Drug class

Topical Antineoplastic Retinoids

Topical antineoplastic retinoids are a specialized formulary subclass of locally applied vitamin A derivatives and rexinoids used to treat cutaneous malignancies. Read more about Topical Antineoplastic Retinoids

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Drugs in Topical Antineoplastic Retinoids

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About Topical Antineoplastic Retinoids.

Topical antineoplastic retinoids are a specialized formulary subclass of locally applied vitamin A derivatives and rexinoids used to treat cutaneous malignancies.

These agents, primarily including topical bexarotene and alitretinoin, bind intracellular retinoic acid receptors (RAR) and retinoid X receptors (RXR) to modulate gene expression, inducing cellular differentiation, inhibiting malignant proliferation, and promoting apoptosis.

Their primary therapeutic role is in managing skin lesions associated with early-stage or refractory cutaneous T-cell lymphoma, such as mycosis fungoides, as well as cutaneous manifestations of AIDS-related Kaposi sarcoma.