IXEMPRA (ixabepilone)
ANTINEOPLASTIC-EPOTHILONES AND ANALOGS · METASTATIC BREAST CARCINOMA ·+1
R-PHARM US
Drug class
Antineoplastic-Epothilones and Analogs
Antineoplastic epothilones and analogs are a class of non-taxane microtubule-stabilizing cytotoxic agents derived naturally from the myxobacterium *Sorangium cellulosum* or produced semisynthetically. Read more about Antineoplastic-Epothilones and Analogs
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Antineoplastic epothilones and analogs are a class of non-taxane microtubule-stabilizing cytotoxic agents derived naturally from the myxobacterium *Sorangium cellulosum* or produced semisynthetically.
They exert their antineoplastic effect by binding directly to beta-tubulin subunits, promoting microtubule polymerization and inhibiting dynamic depolymerization.
This blocks mitotic spindle function, arresting cancer cells in the G2-M phase and triggering apoptotic cell death.
Clinically represented by agents such as ixabepilone, this drug class is primarily used—either as monotherapy or in combination regimens—to treat locally advanced or metastatic breast cancer that has proven resistant or refractory to standard prior therapies, including anthracyclines and taxanes.
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wikipedia.org
Antineoplastic epothilones and analogs are a class of non-taxane microtubule-stabilizing cytotoxic agents derived naturally from the myxobacterium *Sorangium cellulosum* or produced semisynthetically
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mdpi.com
Antineoplastic epothilones and analogs are a class of non-taxane microtubule-stabilizing cytotoxic agents derived naturally from the myxobacterium *Sorangium cellulosum* or produced semisynthetically They exert their antineoplastic effect by binding directly to beta-tubulin subunits, promoting microtubule polymerization and inhibiting dynamic depolymerization
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researchgate.net
Antineoplastic epothilones and analogs are a class of non-taxane microtubule-stabilizing cytotoxic agents derived naturally from the myxobacterium *Sorangium cellulosum* or produced semisynthetically Clinically represented by agents such as ixabepilone, this drug class is primarily used—either as monotherapy or in combination regimens—to treat locally advanced or metastatic breast cancer that has proven resistant or refractory to standard prior therapies, including anthracyclines and taxanes
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drugbank.com
They exert their antineoplastic effect by binding directly to beta-tubulin subunits, promoting microtubule polymerization and inhibiting dynamic depolymerization
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nih.gov
This blocks mitotic spindle function, arresting cancer cells in the G2-M phase and triggering apoptotic cell death
-
patsnap.com
This blocks mitotic spindle function, arresting cancer cells in the G2-M phase and triggering apoptotic cell death
-
nih.gov
Clinically represented by agents such as ixabepilone, this drug class is primarily used—either as monotherapy or in combination regimens—to treat locally advanced or metastatic breast cancer that has proven resistant or refractory to standard prior therapies, including anthracyclines and taxanes
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