Clinical intelligence & editorial.

PubMed

Artificial intelligence in allergology: A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI), German Academy of Allergy, Clinical Immunology and Environmental Medicine (AeDA) and German Society of Pediatric Allergology and Environmental Medicine (GPA): Part 2.

Background: Although artificial intelligence (AI) is advancing in medicine, its use in allergology remains limited. Because allergic diseases are heterogeneous and clinical, environmental, and molecular data are difficult to integrate, assessment is needed. This second part of a position paper by German allergology societies and associations, led by the German Society of Allergy and Clinical Immunology (DGAKI), establishes a framework for AI in allergology. Materials and methods: The position pa...

Allergy

Pfaar O, Traidl S, Bärhold F, Becker S, Bergmann C, Buters J, Dramburg S, Francuzik W, Gerstlauer M, Hamelmann E, Hernandez Toro CJ, Klimek L, Lange L, Matricardi PM, Pfeffer L, Suarez-Suarez M, Utz P, Wagenmann M, Worm M, Yoosefi M, Mathes S, Seurig S• November 5, 2026

PLOS

A computational framework to model cartilage degeneration induced by mechanoinflammation and cytokine-driven inflammation in post-traumatic osteoarthritis

Knee joint injury is a major risk factor for post-traumatic osteoarthritis (PTOA), often associated with early cartilage degeneration. Mechanical overloading and cytokine-driven inflammation are key drivers of this process, yet the underlying mechanisms and their distinct temporal and spatial contributions to cartilage degradation remain unclear. Here, we present a mechanobiological finite element framework that simulates cartilage degradation through cell-mediated proteolytic activity triggered...

Osteoarthritis

Moustafa Hamada, Atte S. A. Eskelinen, Joonas P. Kosonen, Sanna Hakonen, Cristina Florea, Alan J. Grodzinsky, Rami K. Korhonen, Petri Tanska• November 5, 2026

PLOS

Clinical supervision in public hospitals in Lesotho: Nurse managers’ support for registered nurses

Background: Clinical supervision is regarded as essential for nurse managers in diverse healthcare settings to enhance nurse satisfaction, competence, and retention, leading to improved nursing care quality. The study aimed to explore and describe nurse managers’ support provided to registered nurses during clinical supervision at public hospitals in Lesotho. Methods: The study employed an exploratory descriptive qualitative research design to explore and describe the support provided to registe...

Registered Nurse

Mpho Zakaria Shelile, Molekodi Jacob Matsipane, Seepaneng Salaminah Moloko-Phiri, Miriam Mmamphamo Moagi• November 5, 2026

PLOS

Correction: Multiplex PCR assay to detect high risk lineages of Salmonella Typhi and Paratyphi A

Following the publication of this article [ 1 ], concerns were raised regarding Figs 2 and 3. Specifically, Figs 2 and 3 do not appear to match their corresponding captions. The second author stated that Figs 2 and 3 appear in the incorrect order in [ 1 ], that the gel image in Fig 2 in [ 1 ] should be Fig 3, and that the primer sequences in Fig 3 in [ 1 ] should be Fig 2. Please see the corrected figures below. The first author also stated that the gel image in Fig 2 in [ 1 ] is incorrect. Th...

Pcr

Fahad Khokhar, Derek Pickard, Zoe Dyson, Junaid Iqbal, Agila Pragasam, Jobin Jacob John, Balaji Veeraraghavan, Farah Qamar, Gordon Dougan, Hilary MacQueen, Sushila Rigas, Mark Holmes, Ankur Mutreja• November 5, 2026

PLOS

Inactivation of microorganisms in the complex regions of transvaginal ultrasound probes by a UVC-LED light based disinfection system

Endocavity ultrasound transducers, particularly transvaginal ultrasound (TVUS) probes, contain intricate structures such as notches, grooves, lens surfaces, and handle edges that are highly susceptible to microbial contamination yet difficult to disinfect using conventional high-level disinfection (HLD) methods. This study evaluated the efficacy of a novel ultraviolet C light emitting diode (UVC-LED) HLD system in eliminating microbial contamination from these complex probe surfaces. Two TVUS pr...

Ultrasound

Muhammad Yasir, Mark D. P. Willcox• November 5, 2026

PLOS

Initial failure morphology of shallow loess containing millimeter-scale cracks: Insights from CT 3d imaging

Frequent shallow loess slope failures in loess regions pose significant threats to both linear infrastructure and local communities. Millimeter-scale initial cracks induced by water, temperature, and weathering are key factors controlling such loess failures. Early diagnosis and prevention remain challenging, largely because the disaster chain triggered by millimeter-scale initial cracks is not fully understood, and the early failure behavior of these cracks is poorly characterized. In this stud...

