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In Fig 1 , the label “Cardiac Deths” should have been “Cardiac Death”. Please see the correct Fig 1 here. 10.1371/journal.pone.0340417.g001 Fig 1 Five-year Trends in SMR for All-cause and Heart Disease Mortality (ICD-10: I20–I52). SMR, standardized mortality ratio. Blue line represents the entire country; Orange line represents Tsunan. In the Acknowledgement statement, the name“T. Yasuzawa” should have been “T. Anzawa”. The correct statement is: We express our deepest gratitude to M. Tsuchiya...
The Funding statement for this article is incorrect. The correct Funding statement is as follows: We are grateful to the Alzheimer’s Society (grant 518) and the Elizabeth Blackwell Institute at the University of Bristol and the Wellcome trust institutional strategic support fund (204813/Z/16/Z) who supported Dr. Sinclair and Dr. Morisaki during this research project. Prof. Khandaker is supported by the Wellcome Trust (Grant No. 201486/B/16/Z), the Medical Research Council, UK (Grant No. MC_UU_00...
Alzheimer’S Disease
Mizuki Morisaki, Farnoosh Rezaali, Laurie C. Lau, Delphine Boche, Golam M. Khandaker, Gustavo Turecki, Lindsey I. Sinclair•
Executive function can be defined as the combination of goal representation in working memory and the inhibition of goal-irrelevant responses. This paper comprises two complementary studies that assess these core components of executive function orthogonally and examine their correlation with ASD and ADHD traits in the general population. Both studies utilized a paradigm with two tasks, each assessing working memory and one type of inhibitory control concurrently: the modified flanker task, whic...
Objective: To establish a systematic, standardized, and operational model of home pharmaceutical care for patients with anticoagulant treatment in county-level medical community. Methods: A home pharmaceutical care service team was constituted by pharmacists and physicians from the county-level medical community. A home-based pharmaceutical care survey was conducted for patients with long-term oral anticoagulants (VKAs, rivaroxaban, dabigatran and apixaban). The patients’ awareness and adherence...
Anticoagulation
JianAo Song, Bin Chen, Jinhui Sun, KaiZhan Zhuang•
Background: Burkholderia pseudomallei is an environmental bacterium that causes melioidosis, a life-threatening disease prevalent in tropical regions. Accurate detection of B. pseudomallei in the environment is essential for identifying areas that pose an infection risk. This study aimed to evaluate culture- and real-time polymerase chain reaction (PCR)-based methods for detecting B. pseudomallei directly in soil samples, and to assess its environmental prevalence in relation to antibody levels...
Pcr
Didtawa Suttisak, Charlene Mae Salao Cagape, Rathanin Seng, Natnaree Saiprom, Wongwarut Boonyanugomol, Kamolchanok Rukseree, Paul J. Brett, Mary N. Burtnick, Narisara Chantratita•
Objective: The Braden Skin Score (BSS) is a validated tool for assessing pressure injury risk. This study aimed to investigate whether BSS can also predict the risk of developing Acute Respiratory Distress Syndrome (ARDS) in elderly sepsis patients in the intensive care unit (ICU). Background: ARDS is a common and serious complication in ICU patients with sepsis, associated with prolonged hospitalization, metabolic disorders, and increased mortality. Elderly sepsis patients are particularly vuln...
Borrelia burgdorferi, one of the most prevalent tick-borne pathogens, can cause a complex and multisystem illness called Lyme disease, where there has been an unmet need for novel therapeutic or preventive strategies. We previously identified an essential protein-protein interaction (PPI) event in B. burgdorferi involving two unique proteins, BB0323 and BB0238; herein, we show that this PPI is indispensable for long-term borrelial survival in mammals and explore its potential as a novel target f...
Lyme Disease
Sandhya Bista, Kalvis Brangulis, Bibek Bhattachan, Shelby D. Foor, Michael H. Ronzetti, Sankalp Jain, Jenna Miller, Jothy Lachumy Subramanion, Chrysoula Kitsou, Vipin S. Rana, Ganesha Rai, Alexey V. Zakharov, Anton Simeonov, Bolormaa Baljinnyam, Utpal Pal•
Background: Diet and uric acid are closely linked to the formation of kidney stones. However, the specific dietary indices associated with kidney stone risk and the mediating role of uric acid remain unclear. This study investigates the association between four dietary indices and kidney stone risk while exploring the mediating role of uric acid. Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES). Four dietary indices were calculated: the Mediterranean...
Digital cognitive behavioral therapy for insomnia (dCBT-I) is effective in treating insomnia, but adherence remains a major challenge in real-world applications. Machine learning (ML) offers potential in predicting healthcare utilization. This study applied ML techniques to predict adherence to dCBT-I based on participant baseline characteristics. This pilot real-world study included 75 individuals (69% female; 41% aged 35–44 years) with insomnia symptoms (Insomnia Severity Index, ISI ≥ 8) who p...
Insomnia
Rose Wing Lai So, Kit Ying Chan, Christopher Chi Wai Cheng, Ngan Yin Chan, Shirley Xin Li, Joey Wing Yan Chan, Steven Wai Ho Chau, Yun Kwok Wing, Tim Man Ho Li•
Introduction: Engaging community members and context experts is increasingly recognized as key to developing research that is responsive to community needs. Here, we describe a protocol for incorporating stakeholder feedback using rapid qualitative techniques into OPTIMUM (Optimizing Pain Treatment In Medical settings Using Mindfulness), a pragmatic clinical trial comparing a telemedicine-delivered mindfulness-based stress reduction intervention to usual care to address chronic low back pain. Th...
Back Pain
Isabel J. Roth, Elondra D. Harr, Christine R. Lathren, Jessica L. Barnhill, Ruth D. Rodriguez, Jose E. Baez, Natalia E. Morone•
Background: Asthma has been shown to have a significant association with the diagnoses of mental health disorders, including depression; however, information from India is scarce. Objectives: The study aims to estimate the prevalence of depression in asthma patients and identify associated risk factors. Methods: A total of 248 participants aged 18 and above who presented to the pulmonary medicine outpatient clinic of the Christian Medical College, Vellore, Tamil Nadu, India, were recruited. Soci...
Asthma
Anushka Kataria, Jefferson Daniel, Barney Isaac, Balamugesh Thangakunam, Jesson Paulson Illimoottil, Reka Karuppusami, Devasahayam J. Christopher•
Objective: This study employs bioinformatics analysis with the objective of identifying commonly differentially expressed genes (DEGs) in ulcerative colitis (UC) and rheumatoid arthritis (RA), as well as exploring their underlying molecular mechanisms. By doing so, it aims to provide a theoretical basis for investigating the potential associations between these two diseases and developing novel therapeutic strategies. Materials and methods: We downloaded multiple gene expression datasets for Rhe...
Arthritis
Peng-fei Han, Wei-rong Cui, Fang-zheng He, Tao Wu, Chang-sheng Liao•
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