Protamine Sulfate (protamine sulfate)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Protamine sulfate, which is prepared from the sperm or mature testes of salmon or related species and is composed of arginine, proline, serine, and valine, acts as a heparin antagonist.
Generic name: protamine sulfate
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Protamine Sulfate
Indications
The following indications are listed for Protamine Sulfate:
- Heparin Toxicity
Also known as: Acute Heparin Overdosage.
Dosing
No dosing information is available for this tab.
Protamine sulfate is administered by very slow IV injection. The drug has also been administered by continuous IV infusion+. Protamine sulfate injection is intended for administration without further dilution at a concentration of 10 mg of protamine sulfate per mL. However, if further dilution is desired, 5% dextrose or 0.9% sodium chloride injection may be used. Diluted solutions of protamine sulfate should not be stored since they contain no preservative.
Protamine sulfate usually is administered by very slow IV injection over 10 minutes. No more than 50 mg of the drug should be administered in any 10-minute period. (See Cautions: Precautions and Contraindications.)
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
Animal reproduction studies have not been performed with protamine sulfate. It is not known whether protamine sulfate can cause fetal harm when administered to pregnant women or can affect reproduction capacity. The drug should be used during pregnancy only when clearly needed.
Since it is not known whether protamine sulfate is distributed into human milk, the drug should be used with caution in nursing women.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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