Dibenzyline (phenoxybenzamine HCl)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Phenoxybenzamine hydrochloride is a haloalkylamine alpha-adrenergic blocking agent.
USES: This medication is used to treat high blood pressure and heavy sweating due to a certain adrenal gland tumor (pheochromocytoma). Phenoxybenzamine belongs to a class of drugs known as alpha blockers. It works by relaxing blood vessels so that blood can flow more easily.
Generic name: phenoxybenzamine HCl
Pronunciation: (fen-OX-ee-BEN-za-meen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Dibenzyline
Indications
The following indications are listed for Dibenzyline:
- Pheochromocytoma Adjunct Therapy
Also known as: Adjunct Medication Therapy For Pheochromocytoma.
Dosing
No dosing information is available for this tab.
Phenoxybenzamine hydrochloride is administered orally. GI irritation may be reduced by giving the drug with milk or in divided doses.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
The effects of alpha-adrenergic stimulating sympathomimetic agents are antagonized by phenoxybenzamine. Drugs that stimulate both alpha- and beta-adrenergic receptors (e.g., epinephrine) cause vasodilation, an increased hypotensive response, and tachycardia in patients receiving phenoxybenzamine.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Animal reproduction studies have not been performed with phenoxybenzamine, and it is not known whether the drug can cause fetal harm when administered to pregnant women. The drug has been used in a limited number of women during the third trimester of pregnancy in the treatment of hypertension caused by pheochromocytoma without apparent harm to the woman or fetus. Phenoxybenzamine should be used during pregnancy only when clearly needed.
It is not known whether phenoxybenzamine is distributed in human milk. Because of the potential for serious adverse reactions to phenoxybenzamine in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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