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Enulose (lactulose)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Lactulose, a synthetic derivative of lactose, is an ammonia detoxicant.

USES: This drug is used by mouth or rectally to treat or prevent complications of liver disease (hepatic encephalopathy). It does not cure the problem, but may help to improve mental status. Lactulose is a colonic acidifier that works by decreasing the amount of ammonia in the blood.

It is a man-made sugar solution.

Generic name: lactulose
Pronunciation: (LACK-tew-lohss)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

Today’s intelligence on Enulose

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Indications

The following indications are listed for Enulose:

  • Constipation
  • Hepatic Encephalopathy
  • Hyperammonemia

Also known as: Abnormally Elevated Blood Ammonia, Ammonemia, Portal Systemic Encephalopathy.

Dosing

Each 15 mL of commercially available lactulose solution provides approximately 10 g of the drug; corresponding doses provided by 2.5, 5, 7.5, 10, 30, 40, 45, 90, 150, and 300 mL of the commercial solution are approximately 1.67, 3.3, 5, 6.67, 20, 27, 30, 60, 100, and 200 g, respectively. Following reconstitution of the oral powder as directed, a 10 or 20 g dose is provided by the total volume.

Drug interactions

There is no enhanced messaging for this drug.

Contraindications

There is no enhanced messaging for this drug.

Adverse reactions

There is no enhanced messaging for this drug.

Precautions

No enhanced messaging available.

ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data