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Hemofil M (antihemophilic factor, human)

Antihemophilic Products Intravenous Vial (EA)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Antihemophilic factor (human) is a preparation of antihemophilic factor (blood coagulation factor VIII) prepared from pooled human plasma. Antihemophilic factor/von Willebrand factor complex (human) is a preparation of antihemophilic factor and von Willebrand factor prepared from pooled human plasma.

USES: This medication is used to control and prevent bleeding episodes in people with low levels of factor VIII (hemophilia A). It is also used in these patients before surgery to prevent bleeding. People with low factor VIII levels are at risk for bleeding longer after an injury/surgery and for bleeding inside the body (especially into the joints and muscles).

This product contains human factor VIII, also called antihemophilic factor. This product is used to temporarily replace the missing factor VIII, a protein (clotting factor) that is normally in the blood, so that the blood can clot and the bleeding can stop.

Generic name: antihemophilic factor, human
Pronunciation: (AN-tye-HEE-moe-FIL-ik-FAK-tor)
Drug class: Antihemophilic Products
Therapeutic class: Hematological Agents

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Hemofil M:

  • Bleeding Episode In Hemophilia A
  • Bleeding Prevention In Hereditary Factor Viii Deficiency
  • Hemophilia A

Also known as: Bleeding Prevention In Classic Hemophilia, Bleeding Prevention In Congenital Factor Viii Deficiency, Bleeding Prevention In Hemophilia A, Bleeding Prophylaxis In Hemophilia A, Congenital Factor Viii Deficiency Disease, Hemorrhage Prophylaxis In Hemophilia A, Hemorrhaging In Hemophilia A, Prevention Of Bleeding Episode In Hemophilia A.

Dosing

Dosage of antihemophilic factor (human) and antihemophilic factor/von Willebrand factor complex (human) is expressed in terms of international units (IU, units); 1 unit of antihemophilic factor is approximately equivalent to the amount of factor VIII in 1 mL of fresh pooled human plasma. In general, administration of 1 unit/kg of these antihemophilic factor preparations will increase the circulating factor VIII level by approximately 2 units/dL (2%).

Drug interactions

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Contraindications

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Adverse reactions

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Precautions

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ICD codes

CodeTypeDescription
Bleeding episode in hemophilia A
D66ICD10CMHereditary factor VIII deficiency
Z14.02ICD10CMSymptomatic hemophilia A carrier
Bleeding prevention in hereditary factor VIII deficiency
D66ICD10CMHereditary factor VIII deficiency
Hemophilia A
D66ICD10CMHereditary factor VIII deficiency
Z14.02ICD10CMSymptomatic hemophilia A carrier

ICD code information from First Databank (FDB).

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data