Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Abstract Conditioned pain modulation (CPM) assesses descending pain inhibition in humans and has been shown to be clinically relevant. However, the possible contribution of the CPM response to the efficacy of local anesthetics remains poorly understood. This study aimed to evaluate the association between the CPM response and the efficacy of topical anesthesia applied to the trigeminal region in females with chronic orofacial pain and healthy participants. Thirty-five females with painful tempo...
Pain
LORENZO IA, CUNHA LDLL, NASCIMENTO AMDS, MONTEIRO RDC, BONJARDIM LR, COSTA YM•
ABSTRACT Objective: To evaluate, in children and adolescents with asthma, the effects of an 8-week exercise training program on exercise capacity. Methods: Single-blind, randomized clinical trial in participants with asthma between six and 17 years old under regular treatment. The intervention group performed supervised aerobic and resistance training, and the control group performed supervised stretching in 60-minute sessions twice a week for eight weeks. They were assessed at baseline and...
Asthma
Reimberg MM, Scalco RS, Salu BR, Serra AJ, Wandalsen GF, Solé D, Corso SD, Lanza FDC•
Following publication of [ 1 ], the corresponding author ZW contacted PLOS requesting retraction of their article due to errors in the methodology and difficulty reproducing the data. During editorial follow-up, it was also determined that this article contains a substantial degree of overlap with a previously published article [ 2 ] with regard to the reported abstract, Figs 1-2, and Tables 1-6. An editorial assessment by PLOS has established that the extent of the overlap is such that this ar...
Parkinson's disease (PD) in pregnancy is rare, and there are no agreed guidelines for its management. We report a 34-year-old primigravida with a three-year history of young-onset PD who presented at eight weeks' gestation with an unplanned pregnancy. She had previously tolerated levodopa poorly, with nausea and early peak-dose dyskinesia, and before conception her symptoms were reasonably controlled on amantadine, selegiline and procyclidine. Because of the potential teratogenicity of amantadin...
Background Psoriasis remains a therapeutic challenge, demanding safer, more effective, and cost-efficient treatment modalities. This study evaluated the therapeutic potential and underlying mechanisms of Dynamic Permanent Magnetic Field (DPMF) intervention alone and in combination with calcipotriol in an imiquimod (IMQ)-induced mouse model of psoriasis. Methods Sixty-six male BALB/c mice were randomized into seven groups (n = 8–10/group). Following daily IMQ application, intervention groups r...
Psoriasis
Lai D, Tian Y, He S, Wang W, He Y, Wang H, Liu S, Cheng S•
Abstract Management of Zollinger–Ellison syndrome (ZES) in patients with multiple endocrine neoplasia type 1 (MEN1) remains controversial, particularly in non‐metastatic disease where the role of surgery is debated. In contrast, treatment of metastatic disease is guided by established systemic approaches. We aimed to evaluate stage‐dependent clinical decision‐making in MEN1‐related ZES using standardized clinical vignettes across ENETS Centers of Excellence (CoEs). A questionnaire‐based study u...
Zollinger-Ellison Syndrome
Daskalakis K, Pieterman CRC, Bartsch DK, Manoharan J, Grozinsky‐Glasberg S, Howe JR, Andreassen M, Begum N, O'Toole D, Denecke T, Faggiano A, Falconi M, Partelli S, Pascher A, Welin S, van Dijkum EN, Munir A, Perren A, Massironi S, Santos AP, Tirosh A, Milanetto AC, Modica R, Stefańska A, Kloeppel G, Ferolla P, Valk GD, Kaltsas G•
Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammatory involvement and an unpredictable clinical course. SLE is among the most prevalent autoimmune diseases in Morocco, yet epidemiological and clinical data from this region remain limited. Disease management relies mainly on conventional therapies, with restricted access to advanced targeted treatments. Objective To describe the epidemiological, clinical, biological, and thera...
ABSTRACT Background Minor ailments account for a substantial proportion of demands in community pharmacies, particularly in contexts marked by high self‐medication and risk of inappropriate medication use. Objective To evaluate the adherence of pharmacological and non‐pharmacological interventions to clinical guidelines for minor ailment management and to analyze patient‐reported clinical outcomes. Methods This observational, quantitative, descriptive study analyzed 227 pharmacist consulta...
Abstract Background Despite the increasing use of liver contrast-enhanced ultrasound (CEUS), no standardized, organ-specific tool exists for assessing trainees’ cognitive competency. Existing instruments lack multidimensional evaluation and external validation, which limit training quality and patient safety. Objective This study aims to develop and validate the CEUS Competency Assessment for the Liver (CCAL), a tool to standardize the evaluation of theoretical and cognitive skills in liver...
Ultrasound
Ma Y, Zheng B, Ren J, He W, Shang L, Wang H, Xue G, Nie F, Guo Y, Luo Y, Zhang H, Wang X, Jing X, Zhang R, Yuan J, Wu R, Luo X, Dong F, Luo Y, Lu Q, Liao J, Huang P, Chen Q, Zhu J, Xu Y, Xie X•
Abstract Introduction Only 60% of patients with acute ischemic stroke (AIS) achieve successful reperfusion after the first endovascular thrombectomy (EVT) attempt. In vitro studies have shown that thrombus stiffness influences thrombus-device interaction and retrieval efficacy. This prospective observational study investigates how thrombus stiffness relates to clinical factors, thrombus imaging characteristics and histological composition. It further explores the association between thrombus s...
Stroke
Bontempi L, Cruts JMH, Cahalane RME, Ilie OE, Boodt N, Bos D, Fereidoonnezhad B, van Doormaal PJ, van der Lugt A, Dippel DWJ, Gijsen FJH•
Ticagrelor is a reversible P2Y12 receptor antagonist used for antiplatelet therapy and is well recognized to cause dyspnea. Emerging concern has focused on a possible association between ticagrelor and central sleep apnea, Cheyne-Stokes respiration, and other manifestations of ventilatory instability. This narrative review examines the clinical evidence for ticagrelor-associated central sleep apnea and the respiratory-control mechanisms proposed to underlie this association. A structured literat...
Sleep Apnea
Pham B•
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