Drug class

Factor VII

Rather than an independent therapeutic drug class, "Factor VII" refers to a specific endogenous vitamin K–dependent clotting factor, typically administered as exogenous activated factor VII (factor VIIa) within the broader class of hemostatic agents and coagulation factors. Read more about Factor VII

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Drugs in Factor VII

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About Factor VII.

Rather than an independent therapeutic drug class, "Factor VII" refers to a specific endogenous vitamin K–dependent clotting factor, typically administered as exogenous activated factor VII (factor VIIa) within the broader class of hemostatic agents and coagulation factors.

It promotes hemostasis by complexing with exposed tissue factor and directly activating factor X and factor IX on platelet surfaces, thereby generating a burst of thrombin that facilitates fibrin clot formation independently of factor VIII or factor IX.

Therapeutically, recombinant factor VIIa formulations serve as bypassing agents to manage and prevent bleeding episodes or surgical hemorrhage in patients with congenital hemophilia A or B with inhibitors, acquired hemophilia, congenital factor VII deficiency, and Glanzmann thrombasthenia.