Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
There is an error in affiliation 1 for author Anan S. Jarab. The correct affiliation 1 is: Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology. Irbid 22110, Jordan.
Objective: This study aims to investigate the association between multimorbidity and the incidence of depression in the middle-aged and elderly populations in China, focusing on the impact of multiple chronic diseases on mental health outcomes. Methods: This research comprises a rigorous retrospective cohort study utilizing the esteemed China Health and Retirement Longitudinal Study (CHARLS) data. Follow-up data were meticulously analyzed from 2013 (Wave 2) to 2020 (Wave 5), with data from 2015...
Background: Depression among young people is a global public health issue, particularly common in low-resource settings like Ghana and Zimbabwe. Affecting around 10% of young people, depression often emerges between ages 15 and 24 and remains largely untreated due to stigma, limited resources, and cultural beliefs. This study explored the explanatory models of depression among Ghanaian and Zimbabwean young people, from the perspectives of young people, caregivers, healthcare workers, teachers, a...
Introduction: Cardiovascular disease (CVD) remains the leading cause of death globally, and numerous patients undergoing cardiovascular surgery rely heavily on informal care partners, often spouses or close family members for support. While much of the existing literature focuses on caregiver burden, particularly in dementia-related conditions, less is known about the specific factors influencing the quality of life (QoL) of care partners in the context of surgical cardiovascular interventions....
Social anxiety disorder is common among patients considered for metabolic and bariatric surgery (MBS). The combination of social anxiety with obesity may, however, be associated with a higher risk for adverse outcomes after surgery. In this nationwide, registry-based, matched cohort study, all patients who underwent primary MBS in Sweden from 2007 until 2019 and who had a diagnosis of moderate to severe social anxiety disorder (n = 586) were matched using a Propensity score to controls who under...
Background: Vaginal cervical cerclage and progesterone are established treatments for prevention of pregnancy loss and prematurity. There is limited data to assess the effect of these treatments in combination. The objective of this study was to investigate the association between progesterone and no progesterone treatment on pregnancy outcomes in women at high risk of preterm birth who had received a vaginal cervical cerclage. Methods and findings: This is a secondary post-hoc analysis of women...
Efficacious and well-tolerated systemic, oral treatments for psoriasis are needed. We report preclinical and phase 1c (NCT06808815) results for DC-806, a small molecule interleukin (IL)-17 inhibitor, for the treatment of mild-to-moderate psoriasis. Preclinical results demonstrated DC-806 targets IL-17AA and IL-17AF with secukinumab-like therapeutic efficacy. In the phase 1c trial, 32 patients consented to receive twice daily (BID) doses of placebo or DC-806 (200 mg or 800 mg) for 28 days. No ser...
Environmental metals are established thyroid carcinogens, yet how their co-exposure collectively reshapes carcinogenic mechanisms remains elusive. This study used ICP-MS to quantify plasma concentrations of 18 metals in 368 thyroid cancer patients and matched controls, with free thyroxine (FT4) levels abstracted from medical records. Subsequently, we applied integrative statistical modeling comprising WQS regression, BKMR modeling, interaction analysis, and causal mediation analysis to elucidate...
The removal of toxic heavy metals from wastewater remains a major environmental challenge due to their non-bio-degradability, persistence, and adverse health effects. In this work, a novel DES-assisted microwave hydrothermal route was developed for the rapid synthesis of hierarchical Na A. zeolite (NaAZ), offering a new pathway toward enhanced adsorption performance. Structural characterization (X-ray diffraction (XRD), SEM, Fourier Transform Infrared Spectroscopy” (FT-IR(Brunauer-Emmett-Teller...
Ischemic stroke is a cerebrovascular disease that can cause long-term neurological impairment, dementia, or death. It is the third most common cause of disability and the second leading cause of death worldwide. The aim of this study was to explore the underlying molecular mechanisms and potentially effective therapeutic drugs for ischemic stroke. Single-cell seq data (GSE174574) were downloaded from the Gene Expression Omnibus (GEO) database, and dimensionality reduction clustering was performe...
Introduction: Stroke is a leading cause of long-term disability and mortality worldwide. Survivors can experience a range of physical and emotional challenges, often leading to depression, anxiety, and a poorer quality of life. Creative arts therapies (CATs), an umbrella term encompassing music, art, dance/movement, drama, and creative writing therapies, have increasingly been explored in stroke survivor populations as interventions to improve psychological outcomes. Qualitative analysis suggest...
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and the elderly worldwide. Although prophylactic monoclonal antibodies and RSV vaccines are available for preventing severe RSV infection, unmet medical need remains for an effective antiviral agent to treat patients who do not benefit from these interventions. Ziresovir (formerly AK0529) is a potent, selective, and orally bioavailable RSV fusion inhibitor with proved antiviral efficacy and clin...
