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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 13–24 of 1,604 articles

PubMed

Network changes in psychopathological symptoms following cognitive behavioral therapy for social anxiety disorder: evidence from 29 university outpatient clinics.

While network theory posits that interactions between social anxiety symptoms perpetuate social anxiety disorder (SAD), findings on how these networks change following treatment remain inconsistent. This study used data from 29 university outpatient clinics in Germany to estimate psychopathological symptom networks for patients with SAD at pre-treatment, explore critical symptoms and connections in pre- and post-treatment networks, and identify network changes in remitted vs. non-remitted patien...

Anxiety
Wen X, Velten J, Christiansen H, Hoyer J, In-Albon T, Lincoln TM, Lutz W, Rubel JA, Schwartz B, Stark R, Werheid K, Willutzki U, Bartholdy S, Berger EM, Bräscher AK, Forkmann T, Glombiewski JA, Hehlmann M, Helbig-Lang S, Hermann A, Hermann C, Kirsch A, Klucken T, Lueken U, Michael T, Odyniec P, Pedersen A, Pittig A, Renneberg B, Risch AK, Rudolph A, Scholten S, Schweden T, Teismann T, Vehlen A, Wilz G, Margraf J•
PubMed

Conceptualizing the process of experiential acceptance during an episode of anxiety: A qualitative study of individuals with prior experience in mindfulness- and acceptance-based interventions.

Introduction Experiential acceptance refers to the capacity to be open to internal experiences without attempting to change or avoid them. Although acceptance is a core emotion regulation strategy within mindfulness- and acceptance-based interventions (MABIs) and a protective factor for mental health, its conceptualization and implementation remain unclear and ambiguous. The aim of this study was to clarify and develop a model of accepting anxiety as experienced by individuals with prior experi...

Anxiety
Ribeyron J, Duriez N, Shankland R•
PubMed

Mathematical modeling and optimal control of immune responses in multiple sclerosis.

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by immune-mediated destruction of the myelin sheath in the central nervous system. In this work, we develop and analyze a mathematical model describing the interactions among myelin, autoreactive immune cells, regulatory immune cells, and treatment. A fast-time reduction of the slow–fast model yields an analytically tractable immune subsystem that captures the principal immune interactions. We establish the existence and stabi...

Multiple Sclerosis
Al-arydah M•
PubMed

Retraction: Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone –induced multiple sclerosis model.

Following the publication of this article [1], the corresponding author requested a correction to Fig 6C and 6D, after concerns were raised about unusually repetitive features appearing in these panels. The corresponding author stated that internal microscope-generated labels were removed from the Fig 6C and 6D image by covering the labelled areas with a portion of the adjacent image. They provided what they described as an original unedited image underlying Fig 6D, and a re-stained and reimaged...

Multiple Sclerosis
The PLOS One Editors•
PubMed

The hematology workforce in the United States: past, present, and strategies for the future.

Abstract From 2017 to 2021, the American Society of Hematology (ASH) conducted the largest study to date of the hematology workforce in the United States. The study highlighted a deficit in the classical hematology (CH) workforce. Despite the very high CH clinical volumes encountered by practicing hematologists and medical oncologists, <5% of all hematology and medical oncology fellows reported having a career focus in CH. The reason underlying this deficit was a lack of mentorship in CH compar...

Hematology
Lee AI, Masselink LE, Naik RP, Carraway H, Connell NT, DeCastro LM, Dent GA, DiMichele D, Ellis L, Leon AG, Loren AW, Lucas TL, Marshall AL, Mims M, Nelson M, Nagalla S, O'Connell C, Park SJ, Rajasekhar A, Sharma D, Smith M, Weeks LD, Wun T, Fritz J, Reynolds R, Van Havre N, Erikson CE•
PubMed

American Society of Hematology 2026 guidelines for diagnosis of iron deficiency.

Background Iron deficiency is the most common micronutrient deficiency and, when untreated, progresses to anemia. Existing guidance on the diagnostic criteria for iron deficiency is limited and not evidence based. Objective These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in their decisions about the diagnosis of iron deficiency, taking a global perspective in all settings. Methods A...

