Clinical intelligence & editorial.

PubMed

Bioengineering strategies for off-the-shelf, cell-based cancer immunotherapy.

Cancer immunotherapy has reshaped modern oncology by leveraging immune effector cells to recognize and eliminate malignant tissues. Among cell-based approaches, adoptive cell therapies, most prominently chimeric antigen receptor (CAR) T cells, have produced high response rates and deep remissions in several hematologic malignancies. Despite these clinical successes, broad deployment remains limited by the dominant autologous manufacturing paradigm, which is associated with high per patient cost,...

Cancer Immunotherapy

Barlow BR, Sandoval-Castellanos AM, Canter RJ, Kim J• November 5, 2026

PubMed

Prevalence of Reactive Screening Markers for HIV, Hepatitis B, Hepatitis C, and Syphilis Among Blood Donors at the Provincial Hospital of Sarh, Chad: A Retrospective Cross-Sectional Study.

Introduction Blood transfusion safety remains a challenge in resource-limited settings. This study estimated the prevalence of reactive screening markers for HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis among blood donors at Sarh Provincial Hospital, Chad. Methods This retrospective cross-sectional study used blood bank register data from 18 September to 18 November 2023. Of 2,868 records identified, 27 were excluded and 2,841 donors were analyzed. Screening used rapid...

Syphilis

Mahamat AB, Abdel-Aziz MH, Bechir AB, Djakmoudwé BE, Alio HM• November 4, 2026

PubMed

Correlating Laryngoscopic and Clinical Findings With Airway Intervention in Angioedema.

ABSTRACT Objective(s) To evaluate whether specific presenting symptoms and laryngoscopic subsite involvement in aerodigestive angioedema predict clinical severity, defined by airway intervention, hospital admission, and length of stay (LOS). A secondary objective was to assess the performance of a reduced symptom‐based model for predicting intubation. Methods A retrospective cohort study was performed of adult patients presenting with aerodigestive angioedema at a single tertiary academic me...

Angioedema

Thornton N, Webb K, Bowman CN, Kwak MW, Ali N, Stepp R, York A, Daniero J• November 4, 2026

PubMed

Systemic Sarcoidosis After Polycaprolactone Fillers Successfully Treated with Upadacitinib.

Dermal fillers are widely used in aesthetic medicine but may occasionally induce granulomatous reactions. We describe a case of systemic sarcoidosis developing after polycaprolactone filler injections, successfully treated with upadacitinib. CASE PRESENTATION A 56-year-old woman presented with progressive subcutaneous nodules in the nasolabial folds, chin and jawline that appeared 2 years after aesthetic filler injections with polycaprolactone (Ellansé®; polycaprolactone plus carboxymethylcell...

Sarcoidosis

Behaghel C, Pothen L, Gérard T, Marot L, Baeck M, De Greef A• November 4, 2026

PubMed

Hepatic Sarcoidosis as a Rare Cause of Secondary Hemophagocytic Lymphohistiocytosis.

ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome often triggered by an underlying disease process. Macrophage activation syndrome (MAS) is a secondary HLH phenotype associated with autoimmune disease. A 72-year-old man presented with fever, pancytopenia, hyperferritinemia, splenomegaly, and acute liver injury. Bone marrow biopsy demonstrated hemophagocytosis, supporting HLH. Despite corticosteroid therapy, progressive liver injury prompted liver...

Sarcoidosis

Shariff H, Nair S, Patel A, Martinez Mencia A, Jiang W, Qualtieri J, Binder A, Mendoza F, Sass DA• November 4, 2026

PubMed

Concurrent erythema multiforme and psoriasiform eruption during enfortumab vedotin plus pembrolizumab therapy for advanced urothelial carcinoma.

ABSTRACT Enfortumab vedotin (EV) plus pembrolizumab is an effective first-line treatment for advanced urothelial carcinoma, but clinically significant cutaneous adverse events may require treatment interruption or discontinuation. We report a 74-year-old man with metastatic upper-tract urothelial carcinoma who achieved a complete metabolic and radiologic response after three cycles of EV plus pembrolizumab. After six cycles and before cycle 7, he developed painful plantar lesions that progresse...

Erythema Multiforme

Di Trolio R, Di Lorenzo G• November 4, 2026

PubMed

Decoding Immune Dysregulation in Childhood Idiopathic Nephrotic Syndrome: Insights From Lymphocyte Subsets and Urinary Cytokine Analysis.

