings in children with COVID-19. Methods This is a prospective cross-sectional study that was conducted by census method on 764 children with COVID-19 in hospitals related to Mashhad University of Medical...

Ecg

Naghibi M, Ghiasi SS, Raesi R, Rahimpour F• January 1, 2026

PubMed

Exploring the Impact of Extended Amino Acid Supplementation on Body Composition and Psychopathology in Patients with Eating Disorders Undergoing Psycho-Nutritional Rehabilitation.

Background Eating disorders are frequently linked to protein-energy malnutrition, resulting from chronic energy intake reduction, and leading to reduced body weight and altered body composition. A nutritional approach based on the supplementation with a mixture of essential amino acids has proven effective in conditions characterized by reduced dietary intake and increased degradation of endogenous proteins and might also contribute to correct the amino acid deficiency possibly involved in the...

Body Composition

Napolillo M, Ragione LD, De Iaco G, Mococci T, Sacco R, Marucci S• January 1, 2026

PubMed

Blood Pressure Management in Dialysis: A Comparative Review of Hemodialysis and Peritoneal Dialysis.

Hypertension is a major challenge in patients with end-stage kidney disease (ESKD) undergoing dialysis, contributing to increased cardiovascular morbidity and mortality. Both hemodialysis (HD) and peritoneal dialysis (PD) serve as renal replacement therapies, yet their effectiveness in blood pressure (BP) control remains a subject of ongoing debate. Emerging evidence suggests that PD may offer better BP regulation than HD due to continuous ultrafiltration, superior sodium removal, and the preser...

Blood Pressure

Jonny J, Pranidya NP, Sugiharta AJ• January 1, 2026

PubMed

Early-Life Predictors of Obesity and High Blood Pressure Comorbidity at Midlife: Findings From the 1958 National Child Development Study (NCDS).

Background Early‐life exposures can increase the risk of both obesity and high blood pressure in adulthood. In this paper, we identify exposures across five pre‐hypothesised childhood domains, explore them as predictors of obesity and high blood pressure comorbidity using the 1958 National Child Development Study (NCDS), and discuss these results in comparison to a similar approach using another birth cohort (1970 British Cohort Study (BCS70)). Methods The analytical sample included 9150 part...

Blood Pressure

Stannard S, Owen RK, Berrington A, Ziauddeen N, Fraser SDS, Paranjothy S, Hoyle RJ, Alwan NA• January 1, 2026

PubMed

Geographic variation in proportions meeting the waist circumference criterion and having elevated hemoglobin A1c among Specific Health Checkup examinees in Japan: an ecological analysis of the 10th NDB Open Data.

Background Publicly available aggregate health data can support regional surveillance of cardiometabolic risk, but analyses must address aggregation, ecological inference, and cell suppression or unavailability. Waist circumference and body mass index (BMI) capture related but distinct aspects of adiposity. We evaluated the usefulness and limitations of selected 10th National Database (NDB) Open Data indicators for prefecture-level cardiometabolic surveillance among Specific Health Checkup exam...

A1c

Nakashima H, Kamihara T, Omura T• January 1, 2026

PubMed

Effectiveness of Individualized Nursing in Perioperative Management of Patients With Obstructive Sleep Apnea: A Retrospective Cohort Study.

Background Patients with obstructive sleep apnea (OSA) are at increased risk of perioperative complications, such as hypoxemia, respiratory depression, and airway obstruction. This study aims to evaluate the effectiveness of individualized nursing in the perioperative management of patients with OSA. Methods We retrospectively analyzed 107 patients with OSA undergoing elective surgery between January 2023 and January 2025, who were allocated to a conventional group (n = 55) or an individualiz...

Sleep Apnea

Lin Q, Yang Y, Huang C, Huang D, Fang C• January 1, 2026

PubMed

SDANN May Be Used as a Screening Factor of Obstructive Sleep Apnea in Adult Individuals.

Background Obstructive sleep apnea (OSA) is a common disease and can be diagnosed with polysomnography (PSG). However, it is limited and has a long waiting time. This study is aimed at evaluating if HRV can be a screening tool for OSA in a real‐world setting. Methods This was a prospective study that enrolled adult patients aged 18 years or older who were suspected of OSA and underwent both PSG and HRV tests. A stepwise multivariable logistic regression analysis was executed to identify predi...

Sleep Apnea

Sonsuwan N, Charoenwaree C, Chattipakorn N, Sawanyawisuth K• January 1, 2026