KALYDECO (ivacaftor)
CYSTIC FIBROSIS TRANSMEMB. CONDUCT. REG. (CFTR) POTENTIATORS · CYSTIC FIBROSIS WITH RESPONSIVE CFTR MUTATION
VERTEX PHARMACEUTICAL
Drug class
Cystic Fibrosis Transmemb. Conduct. Reg. (CFTR) Potentiators
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are a targeted class of small-molecule CFTR modulators developed to improve defective chloride and bicarbonate transport across epithelial membranes. Read more about Cystic Fibrosis Transmemb. Conduct. Reg. (CFTR) Potentiators
6 drugs in this class 1 manufacturers
Drugs in Cystic Fibrosis Transmemb. Conduct. Reg. (CFTR) Potentiators
ORKAMBI (lumacaftor/ivacaftor)
CYSTIC FIBROSIS TRANSMEMB. CONDUCT. REG. (CFTR) POTENTIATORS · CYSTIC FIBROSIS WITH HOMOZYGOUS F508DEL MUTATION IN CFTR GENE
VERTEX PHARMACEUTICAL
SYMDEKO (tezacaftor/ivacaftor)
CYSTIC FIBROSIS TRANSMEMB. CONDUCT. REG. (CFTR) POTENTIATORS · CYSTIC FIBROSIS WITH HOMOZYGOUS F508DEL MUTATION IN CFTR GENE ·+1
VERTEX PHARMACEUTICAL
ORKAMBI (lumacaftor/ivacaftor)
CYSTIC FIBROSIS TRANSMEMB. CONDUCT. REG. (CFTR) POTENTIATORS · CYSTIC FIBROSIS WITH HOMOZYGOUS F508DEL MUTATION IN CFTR GENE
VERTEX PHARMACEUTICAL
TRIKAFTA (elexacaftor/tezacaftor/ivacaftor)
CYSTIC FIBROSIS TRANSMEMB. CONDUCT. REG. (CFTR) POTENTIATORS · CYSTIC FIBROSIS WITH HOMOZYGOUS F508DEL MUTATION IN CFTR GENE ·+1
VERTEX PHARMACEUTICAL
ALYFTREK (vanzacaftor calcium/tezacaftor/deutivacaftor)
CYSTIC FIBROSIS TRANSMEMB. CONDUCT. REG. (CFTR) POTENTIATORS · CYSTIC FIBROSIS WITH HOMOZYGOUS F508DEL MUTATION IN CFTR GENE ·+2
VERTEX PHARMACEUTICAL
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Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are a targeted class of small-molecule CFTR modulators developed to improve defective chloride and bicarbonate transport across epithelial membranes.
They act directly on CFTR ion channels localized at the cell surface by increasing their open-channel probability, thereby facilitating ion conductance and mucosal hydration.
This therapeutic class is primarily indicated for the treatment of cystic fibrosis in patients harboring responsive CFTR gene mutations—notably gating defects or residual function variants—either as monotherapy or combined with CFTR correctors to restore channel function.
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cff.org
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are a targeted class of small-molecule CFTR modulators developed to improve defective chloride and bicarbonate transport across epithelial membranes They act directly on CFTR ion channels localized at the cell surface by increasing their open-channel probability, thereby facilitating ion conductance and mucosal hydration
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nih.gov
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are a targeted class of small-molecule CFTR modulators developed to improve defective chloride and bicarbonate transport across epithelial membranes They act directly on CFTR ion channels localized at the cell surface by increasing their open-channel probability, thereby facilitating ion conductance and mucosal hydration
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nv.gov
They act directly on CFTR ion channels localized at the cell surface by increasing their open-channel probability, thereby facilitating ion conductance and mucosal hydration
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eocco.com
This therapeutic class is primarily indicated for the treatment of cystic fibrosis in patients harboring responsive CFTR gene mutations—notably gating defects or residual function variants—either as monotherapy or combined with CFTR correctors to restore channel function
-
nih.gov
This therapeutic class is primarily indicated for the treatment of cystic fibrosis in patients harboring responsive CFTR gene mutations—notably gating defects or residual function variants—either as monotherapy or combined with CFTR correctors to restore channel function
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