Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Social isolation is a growing public health concern, particularly among cancer survivors who face persistent challenges in maintaining social connections following treatment. While its impact on mental health is increasingly recognized, the underlying pathways and contextual differences across rural and urban settings remain underexplored. This study aimed to identify the psychosocial and personal factors that contribute to perceived social isolation among U.S. cancer survivors and to assess how...
Cancer
Avishek Choudhury, Christopher W. Wheldon, Safa Elkefi, Priyanka Dixit•
Palliative care (PC) is crucial for children with cancer to alleviate suffering and enhance quality of life. However, continuity of pediatric palliative care (PPC) can be disrupted by factors such as lack of knowledge, stigma, bureaucratic hurdles, inadequate referral systems, and staffing shortages. There is limited data on the prevalence and factors associated with non-continuity of PPC in Uganda. This study explores the prevalence and factors contributing to non-continuity of PC among childre...
Cancer
Miriam Ajambo, Savio Mwaka, Joseph Gavin Nyanzi, Damalie Nalwanga, Joyce Balagadde, Joseph Rujumba•
Advancements in deep learning technologies and an increase in medical data have enhanced the accuracy of disease diagnosis and treatment strategies. Notably, significant progress has been made in the use of deep learning-based time-series prediction models for short-term disease onset prediction and analysis of important features. However, research on explainable deep learning for long-term disease progression, such as cancer and chronic diseases, still faces challenges. The difficulty in estima...
Introduction: Adults undergoing treatment for breast cancer (BC) are advised to participate in regular exercise. However, many struggle to exercise consistently due to the side effects of systemic treatments including nausea, fatigue, and pain. In adults with newly diagnosed BC, this trial will evaluate the effectiveness of a new exercise intervention, compared with usual care, on outcomes including health-related quality of life (HRQoL). Materials: This randomised controlled trial is underway a...
Cancer
Susan Stinton, Dale Edwick, Chloe Maxwell-Smith, Natasha Bear, Lauren J. Breen, Alejandro Dominguez Garcia, Elizabeth Dylke, Kate Edwards, Sally Lynch, Adam Lloyd, Barbara Mullan, Niamh Moloney, Ru-Wen Teh, Carol Watson, Kylie Hill•
Individuals with breast cancer (BC) experience significant psychological distress, yet their utilization of mental health services remains low. This study identified key factors influencing help-seeking behavior through integrated Theory of Planned Behavior (TPB) and Health Belief Model (HBM) frameworks. We conducted in-depth interviews (IDIs) with eight BC patients and nominal group technique (NGT) with six health professionals, followed by Fuzzy Delphi Method (FDM) to assess expert consensus....
Cancer
Nurdiana Mohammad Hussin, Nik Ruzyanei Nik Jaafar, Idayu Badilla Idris, Azmawati Mohammed Nawi•
Patients with cancer who develop acute abdomen are at high risk of rapid clinical deterioration and often require emergency surgery and intensive care. This retrospective cohort study evaluated the impact of implementing a Rapid Response System (RRS) on survival among 274 patients admitted for emergency surgery at a tertiary cancer center in Korea (145 pre-RRS, 129 post-RRS). Although the post-RRS group had a higher burden of severe illness, including more metastatic disease and higher APACHE II...
Cancer
Jae Hoon Lee, Sang Yun Jung, Ki Ho Yu, Mee Hee Shin, Yun Jung Choi, Ra Mi Choi, Woo Jin Seo, Sang Hee Park, Won Ho Han•
Introduction: Given the high recurrence rate of bladder cancer (BCa) and the significant adverse effects associated with conventional treatments, it is urgent to search for new clinical therapeutic targets and safer natural-derived compounds. Resveratrol (Res) has been demonstrated to exhibit cytotoxicity against various tumors. However, the signaling pathways and targets involved in inhibition of BCa cells still need further exploration. This study aims to investigate the mechanism of Res in Bc...
