FETROJA (cefiderocol sulfate tosylate)
BETA-LACTAMS · NOSOCOMIAL BACTERIAL PNEUMONIA ·+7
SHIONOGI PHARMA
Drug class
Cephalosporin Antibiotics - Siderophore
Siderophore cephalosporins are a specialized class of beta-lactam antibacterial agents engineered with an iron-chelating siderophore side chain. Read more about Cephalosporin Antibiotics - Siderophore
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Drugs in Cephalosporin Antibiotics - Siderophore
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Siderophore cephalosporins are a specialized class of beta-lactam antibacterial agents engineered with an iron-chelating siderophore side chain.
They function via a "Trojan horse" mechanism, binding extracellular ferric iron to exploit bacterial active iron transport systems for rapid penetration through the outer membrane of Gram-negative bacilli into the periplasmic space, where they inhibit penicillin-binding proteins and halt peptidoglycan cell wall synthesis.
Possessing enhanced stability against hydrolysis by diverse beta-lactamases and carbapenemases, agents in this class are primarily utilized for severe, multidrug-resistant Gram-negative bacterial infections.
Major therapeutic indications include complicated urinary tract infections, pyelonephritis, hospital-acquired bacterial pneumonia, and ventilator-associated bacterial pneumonia.
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umn.edu
Siderophore cephalosporins are a specialized class of beta-lactam antibacterial agents engineered with an iron-chelating siderophore side chain
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drugs.com
Siderophore cephalosporins are a specialized class of beta-lactam antibacterial agents engineered with an iron-chelating siderophore side chain Possessing enhanced stability against hydrolysis by diverse beta-lactamases and carbapenemases, agents in this class are primarily utilized for severe, multidrug-resistant Gram-negative bacterial infections
-
nih.gov
They function via a "Trojan horse" mechanism, binding extracellular ferric iron to exploit bacterial active iron transport systems for rapid penetration through the outer membrane of Gram-negative bacilli into the periplasmic space, where they inhibit penicillin-binding proteins and halt peptidoglycan cell wall synthesis
-
nih.gov
They function via a "Trojan horse" mechanism, binding extracellular ferric iron to exploit bacterial active iron transport systems for rapid penetration through the outer membrane of Gram-negative bacilli into the periplasmic space, where they inhibit penicillin-binding proteins and halt peptidoglycan cell wall synthesis
-
nih.gov
Possessing enhanced stability against hydrolysis by diverse beta-lactamases and carbapenemases, agents in this class are primarily utilized for severe, multidrug-resistant Gram-negative bacterial infections
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fda.gov
Major therapeutic indications include complicated urinary tract infections, pyelonephritis, hospital-acquired bacterial pneumonia, and ventilator-associated bacterial pneumonia
-
fda.gov
Major therapeutic indications include complicated urinary tract infections, pyelonephritis, hospital-acquired bacterial pneumonia, and ventilator-associated bacterial pneumonia
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