Drug class

Rho(D) Immune Globulins

Rho(D) immune globulins are a specialized class of plasma-derived hyperimmune globulins containing high titers of antibodies directed against the Rh(D) antigen on red blood cells. Read more about Rho(D) Immune Globulins

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About Rho(D) Immune Globulins.

Rho(D) immune globulins are a specialized class of plasma-derived hyperimmune globulins containing high titers of antibodies directed against the Rh(D) antigen on red blood cells.

They function primarily through antibody-mediated immune suppression by binding to circulating Rh(D)-positive red blood cells and clearing them from maternal circulation before maternal active immunization can occur.

Clinically, these agents are primarily indicated in Rh-negative individuals to prevent Rh isoimmunization and hemolytic disease of the fetus and newborn following obstetric delivery, complications, procedures, or incompatible transfusions.

In addition, specific intravenous formulations are utilized in Rh-positive individuals to elevate platelet counts in immune thrombocytopenia by competitively saturating splenic Fc receptors and reducing platelet clearance.