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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 193–204 of 1,604 articles

PubMed

Low tumor burden follicular lymphoma: The state of the art.

Abstract Follicular lymphoma (FL) is the commonest indolent non‐Hodgkin lymphoma. Most patients present with advanced‐stage and are stratified by the Groupe d'Etude des Lymphomes Folliculaires (GELF) criteria into high or low tumor burden (LTB). Randomized trials in LTB FL demonstrated no overall survival advantage with immediate treatment compared to watchful waiting (WW). This led to the widespread practice of WW and the consideration of LTB FL as a single indolent continuum. However, LTB FL...

Follicular Lymphoma
Hapgood G, Tobin J, Kridel R, Kahl B•
PubMed

Pulmonary Sarcoidosis Presenting as a Solitary Pulmonary Nodule With Probable Neurosarcoidosis: A Case Report.

ABSTRACT A 51‐year‐old woman presented with a solitary pulmonary nodule, hilar and mediastinal lymphadenopathy and progressive sensory disturbances. FDG‐PET demonstrated intense uptake in the pulmonary and hilar lesions, while spinal MRI showed thoracic cord enhancement. Lung cancer‐associated paraneoplastic neurological syndrome was initially suspected. Biopsies of the endobronchial lesion and a mediastinal lymph node revealed noncaseating granulomas without malignancy. Ocular involvement and...

Sarcoidosis
Homochi M, Shirai T, Sato T, Mukai A, Tanaka T, Hashiba F, Masaki A, Naiki-Ito A, Takakuwa O, Kanemitsu Y•
PubMed

Latent Profile Subtypes of Depressive Symptoms and Associated Factors Among Elderly Patients with Chronic Heart Failure.

Objective To identify latent subtypes of depressive symptoms and their associated factors among elderly patients with chronic heart failure (CHF), so as to provide reference for developing targeted psychological intervention strategies. Methods A cross-sectional survey enrolled 423 hospitalized elderly CHF patients from June 2025 to May 2026. Assessments included SDS, SAS, Family APGAR, MLHFQ and PNI. Different from conventional SDS total-score-based severity grouping, latent profile analysis...

Chronic Heart Failure
Hu Q, Shao Y, Yu S, Yang X, Li M, Xia Z, Yang X, Wang X•
PubMed

Association Between Time Perspective and Fear of Disease Progression in Patients with Chronic Heart Failure: A Cross-Sectional Study.

Purpose To describe the level of fear of disease progression (FoP) in patients with chronic heart failure (CHF) and to examine whether individual dimensions of time perspective are associated with FoP. Patients and Methods In this single-center cross-sectional study, we surveyed a convenience sample of 254 patients treated in the cardiovascular department of a tertiary hospital in Nantong between December 2025 and August 2026. Time perspective was measured with the Chinese version of the Zimb...

Chronic Heart Failure
Ding Y, Ma D, Tang J, Chen S, Zhou X•
PubMed

Network analysis of attention deficit hyperactivity disorder traits and mental health indicators in Brazilian adults.

Attention-Deficit/Hyperactivity Disorder (ADHD), a neurodevelopmental disorder characterized by behavioral traits such as inattention, hyperactivity, and impulsivity, has been widely associated with mental health impairments. However, the presence of these traits alone does not determine diagnosis, as they must also cause significant functional impairment for the individual to fulfill diagnostic criteria. Therefore, this study aimed at exploring how ADHD traits are associated with mental health...

Attention-Deficit Hyperactivity Disorder
Quintanilha DF, Pereira DF, Abramov DM•
PubMed

Clinical features and outcomes of perianal disease in pediatric-onset Crohn's disease: A comparative analysis according to age at diagnosis.

Background This study aimed to investigate the clinical features, treatment responses, and outcomes of pediatric patients with Crohn’s disease (CD) and perianal disease (PD) in China, with a particular focus on age at diagnosis. Methods We retrospectively analyzed 144 children diagnosed with CD between 2015 and 2024. Patients were divided into PD and non-PD groups and further stratified by age at diagnosis into very-early onset (VEO-IBD, < 6 years) and late-onset disease (LO; 6–18 years). The...

