Drug class

Hepatitis C - NS5A Replication Complex Inhibitors

Hepatitis C nonstructural protein 5A (NS5A) replication complex inhibitors are a class of direct-acting antiviral medications. Read more about Hepatitis C - NS5A Replication Complex Inhibitors

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About Hepatitis C - NS5A Replication Complex Inhibitors.

Hepatitis C nonstructural protein 5A (NS5A) replication complex inhibitors are a class of direct-acting antiviral medications.

They target and bind to the viral NS5A protein, a multifunctional phosphoprotein that is essential for the assembly and function of the hepatitis C virus replication complex.

By disrupting NS5A, these agents block both viral RNA genome replication and virion assembly.

They are indicated for the treatment of chronic hepatitis C virus infection across multiple genotypes, administered as standalone agents or, more commonly, within fixed-dose combination direct-acting antiviral regimens to achieve sustained virologic response.