Oralair (grass pollen-orchard/sweet vernal/rye/Kentucky/timothy, std.)
Allergenic Extract-Grass Pollens Sublingual Tablet, Sublingual
Last reviewed · Source: First Databank (FDB) drug data
Overview
USES: This medication is used to treat certain allergies that may occur seasonally or year round. It is an extract of certain plant pollens that can cause allergies. Before prescribing this medication, your doctor must do lab/medical tests (such as skin or IgE tests) to learn what you are allergic to.
This pollen allergen extract works by making your body less sensitive to the pollens (such as ragweed, grasses) that cause your allergies. This medication will not work right away to relieve allergy symptoms. When taken as directed, it may help relieve symptoms such as sneezing, runny/stuffy nose, cough, or itchy/watery eyes that are caused by allergies.
Generic name: grass pollen-orchard/sweet vernal/rye/Kentucky/timothy, std.
Pronunciation: (POL-uh-n)
Drug class: Allergenic Extract-Grass Pollens
Therapeutic class: Biologicals
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Oralair
Indications
The following indications are listed for Oralair:
- Allergic Rhinitis Due To Grass Pollen
Also known as: Seasonal Grass Pollinosis.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Oralair 300 Ir Sublingual Tab | Maintenance | Place 1 tablet under the tongue and allow to dissolve by sublingual route once daily. |
| Oralair 300 Ir Starter Pack | Maintenance | Place 1 tablet under the tongue and allow to dissolve by sublingual route once daily. |
| Oralair 300 Ir Adult Sample Kt | Maintenance | Place 1 tablet under the tongue and allow to dissolve by sublingual route once daily. |
No dosing information is available for this tab.
Drug interactions
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There are no contraindication interactions for this drug.
Severe Interaction: Action is required to reduce the risk of severe adverse interaction.
Allergen Immunotherapy/Beta-Blockers
SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction.
MECHANISM OF ACTION: Beta-blockers may mask early signs and symptoms of anaphylaxis, make the treatment of anaphylaxis more difficult, and increase the severity of the reaction.
CLINICAL EFFECTS: Beta-blockers may reduce a patient's ability to survive a systemic allergic reaction to allergen immunotherapy. Signs and symptoms of anaphylaxis may be masked.
PREDISPOSING FACTORS: Concurrent use of epinephrine with beta-blockers may result in hypertension with reflex bradycardia. Epinephrine resistance in patients with anaphylaxis has been reported.
PATIENT MANAGEMENT: Avoid concomitant administration of immunotherapy and beta-blockers if possible. If patients cannot safely discontinue beta-blockers but have a history of moderate to severe sting-induced anaphylaxis, venom immunotherapy is indicated because the risk of anaphylaxis related to a venom sting is greater than the risk of an immunotherapy-related systemic reaction. In patients taking beta-blockers for whom an acceptable alternative is not available, withholding allergen immunotherapy may be the best option. If both drugs are administered, monitor closely for signs and symptoms of anaphylaxis. Use caution when treating anaphylaxis with epinephrine since response may be poor. Epinephrine administration may worsen anaphylaxis because beta-blockers block the beta effects of epinephrine, which results in predomination of alpha effects. The plasma clearance of epinephrine is decreased. Glucagon may help in the treatment of refractory anaphylaxis in patients receiving beta-blockers.
DISCUSSION: In a case report, a patient taking propranolol was administered pollen extract immunotherapy and immediately developed anaphylaxis. Treatment with epinephrine did not improve symptoms and patient was subsequently intubated.(2) In another case report, a patient taking propranolol was given pollen immunotherapy and developed anaphylaxis. Difficulty in maintaining an adequate blood pressure and pulse continued for several hours despite epinephrine and other supportive measures.(3) There are other case reports of patients taking propranolol with venom immunotherapy that were refractory to treatment.(6-7)
Moderate Interaction: Assess the risk to the patient and take action as needed.
Allergen Immunotherapy/Ustekinumab
SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.
MECHANISM OF ACTION: Ustekinumab may decrease the protective effect of allergen immunotherapy.
CLINICAL EFFECTS: Ustekinumab may increase the risk of an allergic reaction to allergen immunotherapy.
PREDISPOSING FACTORS: None determined.
PATIENT MANAGEMENT: Exercise caution in patients receiving or who have received allergen immunotherapy. Counsel patients on the possible increased risk of an allergic reaction.(1)
DISCUSSION: Concurrent use of ustekinumab and allergen immunotherapy has not been evaluated.(1)
Contraindications
There is no enhanced messaging for this drug.
- Eosinophilic esophagitis
- Severe persistent asthma
- 30 day risk period post-myocardial infarction
- Invasive dental procedure
- Life-threatening cardiac arrhythmias
- Oral lichen planus
- Stomatitis
- Unstable angina pectoris
- Severe uncontrolled hypertension
Adverse reactions
There is no enhanced messaging for this drug.
Less Frequent
- Tongue swelling
Rare or Very Rare
- Altered consciousness
- Anaphylaxis
- Angioedema
- Asthma exacerbation
- Eosinophilia
- Eosinophilic esophagitis
- Exacerbation of ulcerative colitis
- Hashimoto thyroiditis
- Hypotension
- Laryngismus
- Oral lichen planus
- Throat constriction
More Frequent
- Cough
- Ear itching
- Edema of the oral soft tissue
- Mouth irritation
- Oral pruritus
- Pharyngitis
- Pruritis of tongue
- Sore throat
Less Frequent
- Dysphagia
Rare or Very Rare
- Acute abdominal pain
- Cheilitis
- Chest discomfort
- Diarrhea
- Dizziness
- Drowsy
- Dysarthria
- Dyspepsia
- Earache
- Erythema
- Facial edema
- Flu-like symptoms
- Gastritis
- Hoarseness
- Hyperventilation
- Lymphadenopathy
- Oral hypoesthesia
- Palpitations
- Parotitis
- Periorbital edema
- Pneumonia
- Sialoadenitis
- Sialorrhea
- Stomatitis
- Stridor
- Tachycardia
- Tinnitus
- Tremor
- Urticaria
- Vomiting
- Wheezing
- Xerostomia
Precautions
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No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Allergic rhinitis due to grass pollen | ||
| J30.1 | ICD10CM | Allergic rhinitis due to pollen |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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