Drug class

Antiretroviral - Capsid Inhibitors

Antiretroviral capsid inhibitors are a distinct therapeutic drug class designed to treat human immunodeficiency virus type 1 (HIV-1) infection. Read more about Antiretroviral - Capsid Inhibitors

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About Antiretroviral - Capsid Inhibitors.

Antiretroviral capsid inhibitors are a distinct therapeutic drug class designed to treat human immunodeficiency virus type 1 (HIV-1) infection.

These agents directly bind to the viral capsid protein, selectively disrupting multiple essential stages of the viral replication cycle, including nuclear import of viral genetic material, core disassembly, and mature capsid core formation.

Clinically, capsid inhibitors—exemplified by lenacapavir—are primarily utilized in combination with an optimized background regimen for heavily treatment-experienced adults with multidrug-resistant HIV-1 infection who have limited remaining treatment options due to resistance, intolerance, or virologic failure.