Drug class

Topical Enzymes

Topical enzymes are a functional class of dermatological medications formulated with exogenous proteolytic enzymes, such as collagenase or bromelain-derived proteinases, applied directly to cutaneous lesions. Read more about Topical Enzymes

3 drugs in this class 2 manufacturers

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Drugs in Topical Enzymes

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About Topical Enzymes.

Topical enzymes are a functional class of dermatological medications formulated with exogenous proteolytic enzymes, such as collagenase or bromelain-derived proteinases, applied directly to cutaneous lesions.

Their principal mechanism involves selective enzymatic debridement, breaking down collagen and necrotic tissue substrates anchoring devitalized debris to the wound bed while largely sparing healthy, viable tissue.

Clinically, these agents are primarily indicated in wound care and burn management to facilitate healing, promote granulation, and debride chronic dermal ulcers—including pressure ulcers, diabetic foot ulcers, and venous stasis ulcers—as well as severe thermal burns.