Drug class

Psoralens, Systemic

Systemic psoralens are orally administered furocoumarin photosensitizers used in photochemotherapy regimens alongside controlled ultraviolet A radiation, commonly known as PUVA therapy. Read more about Psoralens, Systemic

3 drugs in this class 2 manufacturers

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Drugs in Psoralens, Systemic

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METHOXSALEN

ANTIPSORIATICS · SEVERE RECALCITRANT PSORIASIS
STRIDES PHARMA
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About Psoralens, Systemic.

Systemic psoralens are orally administered furocoumarin photosensitizers used in photochemotherapy regimens alongside controlled ultraviolet A radiation, commonly known as PUVA therapy.

Following systemic absorption and distribution to the skin, these compounds intercalate into cellular DNA; subsequent UVA exposure activates them to form interstrand cross-links and monoadducts with pyrimidine bases, thereby inhibiting DNA synthesis, suppressing rapid cellular proliferation, and exerting localized immunomodulatory effects.

Systemic psoralens, represented predominantly by methoxsalen, are indicated for the management of severe, recalcitrant psoriasis, extensive vitiligo, and cutaneous T-cell lymphoma, such as mycosis fungoides.