Crohn's Disease
Mi M, Jin M, Meng L, Gong Y, Zhong X•
PubMed

Juvenile idiopathic arthritis is associated with reduced levels of biochemical bone status indices reflecting altered bone formation.

Introduction Individuals with juvenile idiopathic arthritis (JIA) are at increased risk of impaired bone health and fractures. This prospective case-control study assessed bone mineral density (BMD) and bone and cartilage biomarkers in children with JIA and healthy controls. Methods Fifty-one individuals with well-characterized JIA (age 1.6–17.9 years) and 61 age-matched controls from the same region were included. Joint erosions were assessed radiographically, and BMD was measured by digital...

Juvenile Idiopathic Arthritis
Lewander P, Atanasova D, Dahle C, Wetterö J, Sjöwall C, Magnusson P•
PubMed

A Journey Map of Health Behaviour Decision-Making Among Patients with Type 2 Diabetes Mellitus Who are Repeatedly Hospitalized: A Longitudinal Qualitative Study.

Background Health behaviour decision-making is central to type 2 diabetes mellitus management, but remains complex and context dependent after repeated hospitalisations. Research has focused on health behaviours and associated factors, overlooking patient-centred decision-making across care stages and limiting stage-specific decision support and continuity-of-care strategies. Methods A longitudinal qualitative study was conducted in mainland China, with data collected from October 2025 to Mar...

Type 2 Diabetes Mellitus
Mao H, Zhang M, Hu W, Yang W, Yuan B, Li T, Lu Y, Chen W, Liu M•
PubMed

Correction: Hyperoxygenation Attenuated a Murine Model of Atopic Dermatitis through Raising Skin Level of ROS.

Notice of Republication This article was republished on October 19, 2026 to correct the author list and remove Yeo Kyong Lee from the byline. Please download this article again to view the correct version. The originally published, uncorrected article and the republished, corrected article are provided here for reference. Supporting information

Atopic Dermatitis
PLOS One Editors•
PubMed

Neoadjuvant Apalutamide With or Without Abiraterone Acetate Plus Prednisone and Gonadotropin-Releasing Hormone Agonist Prior to Nerve-Sparing Radical Prostatectomy in High-Risk Prostate Cancer: Protocol for a Randomized Phase 2 Trial.

Abstract Background Radical prostatectomy (RP) is an accepted, definitive treatment for appropriately selected men with high-risk localized prostate cancer (PCa). However, neoadjuvant androgen receptor inhibition prior to RP is not currently the standard of care. Wide resection of the neurovascular bundles may improve local oncologic control but can adversely affect postoperative erectile function and urinary continence. Apalutamide directly inhibits the androgen receptor, while abiraterone ac...

Prednisone
Zhang AY, Stein MN, Ghodoussipour S, Kim IY•
PubMed

Non Pharmacological Pain Management in Sickle Cell Disease, a Narrative Review.

Background Pain is a major cause of morbidity, disability, and reduced quality of life among people living with sickle cell disease (SCD). Although pharmacological treatment remains essential, non pharmacological interventions may provide complementary strategies for pain coping and symptom management. However, the strength of evidence supporting individual interventions varies considerably. Objective This narrative review aimed to critically evaluate the evidence for non pharmacological inte...

Pain Management
Daudi K, Bashir J, Aja L•
PubMed

Correction: Diagnostic accuracy of digital technologies compared with 12-lead ECG in the diagnosis of atrial fibrillation in adults: A protocol for a systematic review.

The fourth author’s initials appear incorrectly in the citation. The correct citation is: Sheron VA, Surenthirakumaran R, Gooden TE, Lip GYH, Thomas GN, J. Moore D, et al. (2024) Diagnostic accuracy of digital technologies compared with 12-lead ECG in the diagnosis of atrial fibrillation in adults: A protocol for a systematic review. PLoS ONE 19(5): e0301729. https://doi.org/10.1371/journal.pone.0301729.

Ecg
Sheron VA, Surenthirakumaran R, Gooden TE, Lip GYH, Thomas GN, J Moore D, Nirantharakumar K, Kumarendran B, Subaschandran K, Kanesamoorthy S, Uruthirakumar P, Guruparan M, NIHR Global Health Research Group on Atrial Fibrillation Management•

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