Indapamide (indapamide)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Indapamide is a thiazide-like diuretic and antihypertensive agent.
Thiazide-like diuretics are sulfonamide derivatives that lack the benzothiadiazine ring found in thiazide diuretic (e.g., hydrochlorothiazide) chemical structures. The thiazide-like diuretic indapamide contains only one sulfonamide group and is pharmacologically similar to thiazide diuretics. Indapamide reduces the reabsorption of sodium and chloride, via sodium/chloride cotransporter inhibition, from the distal convoluted tubule of the nephron.
This results in increased delivery of sodium to the collecting duct, thus promoting natriuresis, increasing exchange with potassium and magnesium and decreasing intravascular volume.
Indapamide is rapidly and completely absorbed following oral administration; peak blood levels occur in approximately 2 hours. Food does not reduce the bioavailability of indapamide. Indapamide undergoes biphasic elimination with a terminal elimination half-life of approximately 14-16 hours.
Indapamide protein binding is 71-79%. Indapamide is extensively metabolized in the liver; <7% of unchanged drug is excreted in the urine. A minimum of 70% of a single oral dose is eliminated by the kidneys and an additional 23% in the GI tract, probably including the biliary route.
USES: Indapamide is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen. This drug is also used to treat high blood pressure.
Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Indapamide is a "water pill" (diuretic) that causes you to make more urine. This helps your body get rid of extra water and salt.
Generic name: indapamide
Pronunciation: (in-DAP-a-mide)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Indapamide
Indications
The following indications are listed for Indapamide:
- Edema
- Hypertension
Also known as: Edematous Sodium Retaining Conditions, Elevated Blood Pressure, Essential Hypertension, Hyperpiesia, Hyperpiesis, Hypertensive Disorder, Systemic Arterial Hypertension.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
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No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
*Anuria.
*Known hypersensitivity to indapamide, any ingredient in the formulation, or to other sulfonamide-derived drugs.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
Most common adverse reactions to indapamide are hypokalemia (dose-related), other fluid and electrolyte imbalances, dizziness, headache, fatigue, weakness, and muscle cramps.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
Safety and effectiveness of indapamide have not been established in children <18 years of age.
There are no adequate or well-controlled data using indapamide in pregnant women; however diuretics are known to cross the placenta and appear in cord blood. Indapamide did not affect postnatal development of the offspring of rats and mice treated with the drug during gestation.
The manufacturer states to use indapamide during pregnancy only when clearly needed; risks of such use include fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in the adult. The manufacturer states diuretics do not prevent or treat toxemia of pregnancy; routine use of diuretics in an otherwise healthy pregnant woman is inappropriate and exposes mother and fetus to unnecessary hazard. The manufacturer also states that use of indapamide (short course) during pregnancy may be considered to manage edema due to pathologic causes unresponsive to increased recumbency, if such edema causes extreme discomfort.
There are no data on the presence of indapamide in human milk. The manufacturer states that if the use of indapamide is essential to the mother, breast-feeding should be discontinued.
The manufacturer makes no specific dosage recommendations in geriatric patients; in general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, and/or cardiac function and of concomitant disease and drug therapy.
The manufacturer states that clinical studies of indapamide did not include a sufficient number of patients 65 years of age or older to determine whether such patients respond differently than younger individuals but that other reported clinical experience has not identified differences in response between geriatric and younger patients. Severe cases of hyponatremia accompanied by hypokalemia, primarily occurring in elderly females, have been reported with recommended doses of indapamide.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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