Clinical intelligence & editorial.

PubMed

Development, validation, and testing of an agriculture support exoskeleton in adjunct to conventional physiotherapy for farm labourers with chronic low back pain: A two-phase, mixed-methods, quasi-experimental pilot study protocol.

Background Low back pain (LBP) affects 619 million people globally, with projections reaching 843 million by 2050. Farm labourers exhibit markedly higher prevalence than the general population, with lifetime (70–85%), 12-month (15–45%), and point (approximately 30%) prevalences driven by sustained trunk flexion, repetitive manual handling, and limited access to ergonomic or rehabilitative interventions. While conventional physiotherapy is the cornerstone of chronic LBP (CLBP) management, its ef...

Back Pain

Kaur G, Qureshi I, Bagde A, Sarode B, Jolhe DA, Nistane VM• November 6, 2026

PubMed

Sex- and age-specific disparities in low back pain burden attributable to three modifiable risks, 1990-2021: A cross-sectional analysis of the global burden of disease study 2021.

Low back pain (LBP) is the leading cause of global disability, with more than 500 million cases reported in 2020, and its risk patterns vary across regions and demographic groups. Using Global Burden of Disease 2021 data, Disability-Adjusted Life Years (DALYs) attributable to 3 risk factors were analyzed across 204 countries. Age-standardized rates (ASRs) and temporal trends average annual percentage change (AAPC) were calculated. From 1990 to 2021, DALYs attributable to high body mass index (BM...

Back Pain

Ba Y, Yu X, Wu E, Li J• November 6, 2026

PubMed

The influence of high body mass index on asthma: A study integrating GBD 2021 and Mendelian randomization.

Elevated body mass index (BMI) represents a significant adjustable risk element for asthma, posing a considerable worldwide health concern. This research was designed to assess the worldwide impact of asthma due to high BMI between 1990 and 2021, forecast patterns through 2050, and use 2-sample Mendelian randomization (MR) to examine whether elevated BMI is genetically associated with asthma risk, in order to guide preventive approaches. The data for this study were obtained from the global burd...

Asthma

Yao X, Zhang C• November 6, 2026

PubMed

Association between triglyceride-glucose body mass index and future risk of arthritis in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: A national prospective cohort study.

Cardiovascular-kidney-metabolic (CKM) syndrome encompasses interrelated cardiovascular, renal and metabolic disorders. Arthritis is linked to CKM multimorbidity, but the association between triglyceride-glucose body mass index (TyG-BMI), a surrogate marker of insulin resistance and incident arthritis across the CKM spectrum remains unclear. We analyzed data from the CHARLS cohort, including 5018 participants aged ≥45 years with CKM stages 0 to 3. Analytical approaches included multivariable logi...

Cardiovascular

Yan H, Yang Y, Zhao B• November 6, 2026

PubMed

The effect of personal mastery on depression and anxiety in patients with psoriasis: The mediating role of social support and acceptance of illness.

Psoriasis is a chronic skin disease with heterogeneous manifestations and patients frequently experience comorbid depression and anxiety. The purpose of this study is to investigate the influencing factors of comorbid depression and anxiety in patients with psoriasis and analyze the interrelationships between these factors. The study employed a cross-sectional design with a sample size of 235. We used the general information questionnaire compiled by authors and 4 standardized psychometric scale...

Anxiety

Yang YC, Li SJ, Zhang XG, Guo SB, Xue LL, Wei F, Ma XX, Bai YZ• November 6, 2026

PubMed

Association of SII and SIRI with anxiety and depression severity in patients with acute coronary syndrome: A retrospective cross-sectional study.

Emerging evidence indicates that inflammatory mechanisms may play a key role in linking psychological disorders to cardiovascular outcomes. This study aimed to explore the association between anxiety and depression levels and two inflammatory markers, the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammatory Response Index (SIRI), in patients with acute coronary syndrome (ACS). This retrospective cross-sectional study was conducted on 1498 patients with ACS who underwent coronar...

Anxiety

Savarrakhsh A, Gholami-Chaboki B, Eghbali S, Mirbolouk F, Borghei Y, Isanazar A• November 6, 2026

PubMed

Retraction Note: Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease.