Background Idiopathic nephrotic syndrome (INS) is a primary kidney disease of childhood involving podocytes where immune dysregulation is thought to play a major role in pathogenesis. The aim of the study was to evaluate peripheral lymphocyte subsets and urinary cytokines in children with INS to understand the immune mechanisms and their association with steroid responsiveness. Methods This was a prospective longitudinal observational study of children with INS, conducted at a tertiary care h...

Nephrotic Syndrome

Anju Ashok AK, Saharia GK, Satapathy AK, Mangaraj M• November 4, 2026

PubMed

Pathogen-specific positron emission tomography for Enterobacterales bone infection.

Aims Gram-negative bone infections involving Enterobacterales group of bacteria pose a growing concern, especially for orthopaedic surgeries and diabetic ulcers. Current imaging methods either identify morphological changes by CT and MRI, or inflammation, using white blood cell scans or 2-deoxy-2-[18F]fluoro-d-glucose ([18F]-FDG) positron emission tomography (PET). While valuable, these are not specific, resulting in delayed diagnoses. PET/CT using 2-deoxy-2-[18F]fluoro-d-sorbitol ([18F]-FDS) i...

Bone Infection

Gordon O, Napiorkowski A, Flavahan K, De Jesus P, Dikeman DA, Kronenberg A, Archer NK, Jain SK• November 4, 2026

PubMed

Recurrent oesophageal strictures in bullous systemic lupus erythematosus: a case report.

Dear Editor, Bullous systemic lupus erythematosus (BSLE) represents a rare subset of systemic lupus erythematosus (SLE), affecting fewer than 1% of patients. It is characterized by acute-onset vesiculobullous eruptions with subepidermal blistering, linear deposition of immunoglobulin G and complement at the basement membrane zone (BMZ) [1, 2]. Autoantibodies to type VII collagen contribute to dermal–epidermal separation [2, 3]. We report recurrent oesophageal strictures in a patient with refract...

Systemic Lupus Erythematosus

Moniati F, Reynolds JA• November 4, 2026

PubMed

Long-Term Follow-up of Azathioprine-Induced Portosinusoidal Vascular Disease in a Patient With Crohn's Disease.

ABSTRACT Azathioprine is widely used to treat inflammatory bowel disease, organ transplantation, and autoimmune disorders. Hepatotoxicity is a rare but serious complication. We report a 48-year-old man with ileocolonic Crohn’s disease who developed azathioprine-induced portosinusoidal vascular disease (PSVD) after 15 years of treatment. Diagnosis was suspected due to persistent cytopenia (leukopenia and thrombocytopenia) and when transabdominal ultrasonography and upper gastrointestinal endosco...

Crohn's Disease

Azizi F, Ouldgougam R, Aouameur Y, Bourezak SES, Gasri M, Amir ZC, Boudjella MEA• November 4, 2026

PubMed

Prevalence of Contact Sensitization in Patients with Atopic Dermatitis: A Retrospective Study from China.

The prevalence of contact sensitization in atopic dermatitis (AD) has been controversial and remains poorly studied in the Chinese population. This retrospective study aimed to assess the prevalence and differences in contact sensitization between AD and non-AD patients undergoing patch testing in China. We analysed clinical records of 3,487 patients who underwent patch testing from 2018 to 2023, including 146 AD patients and 3,341 non-AD patients. Results demonstrated that contact sensitization...

Atopic Dermatitis

Wang A, Ye C, Fei C, Li Y, Ma Y, Cao T, Wu Y, Cheng Y, Hao F, Zou Y• November 4, 2026

PubMed

Vitiligo Following Dupilumab Therapy for Moderate-to-Severe Atopic Dermatitis: A Case Report with Insight into Type 1/Type 2 Immune Imbalance.

Abstract Dupilumab, a biologic agent, has been widely utilized for its remarkable therapeutic efficacy in treating moderate-to-severe atopic dermatitis (AD). This report presents a case of a 72-year-old male with a 2-year history of AD who experienced complete resolution of AD symptoms after dupilumab treatment. However, hypopigmented macules, consistent with vitiligo, were observed diffusely on the scalp, preauricular region, postauricular region, lateral cervical region, posterolateral cervic...

Atopic Dermatitis

Gong X, Chen J, Jiang J, Mei Q• November 4, 2026