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Los Tuxtlas Biosphere Reserve is one of the last remaining areas of primary tropical rainforest in Mexico. This fragile ecosystem heavily reduced by human perturbations is part of the Mesoamerican hotspot. The reserve harbors many endemic species. Thus, identifying, cataloging, and studying the biodiversity of this ecosystem has been of utmost importance. A promising approach for fast species identification to assess biodiversity is the use of DNA barcoding techniques. However, these techniques...
Genetics
David José Martínez Cano, Víctor Hugo Reynoso, María de Lourdes Vázquez-Cruz, Edyciel Jordán Alvarado-Robledo, Yesenia Ithaí Ángeles-López, Eugenia Zarza•
Discerning the nature of the last common ancestor of land plants (embryophytes) and algae allows to retrace the adaptations that ushered in the conquest of land by plants. For this, the closest streptophyte algal relatives of embryophytes hold key information. Albeit initially coming as a surprise due to their plain body plans, all major phylogenomic efforts have concluded that the Zygnematophyceae are the algal sisters to land plants. The Zygnematophyceae are the streptophyte algal class with t...
Genetics
Maaike J. Bierenbroodspot, Cäcilia F. Kunz, Elisa S. Goldbecker, Maike Lorenz, Iker Irisarri, Thomas Pröschold, Tatyana Darienko, Jan de Vries•
Background: The cardiovascular and mortality benefits of achieving guideline-recommended concentrations of low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol with statins in primary prevention remain uncertain. Methods and findings: In this new-user cohort study, we used electronic healthcare databases from Hong Kong (HK), New Zealand (NZ) and the United Kingdom (UK) to identify 185,237 patients initiating statins between 1 January 2007 and 31 December 2012 (wit...
Cardiovascular
Joseph Edgar Blais, Ralph Kwame Akyea, William Harrison, Amy Hai Yan Chan, Wenfang Zhong, Stephen Franklin Weng, Kebede Abera Beyene, Wallis C. Y. Lau, Kenneth K. C. Man, Nadeem Qureshi, Esther Wai Yin Chan, Ian Chi Kei Wong, Jeff Harrison•
Background: Preterm birth and Neonatal Intensive Care Unit (NICU) admission are significant stressors that heighten maternal anxiety. Although RCTs have reported that music-based interventions used alongside usual care (UC) are effective and low-cost in reducing maternal anxiety, evidence from India remains limited. Objective: Primary objective is to assess the impact of listening to recorded classical Indian Instrumental Saraswati Veena music (Ragas Kalyani and Hindolam) (30-minutes/day over 7-...
Aspartame, a widely used artificial sweetener, has raised significant concerns regarding its safety, especially in light of the rising incidence of Alzheimer’s Disease (AD). However, systematic investigations into aspartame’s potential neurotoxicity and its role in AD pathology remain limited. In this study, we employed an integrated approach combining network toxicology predictions, molecular docking, and in vitro validation to explore the neurotoxic mechanisms of aspartame in AD. By analyzing...
Background: Pandemic influenza preparedness in high-resource nations has traditionally relied on large antiviral stockpiles, typically targeting coverage for 25% of the population. This inventory-based benchmark focuses on cumulative disease burden but often overlooks the inelastic capacity of healthcare systems to manage acute surges. As multi-billion-dollar inventories reach expiration, we evaluated whether static stockpiles remain a viable strategy for preventing healthcare system collapse du...
Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacterial metabolite HMB-PP is sensed by a specialized population of Vγ9Vδ2+T-cells, which we now report can potently suppress growth of endogenous fungi in human intestinal organ cultures. In healthy intestine, HMB-PP-stimulated Vδ2+ T-cells restricted outgrowth of keystone fungus Candida albicans via a...
Crohn's Disease
Liya Mathew, Sean L. Carlson, Michael Savage, Claire Pardieu, Megan B. O’Brien, Ellie Crawley, Paul Harrow, Ann-Kristin Kaune, Edward Devlin, Emily L. Priest, Marilena Crescente, Kimberly Martinod, James Boot, SoFong Cam Ngan, Marco Gasparetto, Klaartje Kok, James O. Lindsay, Jonathan P. Richardson, Julian R. Naglik, Andrew J. Stagg, Matthias Eberl, Siu Kwan Sze, Carol A. Munro, Neil E. McCarthy•
Ulcerative colitis (UC) is characterized by epithelial barrier disruption, mucosal immune activation, and sustained intestinal inflammation. We developed a biologically interpretable public-transcriptomic signature using Gene Expression Omnibus datasets GSE75214, GSE38713, and GSE92415. A literature-curated panel of 35 mucosal barrier injury-related genes was integrated with differential expression, LASSO regression, random forest prioritization, and ridge logistic regression. Six genes (LCN2, D...
Objective: This study aimed to investigate the association of an Online Co-care Management (OCCM) model with changes in glycemic control and metabolic indicators among patients with type 2 diabetes mellitus (T2DM). Methods: Based on clinical follow-up records, we conducted a retrospective cohort study with a propensity score (PS)-matched control group.The OCCM group included patients enrolled in the integrated care clinic from 2022 to 2025 (n = 406). Among patients who did not participate in OCC...
Background: Urogenital schistosomiasis (UGS) remains a significant public health issue in Tanzania, co-infection with urinary tract infections (UTIs) can complicate diagnosis due to overlapping symptoms. Additionally, gastrointestinal carriage of multidrug-resistant bacteria (MDRB) increases risks of self-infection and transmission to others. Primary school-aged children in rural settings are particularly at risk for both diseases due to poor water sanitation and risky behaviors. This study repo...
Bacterial Urinary Tract Infection
Johannes Rukyaa, Prisca Damiano, Vitus Silago, Domenica Morona, Jeremiah Seni, Humphrey D. Mazigo, Stephen E. Mshana•
Diarrhea is a leading cause of pediatric morbidity and mortality worldwide, frequently caused by various bacterial, viral, and protozoan pathogens. Identification of these pathogens is important in clinical settings for proper management of the infection. Conventional stool culture technique is time-consuming for the detection of diarrheagenic pathogens. In addition, these traditional procedures lack sensitivity, require a specific laboratory structure, and well-trained staff. Conversely, multip...
Pcr
Goutam Chowdhury, Melissa Glenda Lewis, Alok Deb, Mamta Chawla-Sarkar, Sandipan Ganguly, Paulami Dutta, Santasabuj Das, Asish K. Mukhopadhyay, Thandavarayan Ramamurthy•
Background: Ambulatory blood pressure monitoring (ABPM) is the reference standard for diagnosing hypertension (HTN), but its use in routine practice remains limited because of cost, availability, and patient burden. Automated office blood pressure (AOBP) has been proposed as a practical alternative, although its performance relative to ABPM remains uncertain. Objectives: To evaluate the agreement and diagnostic performance of 30-minute AOBP compared with 24-hour ABPM and to identify optimal cut-...
Blood Pressure
Ai Cao My Bui, Quynh Tran Nhat Nguyen, Anh Ngoc Minh Bui, Minh Vu Phuc Ha, Nhan Phu Nguyen, Thy Ha Anh Nguyen, Nhan Quoc Dang, Phuong Minh Tran, Tu Vu Kha, Nhu Dong Phuong Nguyen, Liem Diep Bao Le, Huy Hoai Tran, Dung The Bui, Nghia Phu Nguyen•
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