Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Background: Serial ultrasound measurements may help characterize muscle wasting in critically ill patients. The flexor carpi ulnaris (FCU) is a superficial forearm muscle that may provide an additional assessment site. We described longitudinal FCU and biceps brachii (BB) cross-sectional area (CSA) changes and explored between-muscle differences and clinical associations. Methods: This prospective two-center observational study enrolled 23 intensive care unit (ICU) patients; 20 were included in...
Ischemic heart disease remains the leading cause of mortality worldwide. Its diagnosis largely relies on detecting dynamic changes in the ST segment of the electrocardiogram (ECG). However, alterations in other ECG waves and intervals have also been reported. One factor that is often overlooked is the presence of a prior myocardial infarction and its influence on the myocardial response to a new ischemic event. This study aimed to quantify the magnitude and temporal dynamics of ECG changes durin...
Ecg
Jimena Rodríguez-Carbó, Ana Mincholé, Esther Pueyo•
Following the publication of this article, the corresponding author made PLOS aware that the Ethics statement in the Methods section of [ 1 ] is incorrect and that the work reported in [ 1 ] was not supported by a valid protocol approval. A representative of Merrimack College stated that a valid Institutional Animal Care and Use Committee (IACUC) approved protocol covering the experiments in [ 1 ] does not exist, that approval from an external IACUC was not sought, and therefore that the Ethics...
Background: Post‑stroke fatigue (PSF) affects approximately 50% of stroke survivors and is one of the most common and disabling post‑stroke sequelae. Digital and technology‑enabled approaches have attracted increasing attention in the field of stroke rehabilitation, including mobile health applications (mHealth), wearable devices, virtual reality (VR), remote rehabilitation, artificial intelligence (AI), and neuromodulation technologies. However, no comprehensive scoping review has systematicall...
Photophobia encompasses a continuum of light-induced experiences from mild discomfort to overt pain and intolerance, yet clinical tools rarely quantify these distinctions, leaving many patients undiagnosed and untreated. This study employed the Ocular Photosensitivity Analyzer (OPA), a compact instrument for quantitative sensory testing (QST) with light, to investigate three perceptual levels in healthy adults: visual photosensitivity discomfort threshold (VPDT), visual photosensitivity pain thr...
Pain
Nathan Goturi, Cameron Talbert, Nicholas Pondelis, Mariela C. Aguilar, Alex Gonzalez, Cornelis Rowaan, Heather Durkee, Jean-Marie Parel, Vanda Faria, Eric Alan Moulton•
Breast cancer (BC) represents the most prevalent malignant tumor among women globally, with its pronounced heterogeneity presenting significant challenges for precision diagnosis and treatment. Aberrant lipid metabolism, particularly the ratio of low-density lipoprotein to high-density lipoprotein (LHR), has garnered considerable interest in relation to BC development and progression. Nevertheless, the association between LHR and clinicopathological characteristics remains inadequately explored....
Menopause
Lei Dong, Can Liu, Lixin Li, Xiaotong Zhang, Wei Xu, Gaosai Dai•
Attention deficit hyperactivity disorder (ADHD) is associated with various traits that influence individuals’ experiences at work. While some may be experienced as challenging (e.g., when differences in executive function impact time management), others can be more positive (e.g., when curiosity motivates exploration and discovery). Plausibly, academia is a work environment where these positive aspects should be valued. However, ADHD is still often viewed from a medicalised perspective in workpl...
Adhd
Lorna G. Hamilton, Anusha V. Ramji, Mahmoud Elsherif, Steven K. Kapp, Justin Sulik•
Paxlovid (nirmatrelvir/ritonavir) has been approved for use in patients who are at high risk for severe acute COVID-19 illness. Evidence regarding whether acute use of Paxlovid protects against Post-Acute Sequelae of SARS-CoV-2 infection (PASC), or Long COVID, is mixed in high-risk patients and lacking in low-risk patients. With a target trial emulation framework, we evaluated the association of Paxlovid treatment within 5 days of SARS-CoV-2 infection with incident Long COVID and hospitalization...
Paxlovid
Chengxi Zang, Haoyang Li, Dhruv Khullar, Yongkang Zhang, Stephenson Strobel, Yong Chen, Marc A. Sala, Payal Bharat Patel, Alejandro P. Comellas, Andrew Wylam, Mark Weiner, Chris B. Forrest, Thomas Carton, Fei Wang, Rainu Kaushal, on behalf of the RECOVER Consortium•
Background: Nutrition plays a crucial role in oral health, influencing the risk of caries, periodontal disease, erosion, and oral cancers. Dentists are key providers of dietary guidance, but require adequate knowledge to do this effectively. This study compared the impact of multimedia versus audio-based educational interventions on the knowledge and self-reported behavior of general dentists in Tehran regarding nutrition and oral health. Methods: In this randomized controlled trial, 166 general...
Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) is a major swine pathogen that causes substantial economic losses worldwide. Defective viral genomes (DVGs) are important regulators of viral replication, persistence, and evolution in many RNA viruses. However, the characteristics and functions of DVGs generated during PRRSV-2 infection remain unknown. Here, we systematically analyzed publicly available high-throughput sequencing datasets and characterized DVGs generated durin...
Diet quality plays an important role in the management of non-communicable diseases, including hypertension. A better understanding of dietary profiles in high-altitude populations with hypertension could help improve the effectiveness of interventions. We aimed to characterize diet quality and its association with blood pressure among adults with hypertension living at high-altitude. Cross-sectional study of baseline data from an ongoing trial in Puno, Peru. We enrolled 154 adults with hyperten...
Blood Pressure
Carla Tarazona-Meza, Mika Matsuzaki, Kendra N. Williams, Laura E. Caulfield, Sabri Bromage, Lucy Cordova-Ascona, Lindsay J. Underhill, Lisa de las Fuentes, Gonzalo M. Cuentas-Canal, Zoila Vela-Clavo, Marilú Chiang, Elvin H. Geng, Victor G. Dávila-Román, Stella M. Hartinger, William Checkley•
Bullying victimization is an important public health concern that has been linked to adverse psychological outcomes among adolescents. The study used mental health well-being data collected in the most recent Bangladesh Adolescent Health and Wellbeing Survey (2019–2020) (BAHWS). A total of 9,116 adolescents aged 15–19 years with complete depression data were included in the analysis. A three-level linear mixed-effects model was employed to account for the hierarchical structure of the survey, wi...
Depression
Ruhul Amin, A S M Rafad Asgar•
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