Dyazide (triamterene/hydrochlorothiazide)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Triamterene is a potassium-sparing diuretic.
Hydrochlorothiazide is a thiazide diuretic and antihypertensive agent.
USES: This medication is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen. This drug is also used to treat high blood pressure.
Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains 2 medications, triamterene and hydrochlorothiazide. They are both "water pills" (diuretics) that cause you to make more urine.
This helps your body get rid of extra water and salt. Triamterene also helps treat or prevent low blood potassium levels.
Generic name: triamterene/hydrochlorothiazide
Pronunciation: (HYE-droe-KLOR-oh-THYE-a-zide/try-AM-ter-een)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Dyazide
Indications
The following indications are listed for Dyazide:
- Edema
- Hypertension
Also known as: Edematous Sodium Retaining Conditions, Elevated Blood Pressure, Essential Hypertension, Hyperpiesia, Hyperpiesis, Hypertensive Disorder, Systemic Arterial Hypertension.
Dosing
Dosage of triamterene should be individualized according to the patient's requirements and response. It has been theorized that abrupt withdrawal of triamterene may result in rebound kaliuresis; therefore, the drug should be withdrawn gradually. Experts state that diuretics should be administered at a dosage sufficient to achieve optimal volume status and relieve congestion without inducing an excessively rapid reduction in intravascular volume, which could result in hypotension, renal dysfunction, or both.
Dosage of hydrochlorothiazide should be individualized according to the patient's requirements and response. The lowest dosage necessary to produce the desired clinical effect should be used. If hydrochlorothiazide is added to the regimen of a patient stabilized on a potent hypotensive agent, dosage of the hypotensive agent should initially be reduced to avoid the possibility of severe hypotension.
Triamterene is administered orally. Triamterene has been administered IV+, but the poor solubility of the drug and acidity of the solutions make administration by this route extremely difficult and a parenteral dosage form currently is not available in the US.
Hydrochlorothiazide is administered orally.
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Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
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There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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There are no adequate and well-controlled studies using triamterene in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risks (these include adverse effects reported in adults) to the fetus.
Since triamterene has been shown to distribute into milk in animals and may distribute into human milk, the drug should not be used in nursing women. If use of triamterene is deemed essential, nursing should be discontinued.
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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