Deferoxamine (deferoxamine mesylate)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Deferoxamine is a heavy metal antagonist that chelates iron and aluminum.
USES: This medication is used along with other treatments (such as causing vomiting with syrup of ipecac, stomach pumping) to treat sudden iron poisoning. It is most effective when given as soon as possible after the iron was eaten. This medication can also be used to help get rid of iron in patients with high iron levels due to many blood transfusions.
Deferoxamine is an iron-binding agent that belongs to a class of drugs known as heavy metal antagonists. It works by helping the kidneys and gallbladder get rid of the extra iron. This medication is not recommended for use in children less than 3 years old (see also Precautions section).
Generic name: deferoxamine mesylate
Pronunciation: (deff-er-OX-uh-meen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Deferoxamine
Indications
The following indications are listed for Deferoxamine:
- Chronic Iron Overload Due To Repeated Blood Transfusions
- Iron Toxicity
Also known as: Acute Iron Poisoning, Secondary Iron Overload From Multiple Blood Transfusions, Transfusion Hemosiderosis, Transfusion-Induced Iron Overload, Transfusional Hemosiderosis, Transfusional Iron Overload.
Dosing
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Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
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There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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In teratogenicity studies, deferoxamine mesylate appeared to cause delayed ossification and skeletal anomalies in 2 animal species at dosages up to 4.5 times the maximum dosage recommended for humans. For this reason, the drug should not be administered to pregnant women (especially during early pregnancy) or women who may become pregnant unless the potential benefits outweigh the possible risks to the fetus.
It is not known whether deferoxamine is distributed into milk. Because many drugs are distributed into milk, caution should be exercised when deferoxamine is used in nursing women.
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ICD codes
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Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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