Drug class

Influenza Antiviral Agents - PA Endonuclease Inhibitor

Influenza antiviral agents in the polymerase acidic (PA) endonuclease inhibitor class are targeted antiviral medications designed to impede influenza A and B viral replication. Read more about Influenza Antiviral Agents - PA Endonuclease Inhibitor

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About Influenza Antiviral Agents - PA Endonuclease Inhibitor.

Influenza antiviral agents in the polymerase acidic (PA) endonuclease inhibitor class are targeted antiviral medications designed to impede influenza A and B viral replication.

They function by inhibiting the endonuclease activity of the viral RNA polymerase PA subunit, thereby blocking the "cap-snatching" process essential for viral messenger RNA transcription.

Clinically, this drug class—exemplified by baloxavir marboxil—is indicated for the treatment of acute, uncomplicated influenza in patients who have been symptomatic for no more than 48 hours, as well as for post-exposure prophylaxis following contact with an infected individual.