Epioxa (riboflavin 5-phosphate sodium (B2))
Agents for Corneal Collagen Cross-Linking Ophthalmic (Eye) Kit
Last reviewed · Source: First Databank (FDB) drug data
Overview
Riboflavin is a water-soluble, B complex vitamin.
Generic name: riboflavin 5-phosphate sodium (B2)
Drug class: Agents for Corneal Collagen Cross-Linking
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Epioxa
Indications
The following indications are listed for Epioxa:
- Corneal Ectasia Following Refractive Surgery
- Progressive Keratoconus
Also known as: Corneal Ectasia Due To Laser In Situ Keratomileusis, Ectatic Cornea Due To Laser In Situ Keratomileusis, Ectatic Cornea Following Refractive Surgery, Unstable Keratoconus.
Dosing
No dosing information is available for this tab.
Riboflavin is usually administered orally. The drug may also be given by IM injection or IV infusion as a component of multivitamin injections. A parenteral formulation containing riboflavin alone is not currently commercially available.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
The rate and extent of absorption of riboflavin are reportedly affected by propantheline bromide. Prior administration of propantheline bromide delayed the rate of absorption of riboflavin but increased the total amount absorbed, presumably by increasing the residence time of riboflavin at GI absorption sites.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
- Aphakia
- Herpes simplex keratitis
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
More Frequent
- Corneal epithelial degeneration
- Corneal opacity
- Punctate keratitis
Less Frequent
- Vitreous detachment
Rare or Very Rare
- Corneal ulcer
More Frequent
- Blurred vision
- Eye tearing
- Foreign body sensation of eye
- Ocular pain
- Photophobia
- Reduced visual acuity
Less Frequent
- Conjunctival hyperemia
- Corneal dystrophy
- Corneal edema
- Dry eye
- Headache disorder
- Vision impairment
- Visual halos
Rare or Very Rare
- Descemet's membrane fold
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Corneal ectasia following refractive surgery | ||
| H18.71 | ICD10CM | Corneal ectasia |
| H18.711 | ICD10CM | Corneal ectasia, right eye |
| H18.712 | ICD10CM | Corneal ectasia, left eye |
| H18.713 | ICD10CM | Corneal ectasia, bilateral |
| H18.719 | ICD10CM | Corneal ectasia, unspecified eye |
| Progressive keratoconus | ||
| H18.62 | ICD10CM | Keratoconus, unstable |
| H18.621 | ICD10CM | Keratoconus, unstable, right eye |
| H18.622 | ICD10CM | Keratoconus, unstable, left eye |
| H18.623 | ICD10CM | Keratoconus, unstable, bilateral |
| H18.629 | ICD10CM | Keratoconus, unstable, unspecified eye |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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