Protein C Replacement

Protein C replacement refers to a therapeutic class of plasma-derived physiological anticoagulant concentrates designed to restore circulating levels of functional protein C.

Upon intravenous administration, the proenzyme is activated in vivo by the thrombin-thrombomodulin complex into activated protein C, which complexes with protein S to proteolytically inactivate coagulation factors Va and VIIIa, thereby curbing excessive thrombin generation and downregulating clot formation.

Clinically, these agents are primarily indicated for neonatal, pediatric, and adult patients with severe congenital protein C deficiency to treat and prevent life-threatening thrombotic complications, most notably purpura fulminans and recurrent venous thromboembolism.