Probenecid (probenecid)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Probenecid, a sulfonamide derivative, is a uricosuric agent and inhibitor of tubular secretion of weak organic acids (e.g., penicillins and certain other beta-lactam antibacterials).
USES: This medication is used to prevent gout and gouty arthritis. It will not treat a sudden/severe attack of gout and may make it worse. Probenecid belongs to a class of drugs known as uricosurics.
It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. When uric acid levels get too high, crystals can form in the joints, causing gout. Lowering uric acid levels may also help your kidneys.
Probenecid may be prescribed in combination with certain antibiotics (such as penicillins). It increases the levels of antibiotic in the blood, which helps the antibiotic work better. Probenecid should not be used by children younger than 2 years.
Generic name: probenecid
Pronunciation: (proe-BEN-e-sid)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Probenecid
Indications
The following indications are listed for Probenecid:
- Adjunct Treatment To Inhibit Renal Drug Excretion
- Prevention Of Acute Gout Attack
Also known as: Acute Gout Attack Prophylaxis, Prevention Of Acute Gout Flare.
Dosing
When probenecid is used for the treatment of hyperuricemia associated with gout and gouty arthritis in patients with renal impairment, increased dosage of the drug may be required. The manufacturer states that probenecid may not be effective in patients with chronic renal insufficiency, especially if the glomerular filtration rate is 30 mL/minute or less. It has been suggested that the drug should be avoided in patients with moderate to severe renal impairment (creatinine clearance of less than 50 mL/minute).
Probenecid is administered orally.
Adverse GI effects may be minimized by taking the drug with food or antacids; dosage reduction may be required.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Probenecid crosses the placenta and has been detected in cord blood. The risks and benefits of probenecid should be evaluated when considering use of the drug in women of childbearing potential.
Probenecid is expected to be distributed into human milk; possible effects on nursing infants are not known. The drug should be used with caution in breast-feeding women because of potential risks to nursing infants.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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