ASPARLAS (calaspargase pegol-mknl)
ASPARAGINASE ENZYME THERAPY AGENTS · ACUTE LYMPHOID LEUKEMIA
SERVIER PHARMAC
Drug class
Asparaginase Enzyme Therapy Agents
Asparaginase enzyme therapy agents are a specialized class of antineoplastic biologics, frequently classified in compendia and formulary systems under antineoplastic enzyme therapies. Read more about Asparaginase Enzyme Therapy Agents
3 drugs in this class 2 manufacturers
Drugs in Asparaginase Enzyme Therapy Agents
ONCASPAR (pegaspargase)
ASPARAGINASE ENZYME THERAPY AGENTS · ACUTE LYMPHOID LEUKEMIA
SERVIER PHARMAC
RYLAZE (asparaginase Erwinia chrysanthemi (recombinant)-rywn)
ASPARAGINASE ENZYME THERAPY AGENTS · ACUTE LYMPHOID LEUKEMIA ·+1
JAZZ PHARMACEUT
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Asparaginase enzyme therapy agents are a specialized class of antineoplastic biologics, frequently classified in compendia and formulary systems under antineoplastic enzyme therapies.
These therapeutic enzymes—including native, recombinant, and pegylated formulations derived from bacterial sources such as *Escherichia coli* or *Erwinia chrysanthemi*—catalyze the systemic deamination of the nonessential amino acid L-asparagine into aspartic acid and ammonia.
Because certain malignant lymphoblasts lack sufficient asparagine synthetase activity, they depend on extracellular supplies; this profound enzymatic depletion selectively halts leukemic protein synthesis and induces apoptotic cell death.
Clinically, these agents serve as fundamental components of multi-agent chemotherapy regimens primarily indicated for the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma.
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iehp.org
Asparaginase enzyme therapy agents are a specialized class of antineoplastic biologics, frequently classified in compendia and formulary systems under antineoplastic enzyme therapies These therapeutic enzymes—including native, recombinant, and pegylated formulations derived from bacterial sources such as *Escherichia coli* or *Erwinia chrysanthemi*—catalyze the systemic deamination of the nonessential amino acid L-asparagine into aspartic acid and ammonia
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berkeley.edu
Asparaginase enzyme therapy agents are a specialized class of antineoplastic biologics, frequently classified in compendia and formulary systems under antineoplastic enzyme therapies
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fda.gov
These therapeutic enzymes—including native, recombinant, and pegylated formulations derived from bacterial sources such as *Escherichia coli* or *Erwinia chrysanthemi*—catalyze the systemic deamination of the nonessential amino acid L-asparagine into aspartic acid and ammonia Because certain malignant lymphoblasts lack sufficient asparagine synthetase activity, they depend on extracellular supplies; this profound enzymatic depletion selectively halts leukemic protein synthesis and induces apopto...
-
fda.gov
These therapeutic enzymes—including native, recombinant, and pegylated formulations derived from bacterial sources such as *Escherichia coli* or *Erwinia chrysanthemi*—catalyze the systemic deamination of the nonessential amino acid L-asparagine into aspartic acid and ammonia
-
fda.gov
These therapeutic enzymes—including native, recombinant, and pegylated formulations derived from bacterial sources such as *Escherichia coli* or *Erwinia chrysanthemi*—catalyze the systemic deamination of the nonessential amino acid L-asparagine into aspartic acid and ammonia Because certain malignant lymphoblasts lack sufficient asparagine synthetase activity, they depend on extracellular supplies; this profound enzymatic depletion selectively halts leukemic protein synthesis and induces apopto...
-
fda.gov
Clinically, these agents serve as fundamental components of multi-agent chemotherapy regimens primarily indicated for the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma
-
nih.gov
Clinically, these agents serve as fundamental components of multi-agent chemotherapy regimens primarily indicated for the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma
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