Cancer
Chao Feng, Guodong Chen, Yan Shu, Jing Chen, Wenxin Ye, Ligang Ren•
Antibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, can exhibit high tolerance to the last-resort antibiotic meropenem. Meropenem tolerance is associated with formation of cell wall-deficient spheroplasts that readily recover to rod shape and normal growth upon removal of the antibiotic. Both the true prevalence of tolerance, and genetic mechanisms underlying it, remain po...
Antibiotic
Trevor Cross, Facundo Torres, Nadia Nikulin, Abigail P. McGee, Leena Jalees, Rhea Balakrishnan, Tolani Aliyu, Lars F. Westblade, Abhyudai Singh, Tobias Dörr•
Background: Emerging evidence suggests that the time in the day of vaccination may influence post-vaccination immunogenicity. The main objective of this study was to assess the association between the time of vaccination and the anti-EBOV GP1,2 IgG antibody response at 12 mo following vaccination against Ebola virus disease (EVD). Methodology/Principal Findings: This study utilized data from a randomized, double-blind, placebo-controlled international phase 2b clinical trial (PREVAC) evaluating...
Vaccines And Immunization
Ange-Marie D. Kpetigo, Marie Alexandre, Aboubacar Camara, Abdoul Beavogui, Seydou Doumbia, Mark Kieh, Bailah Leigh, Samba Sow, Linda Wittkop, Anne-Aygline Soutthiphong, Irina Maljkovic Berry, Suzanne Fleck, Pauline Akoo, Benjamin Hamze, Deborah Watson-Jones, Jens H. Kuhn, Brian Greenwood, Laura Richert, Yazdan Yazdanpanah, Yves Lévy, Rodolphe Thiébaut, Mélanie Prague, PREVAC Study Team, Edouard Lhomme•
Objective: Liquid biopsy for detection of circulating tumor DNA (ctDNA) offers a promising, non-invasive strategy for real-time monitoring of cancer. We aimed to develop a universal and sensitive one-tube droplet digital PCR (ddPCR) multiplex assay able to detect ctDNA in plasma from metastatic prostate cancer (PCa) patients. Methods: Publicly available array data are applied to identify methylation signatures specific to both normal and cancerous prostate tissue. The assay is based on the highl...
Pcr
Søren Kahns, Ahmed H. Zedan, Mads M. Aagaard, Luisa M. D. Canto, Sanne Kjær-Frifeldt, Stine V. Eriksen, Christine V. Madsen, Jonna S. Madsen, Palle J. S. Osther, Torben F. Hansen, Rikke F. Andersen•
Youth Mental Health First Aid (YMHFA) is a training program that prepares adults to recognize and respond to adolescents’ mental health concerns. Although widely used in schools and community organizations internationally, there has been no recent synthesis focused on post-2019 implementation and effectiveness evidence in youth-serving settings. This scoping review examined the extent, range, and characteristics of the predominantly U.S.-based evidence on YMHFA in youth-serving settings. We cond...
Mental Health
Irfanul Alam, Marie Barnard, Jessica Osborne, Divya Chandran Geetha Kumari, Clyde King Jr, M. Allison Ford, Hannah K. Allen, Sara J. Hendrix, Gracie Avery, Guadalupe Alvarado•
Serum uric acid (UA) is linked to non-alcoholic fatty liver disease (NAFLD), but its role in hypertensive populations remains unclear. This cross-sectional study investigated their association in 1,058 patients with hypertension. Multivariate logistic regression analysis confirmed that UA was independently correlated with NAFLD, whether as a continuous variable or a categorical variable. According to the fully adjusted model, the risk of NAFLD increased by 0.2%, 347.2% and 91.7% for each unit in...
Hypertension
Yan Zhao, Zhenwei Wang, Yang Liu, Ting Yang, Zhuang Li, Ao Gao, Lei Cao, Chongyang Ma•
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