Hematology
Powers JM, Lim MY, Achebe MO, Akpan IJ, Auerbach M, Brown MC, Cardenas MP, Cromwell C, DeLoughery T, Fleming RE, Fraga M, Goshua G, James P, Lewkowitz A, May J, Nnadozie G, Ogunnaya F, Ruiz-Arguelles GJ, Sholzberg M, Van Doren L, Weyand AC, Zeller MP, Azzam M, Choaib A, Hamarsha Q, Kawtharany H, Khawandi J, Mustafa RA•
PubMed

Machine learning prediction of the change in sleepiness following continuous positive airway pressure in obstructive sleep apnea: a multi-cohort analysis.

Abstract Study Objectives To predict the improvement in sleepiness following continuous positive airway pressure treatment for obstructive sleep apnea using baseline characteristics. Materials and Methods Data from five polysomnography cohorts (HomePAP, BestAIR, ABC, STAGES, and MESA; total n = 2332) were analyzed. Associations between polysomnographic metrics and Epworth Sleepiness Scale were assessed using multivariable linear regression. Cross-validated Least Absolute Shrinkage and Select...

Sleep Apnea
Staykov E, Töyräs J, Mann DL, Leppänen T, Kainulainen S, Azarbarzin A, Sands SA, Terrill PI•
PubMed

Cardiovascular outcomes of glucagon-like peptide-1 receptor agonists: A systematic review.

Abstract Purpose To identify and evaluate cardiovascular outcome trials for glucagon-like peptide-1 receptor agonists (GLP1RAs) in various patient populations, including those with or without type 2 diabetes (T2D). Summary A systematic search of MEDLINE identified 12 cardiovascular outcome-based randomized controlled trials: 10 in patients with T2D, one in patients with overweight/obesity and atherosclerotic cardiovascular disease (ASCVD) but not T2D, and one in patients with obesity and hea...

Cardiovascular
Bihelek N, Burke S, Barry AR•
PubMed

Effectiveness of guided internet-delivered cognitive behavioral therapy for insomnia in autistic adults (i-Sleep Autism): a randomized controlled trial.

Abstract An estimated 60% of autistic adults suffer from insomnia symptoms, which significantly impairs daily functioning and wellbeing. This study evaluated the effectiveness of i-Sleep Autism, a 5-week, guided self-help internet-delivered cognitive behavioral therapy-based intervention (ICBT-I) for insomnia in autistic adults. In co-creation with seven autistic adults with sleeping problems, i-Sleep Autism was adapted from i-Sleep, a pre-existing non-autism specific intervention. A total of 1...

Autism
Spaargaren KL, Begeer S, Nieuwenhuis S, Bradley J, Riper H, Greaves-Lord K, van Straten A•
PubMed

Real-world hospital pharmacy and nursing study assessing the time and motion comparison of 3 different marketed formulations of a cephalosporin antibiotic.

Abstract Purpose To assess the comprehensive workflow and time and motion activities associated with hospital pharmacy and nursing staff for a cephalosporin antibiotic in 3 different marketed formulations: (1) a formulation prepared by traditional compounding, (2) a dual-chamber IV bag stored with prefilled diluent in the upper chamber and powdered drug in the lower chamber, and (3) a standard diluent container with an integrated drug vial adaptor that allows for drug admixture after connectio...

Antibiotic
Patel AN, Curtin CR, Ortiz K, Valencia D, Martin R, Runge M, Wicks J•
PubMed

Maternal oncostatin M levels in gestational diabetes mellitus: associations with metabolic dysfunction and pregnancy outcomes.

SUMMARY OBJECTIVE: Gestational diabetes mellitus is characterized by metabolic dysfunction and altered inflammatory signaling. The aim of this study was to evaluate maternal serum oncostatin M levels in pregnancies complicated by gestational diabetes mellitus and explore their associations with metabolic and pregnancy outcomes. METHODS: In this prospective case–control study, 40 women with gestational diabetes mellitus and 40 healthy pregnant controls were enrolled. Maternal serum oncostatin...

Pregnancy
Kapudere B, Akdemir Y, Guven B•

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