Corticotropins

Corticotropins are a class of anterior pituitary peptide hormone agents comprising natural adrenocorticotropic hormone (ACTH) and its synthetic analogs, such as repository corticotropin and cosyntropin Therapeutically, they bind to melanocortin receptors to stimulate the adrenal cortex to synthesize and release endogenous corticosteroids, while also exerting direct receptor-mediated immunomodulatory actions In clinical practice, corticotropin formulations are primarily indicated to induce endoge...

Corticotropins are a class of anterior pituitary peptide hormone agents comprising natural adrenocorticotropic hormone (ACTH) and its synthetic analogs, such as repository corticotropin and cosyntropin In clinical practice, corticotropin formulations are primarily indicated to induce endogenous steroidogenesis for diagnostic evaluation of adrenocortical insufficiency, as monotherapy for infantile spasms, and as adjunctive treatment for acute exacerbations of multiple sclerosis, rheumatic disease...

Therapeutically, they bind to melanocortin receptors to stimulate the adrenal cortex to synthesize and release endogenous corticosteroids, while also exerting direct receptor-mediated immunomodulatory actions

Therapeutically, they bind to melanocortin receptors to stimulate the adrenal cortex to synthesize and release endogenous corticosteroids, while also exerting direct receptor-mediated immunomodulatory actions

In clinical practice, corticotropin formulations are primarily indicated to induce endogenous steroidogenesis for diagnostic evaluation of adrenocortical insufficiency, as monotherapy for infantile spasms, and as adjunctive treatment for acute exacerbations of multiple sclerosis, rheumatic diseases, and nephrotic syndrome