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Oxymorphone (oxymorphone HCl)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Oxymorphone hydrochloride is a semisynthetic phenanthrene-derivative opiate agonist.

Oxymorphone hydrochloride is a strong analgesic used in the relief of moderate to severe pain. The drug is also used parenterally as a supplement to anesthesia and for analgesia during labor. Oxymorphone is used in patients with pulmonary edema for its cardiovascular effects and to allay anxiety.

The drug should not be used in the treatment of pulmonary edema resulting from a chemical respiratory irritant.

Generic name: oxymorphone HCl
Pronunciation: (OX-i-MOR-fone)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Oxymorphone:

  • Severe Chronic Pain Requiring Long-Term Opioid Treatment

Dosing

Oxymorphone hydrochloride should be given at the lowest effective dosage and for the shortest duration of therapy consistent with the treatment goals of the patient. Reduced dosage is indicated in poor-risk patients and in geriatric patients. If concomitant therapy with other CNS depressants is required, the lowest effective dosages and shortest possible duration of concomitant therapy should be used.

The manufacturer recommends that initial dosages of 33-50% of the usual dosage be employed when therapy with oxymorphone hydrochloride is initiated in patients receiving other CNS depressants.

For acute pain not related to trauma or surgery, the prescribed quantity should be limited to the amount needed for the expected duration of pain severe enough to require opiate analgesia (generally 3 days or less and rarely more than 7 days). When opiate analgesics are used for the management of chronic noncancer pain, the US Centers for Disease Control and Prevention (CDC) recommends that primary care clinicians carefully reassess individual benefits and risks before prescribing dosages equivalent to 50 mg or more of morphine sulfate daily (approximately 17 mg or more of oxymorphone hydrochloride daily) and avoid dosages equivalent to 90 mg or more of morphine sulfate daily (approximately 30 mg or more of oxymorphone hydrochloride daily) or carefully justify their decision to titrate the dosage to such levels. Other experts recommend consulting a pain management specialist before exceeding a dosage equivalent to 80-120 mg of morphine sulfate daily. For further information on the management of opiate analgesic therapy, see Dosage and Administration: Dosage, in the Opiate Agonists General Statement 28:08.08.

Drug interactions

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Contraindications

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Adverse reactions

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Precautions

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ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data