Scales

Luqing Zhao, Cuiying Zhou, Zhen Liu, Qingyi Mu, Penghui Ma, Jianbing Peng• November 5, 2026

PLOS

Development of shelf-stable reagents and assay kits for bioluminescence applications using the capillary-assisted vitrification platform stabilization technology

Luminescence is a powerful method for detecting trace analytes and monitoring biological processes. However, most bioluminescence reagents, including luciferase and its substrates, are sensitive to temperature, limiting their usable shelf lives, and resulting in inconsistent performance. Enhancing the stability of these reagents could reduce signal variability between experiments, simplify workflows, and address cold chain storage issues. In this study, we demonstrate the application of the plat...

Reagents

Shari Radford, Yolanda Peris-Taverner, Michael Dibble, Kevin Corn, Tian Zhu, Shannon Martello, McKenzie Mayeaux, Amanda Ladd, Sankar Renu, Tejasvi Chunduri, Aniket Jadhav, Melanie Dart, Marjan Rafat, Mary Shank-Retzlaff, Laura L. Bronsart• November 5, 2026

PLOS

Microscopic risk assessment of highway weaving sections based on large-scale UAV trajectory data: What kinematic and interaction measures each detect

Microscopic risk assessment of highway weaving sections relies largely on single-vehicle kinematic indicators, yet what such indicators actually detect is rarely tested against a measure of vehicle-to-vehicle interaction. This study analyses 12,256 complete vehicle trajectories collected by UAV at seven highway weaving sections, and evaluates every trajectory along two independent dimensions: a kinematics-based composite indicator combining longitudinal acceleration, lateral acceleration and lon...

Microscopes

Zhenghua Huang, Zhibing Yuan, Mengyuan Wang, Peng Fu• November 5, 2026

PLOS

Unveiling the functional landscape of A-to-I RNA editing associated with Marek’s disease in chickens

Genetic improvement of disease resistance against viral infections represents a longstanding and formidable challenge in animal breeding. The antiviral innate immune response is highly regulated at the RNA level, especially through RNA modifications. Adenosine-to-Inosine (A-to-I) RNA editing modifies the mRNA sequence. Growing evidence shows that this type of RNA editing plays a key role in mediating cellular responses to viral infections and disease resistance. However, the role of RNA editing...

Aed

Qunhao Niu, Yi Ding, Longbin Yang, John R. Dunn, Huanmin Zhang, Keji Zhao, Jiuzhou Song• November 5, 2026

PLOS

Differential changes in cervical proprioception and motor imagery following structured imagery training in chronic neck pain

Background: Chronic neck pain (CNP) is associated with altered sensorimotor function, including impairments in cervical proprioception and changes in body-related perception. While implicit motor imagery (IMI)–based interventions have shown clinical benefits, their effects on cervical proprioceptive performance and motor imagery-related outcomes in individuals with CNP remain unclear. Objective: To investigate the effects of lateralization and IMI training on cervical proprioception (CP), neck a...

Pain

Aysegul Bostan, Aysenur Akan, Ozlem Ulger• November 5, 2026

PLOS

Supporting engagement, behavior change, and equitable self-management in menstrual and menopausal health: A multi-agent digital-health framework

Menstrual-cycle–related conditions and, later, menopausal symptoms are highly prevalent across the female life course and impose a large, under-recognized burden on quality of life and work, yet digital tools to support self-management are fragmented, hard to sustain, and unevenly reached. We propose HERA (Health Engagement and Reflective Agent architecture), a conceptual, hypothesis-generating framework for supporting engagement, behavior change, and equitable self-management in menstrual and m...

Menopause

Koichiro Yuji, Wakako Yuji, Maika Nariai, Yuki Enomoto, Osamu Wada-Hiraike• November 5, 2026

PLOS

Effectiveness of nurse-led hypertension interventions on retention, adherence, and blood pressure control among adults in low- and middle-income countries: A systematic review

Background: Hypertension affects more than 1.28 billion adults globally and remains the leading modifiable risk factor for cardiovascular disease, stroke, renal failure, and premature death. This burden is inconsistently distributed across Low- and Middle-Income Countries (LMICs), where nearly three-quarters of adults live with hypertension. This gap is largely driven by poor adherence and low retention. This systematic review aims to assess the effectiveness of nurse-led interventions on retent...

Blood Pressure

Tagese Yakob, Charuai Suwanbamrung, Cua Ngoc Le, Abebe Sorsa Badacho, Udomsak Saengow• November 5, 2026