Kepivance (palifermin)
Treatment Induced Mucositis Agents Intravenous Vial (EA)
Last reviewed · Source: First Databank (FDB) drug data
Overview
USES: Palifermin is used by people with blood or bone marrow cancer (such as leukemia, multiple myeloma) who are receiving chemotherapy or radiation along with stem cell transplant. The chemotherapy or radiation can cause severe sores in the mouth and throat (mucositis). Palifermin is used to decrease the risk of these sores and to decrease the time it takes for these sores to heal.
Palifermin may work by increasing the growth of cells in the mouth and throat. This medication should only be used by patients with blood or bone marrow cancer, and not by patients with other types of cancer.
Generic name: palifermin
Pronunciation: (PAL-ee-FER-min)
Drug class: Treatment Induced Mucositis Agents
Therapeutic class: Gastrointestinal Therapy Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Kepivance
Indications
The following indications are listed for Kepivance:
- Prevention Of Chemotherapy-Induced Mucositis
- Prevention Of Radiation Therapy-Induced Mucositis
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Kepivance 5.16 Mg Vial | Maintenance | Inject 60 mcg/kg by intravenous route once daily for 3 days. |
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
- Lactation
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
More Frequent
- Edema
- Erythema
- Fever
- Skin rash
Less Frequent
- Dysesthesia
- Hypoesthesia
- Infection
Rare or Very Rare
- Cataracts
- Increased rate of carcinoma tumor cell growth
- Palmar-plantar erythrodysesthesia
More Frequent
- Elevated serum amylase
- Elevated serum lipase
- Hypertrophic thickening of tongue
- Mouth discoloration
- Pruritus of skin
- Tongue discoloration
Less Frequent
- Arthralgia
- Dysgeusia
- Pain
- Paresthesia
Rare or Very Rare
- Erythema of vagina
- Swelling of vagina
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Prevention of radiation therapy-induced mucositis | ||
| K12.33 | ICD10CM | Oral mucositis (ulcerative) due to radiation |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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