Retraction Note to: Cell Death & Diseasehttps://doi.org/10.1038/cddis.2011.2, published online 10 February 2011 The Editors have retracted this article. After publication, concerns were raised regarding some of the data presented in the figures and supplementary materials, specifically:In Fig. 4j–l, the merged image (l) doesn’t fully match the DCX (j, green) and CDK5 (k, red) channels, and there appears to be a duplicated pattern in the top left of the merged image;Fig. 8 panels f and g appear...

Alzheimer’S Disease

Crews L, Patrick C, Adame A, Rockenstein E, Masliah E• November 6, 2026

PubMed

IgD-λ POEMS syndrome presenting with edema, pulmonary hypertension, and renal impairment: A case report.

Rationale: Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-cell disorder, and skin changes (POEMS) syndrome is a rare multisystem syndrome associated with clonal plasma-cell disorders. The IgD-λ subtype is uncommon, and a low-level monoclonal protein may escape detection by routine electrophoresis and immunofixation electrophoresis (IFE), delaying diagnosis. Patient concerns: A 38-year-old woman was admitted in April 2025 with intermittent bilateral lower-extremity edema for >...

Hypertension

Feng J, Zhao J, Song C, Cui H, Lin Q• November 6, 2026

PubMed

Correction: A Machine Learning-Based Model to Predict Overactive Bladder Risk Among US Women: Evidence From the National Health and Nutrition Examination Survey 2011-2018.

In “A Machine Learning–Based Model to Predict Overactive Bladder Risk Among US Women: Evidence From the National Health and Nutrition Examination Survey 2011-2018” [1], the authors noted the following corrections in response to the letter to the editor, authors’ reply, and a full rereview of the published article and the analysis code conducted by the authors. First, the Figure 2B caption has been corrected from the following: The caption now reads: Second, the Figure 4 caption has been clari...

Overactive Bladder

Huang G, Lin S• November 6, 2026

PubMed

Efficacy of diadynamic currents versus transcutaneous electrical nerve stimulation for transcutaneous tibial nerve stimulation in subjects with overactive bladder syndrome: A double-blind randomized controlled trial.

Background In the traditional treatment of overactive bladder (OAB) with transcutaneous posterior tibial nerve stimulation (TTNS), physical therapists currently use only transcutaneous electrical nerve stimulation (TENS). However, the literature has commonly replaced TENS with diadynamic currents for various musculoskeletal pain syndromes. Moreover, no literature describes the use of diadynamic currents in the TTNS procedure. Therefore, our study aimed to determine the efficacy of diadynamic cu...

Overactive Bladder

Tedla JS, Lalaji SL, Midde AK, Papalkar NA, Bindhu Priya N, Sangadala DR, Reddy RS, Mukherjee D, Alamri AM, Alzahrani AS, Alhadi NA• November 6, 2026

PubMed

Socioeconomic status and long-term risk of inflammatory bowel disease: a prospective cohort study with mediation analysis.

Background The association of socioeconomic status with incident inflammatory bowel disease and the contribution of lifestyle factors remain unclear. We aimed to comprehensively investigate the association between socioeconomic status (SES) and the risk of inflammatory bowel disease (IBD), and to assess the mediating effect of lifestyle factors in a prospective cohort. Methods We assessed SES using household income, education level, and employment status, and categorised participants into hig...

Inflammatory Bowel Disease

Zhang Q, Wang Y, Yu S, Zhou Y, Liu S, Li P, Zhang S, Wu S• November 6, 2026

PubMed

Immunometabolic and epigenetic reprogramming in inflammatory bowel disease: from mechanistic circuits to therapeutic targeting.

Inflammatory bowel disease (IBD) is a chronic, immune-mediated disorder of the gastrointestinal tract and an escalating global public health challenge, particularly in newly industrializing regions. Its etiology and pathogenesis remain incompletely understood, although disrupted homeostasis between the intestinal microbiota and the mucosal immune system is implicated. Macrophages and T cells contribute to the balance between tissue injury and repair. Increasing evidence suggests that metabolic s...

Inflammatory Bowel Disease

Han Y, Yi J, Wang X, Li S, Chen M, Xiao J• November 6, 2026