KORLYM (mifepristone)
ABORTIFACIENTS · TYPE 2 DIABETES ADJUNCT IN CUSHING'S SYNDROME
CORCEPT THERAPE
Drug class
Glucocorticoid Receptor Antagonists
Glucocorticoid receptor antagonists are a therapeutic class of agents that bind directly to intracellular glucocorticoid receptors, competitively inhibiting cortisol and other glucocorticoids from mediating gene transcription and downstream signaling pathways. Read more about Glucocorticoid Receptor Antagonists
4 drugs in this class 2 manufacturers
Drugs in Glucocorticoid Receptor Antagonists
MIFEPRISTONE
ABORTIFACIENTS · TYPE 2 DIABETES ADJUNCT IN CUSHING'S SYNDROME
CORCEPT THERAPE
MIFEPRISTONE
ABORTIFACIENTS · TYPE 2 DIABETES ADJUNCT IN CUSHING'S SYNDROME
TEVA USA
LIFYORLI (relacorilant)
GLUCOCORTICOID RECEPTOR ANTAGONISTS · MALIGNANT NEOPLASM OF FALLOPIAN TUBE ·+2
CORCEPT THERAPE
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Glucocorticoid receptor antagonists are a therapeutic class of agents that bind directly to intracellular glucocorticoid receptors, competitively inhibiting cortisol and other glucocorticoids from mediating gene transcription and downstream signaling pathways.
By blocking glucocorticoid receptor activation at the tissue level, these drugs counteract the pathological effects of excessive endogenous glucocorticoid signaling without necessarily reducing systemic hormone production.
Clinically, this class is primarily utilized to control hyperglycemia and other manifestations of hypercortisolemia in patients with endogenous Cushing syndrome.
Beyond endocrinology, glucocorticoid receptor antagonists are also investigated in oncology to reverse glucocorticoid-mediated resistance to chemotherapy and targeted therapies, as well as in select psychiatric and metabolic conditions.
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patsnap.com
Glucocorticoid receptor antagonists are a therapeutic class of agents that bind directly to intracellular glucocorticoid receptors, competitively inhibiting cortisol and other glucocorticoids from mediating gene transcription and downstream signaling pathways
-
nih.gov
Glucocorticoid receptor antagonists are a therapeutic class of agents that bind directly to intracellular glucocorticoid receptors, competitively inhibiting cortisol and other glucocorticoids from mediating gene transcription and downstream signaling pathways
-
nih.gov
By blocking glucocorticoid receptor activation at the tissue level, these drugs counteract the pathological effects of excessive endogenous glucocorticoid signaling without necessarily reducing systemic hormone production Clinically, this class is primarily utilized to control hyperglycemia and other manifestations of hypercortisolemia in patients with endogenous Cushing syndrome
-
cancer.gov
By blocking glucocorticoid receptor activation at the tissue level, these drugs counteract the pathological effects of excessive endogenous glucocorticoid signaling without necessarily reducing systemic hormone production
-
nih.gov
Beyond endocrinology, glucocorticoid receptor antagonists are also investigated in oncology to reverse glucocorticoid-mediated resistance to chemotherapy and targeted therapies, as well as in select psychiatric and metabolic conditions
-
aacrjournals.org
Beyond endocrinology, glucocorticoid receptor antagonists are also investigated in oncology to reverse glucocorticoid-mediated resistance to chemotherapy and targeted therapies, as well as in select psychiatric and metabolic conditions
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