Drug class

Fluorouracil and Related Rescue Agents

"Fluorouracil and Related Rescue Agents" is an administrative and formulary classification rather than a standard pharmacological drug class, primarily designating emergency antidotes used to counter fluorouracil or capecitabine overexposure. Read more about Fluorouracil and Related Rescue Agents

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About Fluorouracil and Related Rescue Agents.

"Fluorouracil and Related Rescue Agents" is an administrative and formulary classification rather than a standard pharmacological drug class, primarily designating emergency antidotes used to counter fluorouracil or capecitabine overexposure.

Represented clinically by uridine triacetate, these agents function by competing with toxic fluoropyrimidine metabolites for incorporation into cellular RNA and metabolic pathways, thereby arresting ongoing cellular injury.

Their therapeutic role is limited to the emergency treatment of adult and pediatric patients experiencing fluoropyrimidine overdose or early-onset, life-threatening toxicities—such as severe cardiac, central nervous system, or gastrointestinal complications—during treatment for various solid tumors, notably colorectal, breast, gastric, and pancreatic cancers.