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Mononine (factor IX)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Factor IX (human) is a preparation of blood coagulation factor IX prepared from pooled human plasma. Factor IX complex (human), also known as a 3-factor prothrombin complex concentrate (PCC), is a preparation of nonactivated blood coagulation factors II, VII, IX, and X derived from pooled human plasma.

USES: This medication is used to prevent or control bleeding in people with little or no factor IX (due to hemophilia B, Christmas disease). Factor IX is a protein (clotting factor) in the blood that works with other clotting factors to help the blood clot and stop bleeding. People with little or no factor IX are at risk for bleeding longer after an injury/surgery or bleeding suddenly (often in the joints/muscle) without an obvious cause.

This medication should not be used to reverse the effects of "blood thinners" (such as warfarin). Most types of this medication should not be used to treat other types of factor deficiencies (such as factors II, VII, VIII, X) or factor problems (such as inhibitor to factor XIII). If you are using this medication for one of these conditions, consult your doctor or pharmacist to make sure that you are using the right product.

Generic name: factor IX
Pronunciation: (FACK-ter nine)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

Today’s intelligence on Mononine

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Indications

The following indications are listed for Mononine:

  • Hemophilia B

Also known as: Christmas Disease, Factor Ix Deficiency, Factor Ix Dysfunction, Plasma Thromboplastin Component Deficiency, Ptc Deficiency.

Dosing

Dose (potency) of factor IX (human) and factor IX complex (human) is expressed in terms of international units (IU, units) of factor IX activity. One unit is approximately equivalent to the amount of factor IX activity in 1 mL of pooled normal human plasma. The dosage of factor IX (human) or factor IX complex (human) required to establish hemostasis in patients with hemophilia B will vary with each patient and circumstance since there is considerable variability among patients and their clinical conditions. Therefore, dosage should be carefully individualized and factor IX levels monitored frequently during therapy with the drugs. Close monitoring of factor IX levels is particularly important in cases of severe hemorrhage or major surgery. The dosing frequency for maintaining sufficiently increased levels of a deficient factor also is variable; although minor bleeding episodes may be controlled with a single dose, more severe bleeding may require administration of additional doses.

Drug interactions

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Contraindications

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Adverse reactions

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Precautions

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ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data